Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Catherine J. Drummond"'
Autor:
Madeline B. Searcy, Randolph K. Larsen, Bradley T. Stevens, Yang Zhang, Hongjian Jin, Catherine J. Drummond, Casey G. Langdon, Katherine E. Gadek, Kyna Vuong, Kristin B. Reed, Matthew R. Garcia, Beisi Xu, Darden W. Kimbrough, Grace E. Adkins, Nadhir Djekidel, Shaina N. Porter, Patrick A. Schreiner, Shondra M. Pruett-Miller, Brian J. Abraham, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) driven by the expression of the PAX3-FOXO1 (P3F) fusion oncoprotein is an aggressive subtype of pediatric rhabdomyosarcoma. FP-RMS histologically resembles developing muscle yet occurs throughout the
Externí odkaz:
https://doaj.org/article/af11c11b372b412d83edd57dfaac71cf
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c0c030dc1c54c61a794787a99cca008
Autor:
Casey G. Langdon, Katherine E. Gadek, Matthew R. Garcia, Myron K. Evans, Kristin B. Reed, Madeline Bush, Jason A. Hanna, Catherine J. Drummond, Matthew C. Maguire, Patrick J. Leavey, David Finkelstein, Hongjian Jin, Patrick A. Schreiner, Jerold E. Rehg, Mark E. Hatley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axi
Externí odkaz:
https://doaj.org/article/0413e8410b0248ed86492edc2f4f4634
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53 in cells. We
Externí odkaz:
https://doaj.org/article/c70bab1df6ec4076bb2c93aa455abeeb
Publikováno v:
Molecules, Vol 26, Iss 3, p 552 (2021)
Amsacrine, an anticancer drug first synthesised in 1970 by Professor Cain and colleagues, showed excellent preclinical activity and underwent clinical trial in 1978 under the auspices of the US National Cancer Institute, showing activity against acut
Externí odkaz:
https://doaj.org/article/3a345b1c41cb4573a9b93c642f5f8b07
Autor:
Catherine J. Drummond, Mark E. Hatley
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following reprogramm
Externí odkaz:
https://doaj.org/article/aa43b7ae2e3d481d95f1a2657fa850e6
Autor:
Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C. A. D’Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M. Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C. Earnshaw, Anna R. McCarthy, Nicholas J. Westwood, Marie Arsenian-Henriksson, David P. Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The original PDF version of this Article listed the authors as “Marcus J.G.W. Ladds,” where it should have read “Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond et al.#”. Also in the PDF version, it was incorrectly st
Externí odkaz:
https://doaj.org/article/6b88c0d66cd64b709fb079a6627015c7
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 41K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568593bb00a1a2261ad018ca602ae0ea
https://doi.org/10.1158/1535-7163.22498024
https://doi.org/10.1158/1535-7163.22498024
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 38K, Inhibition of purified SirT1 and SirT2 by tenovin-D3 using FdL substrates at 15 μM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc93a105baf8bf79fea430b1f4321ec
https://doi.org/10.1158/1535-7163.22498048.v1
https://doi.org/10.1158/1535-7163.22498048.v1
Autor:
Sonia Laín, Nicholas J. Westwood, Marcus J.G.W. Ladds, Lisa Pirrie, Ingeborg M.M. van Leeuwen, Catherine J. Drummond, Johanna Campbell, Maureen Higgins, Marijke C.C. Sachweh, Anna R. McCarthy
PDF file - 178K, Tenovin-D3 causes cell cycle arrest in SirT2 wild type but not knockout cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c66a53bc3efea8b2882ea7dd2e4b2f
https://doi.org/10.1158/1535-7163.22498039
https://doi.org/10.1158/1535-7163.22498039