Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Catherine J Whittaker"'
Autor:
Kathryn A Ryan, Gillian S Slack, Anthony C Marriott, Jennifer A Kane, Catherine J Whittaker, Nigel J Silman, Miles W Carroll, Karen E Gooch
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202675 (2018)
Seasonal influenza virus infections cause yearly epidemics which are the source of a significant public health burden worldwide. The ferret model for human influenza A virus (IAV) is widely used and has several advantages over other animal models suc
Externí odkaz:
https://doaj.org/article/5e55374e2631474e9aa403c22a5cd93f
Autor:
Anthony C Marriott, Mike Dennis, Jennifer A Kane, Karen E Gooch, Graham Hatch, Sally Sharpe, Claudia Prevosto, Gail Leeming, Elsa-Gayle Zekeng, Karl J Staples, Graham Hall, Kathryn A Ryan, Simon Bate, Nathifa Moyo, Catherine J Whittaker, Bassam Hallis, Nigel J Silman, Ajit Lalvani, Tom M Wilkinson, Julian A Hiscox, James P Stewart, Miles W Carroll
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157887 (2016)
Non-human primates are the animals closest to humans for use in influenza A virus challenge studies, in terms of their phylogenetic relatedness, physiology and immune systems. Previous studies have shown that cynomolgus macaques (Macaca fascicularis)
Externí odkaz:
https://doaj.org/article/ce0f136ad41145778e5c088d27afe3a2
Autor:
Anthony C Marriott, Brian K Dove, Catherine J Whittaker, Christine Bruce, Kathryn A Ryan, Thomas J Bean, Emma Rayner, Geoff Pearson, Irene Taylor, Stuart Dowall, Jenna Plank, Edmund Newman, Wendy S Barclay, Nigel J Dimmock, Andrew J Easton, Bassam Hallis, Nigel J Silman, Miles W Carroll
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94090 (2014)
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interven
Externí odkaz:
https://doaj.org/article/b91968a775054d9da5b3ae35471ec157
Autor:
Anthony C. Marriott, Karen E. Gooch, Phillip J. Brown, Kathryn A. Ryan, Nicola J. Jones, Natasha Merredew, Nathan Wiblin, Oliver Dibben, Helen Bright, Bassam Hallis, Catherine J. Whittaker, Miles W. Carroll
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Live attenuated influenza vaccine (LAIV) is widely used to protect humans from seasonal influenza infection, particularly in children. In contrast to inactivated vaccines, the LAIV can induce both mucosal and cellular immune responses. Here
Externí odkaz:
https://doaj.org/article/f9f97dcbeef94e3ca43053085c7250dd
Autor:
Jemma Paterson, Kathryn A. Ryan, Daniel Morley, Nicola J. Jones, Paul Yeates, Yper Hall, Catherine J. Whittaker, Francisco J. Salguero, Anthony C. Marriott
Publikováno v:
Pathogens, Vol 12, Iss 5, p 668 (2023)
Animal models of influenza are important in preclinical research for the study of influenza infection and the assessment of vaccines, drugs and therapeutics. Here, we show that Golden Syrian hamsters (Mesocricetus auratus) inoculated via the intranas
Externí odkaz:
https://doaj.org/article/768b52275713427da4dcd8754bf979cd
Autor:
Kathryn A. Ryan, Kevin R. Bewley, Susan A. Fotheringham, Gillian S. Slack, Phillip Brown, Yper Hall, Nadina I. Wand, Anthony C. Marriott, Breeze E. Cavell, Julia A. Tree, Lauren Allen, Marilyn J. Aram, Thomas J. Bean, Emily Brunt, Karen R. Buttigieg, Daniel P. Carter, Rebecca Cobb, Naomi S. Coombes, Steve J. Findlay-Wilson, Kerry J. Godwin, Karen E. Gooch, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas H. Hender, Holly E. Humphries, Laura Hunter, Catherine M. K. Ho, Chelsea L. Kennard, Stephanie Leung, Stephanie Longet, Didier Ngabo, Karen L. Osman, Jemma Paterson, Elizabeth J. Penn, Steven T. Pullan, Emma Rayner, Oliver Skinner, Kimberley Steeds, Irene Taylor, Tom Tipton, Stephen Thomas, Carrie Turner, Robert J. Watson, Nathan R. Wiblin, Sue Charlton, Bassam Hallis, Julian A. Hiscox, Simon Funnell, Mike J. Dennis, Catherine J. Whittaker, Michael G. Catton, Julian Druce, Francisco J. Salguero, Miles W. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
SARS-CoV-2 induces mild infection in ferret model. Here, Ryan et al. characterise optimal infection dosage inducing upper respiratory tract (UTR) viral shedding, progression time of viral shedding, and pathology in ferrets and finally provide evidenc
Externí odkaz:
https://doaj.org/article/a8afc90cbc2f4422be7dc5bc8923c3cf
Autor:
Kathryn A Ryan, Katarzyna E Schewe, Jonathan Crowe, Susan A Fotheringham, Yper Hall, Richard Humphreys, Anthony C Marriott, Jemma Paterson, Emma Rayner, Francisco J Salguero, Robert J Watson, Catherine J Whittaker, Miles W Carroll, Oliver Dibben
Publikováno v:
The Journal of Infectious Diseases. 225:404-412
Cocirculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in coinfected patients. The ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce29ba68b8706c4b49fad8ae732d41b5
https://doi.org/10.1093/infdis/jiab594
https://doi.org/10.1093/infdis/jiab594
Autor:
Miles W. Carroll, Karen E. Gooch, Catherine J. Whittaker, Gillian S. Slack, Paul Yeates, Anthony C. Marriott, Kathryn A. Ryan, Ross Fothergill, Phillip Brown
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
An effective universal vaccine for influenza will likely need to induce virus-specific T-cells, which are the major mediator of heterosubtypic cross-protection between different subtypes of influenza A virus. In this study we characterise the cell-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5febb64a626ccc9c39b06bba4176babe
http://link.springer.com/article/10.1038/s41598-019-38885-0
http://link.springer.com/article/10.1038/s41598-019-38885-0
Autor:
Kathryn A. Ryan, Jonathan Crowe, Katarzyna E Schewe, Robert J. Watson, Richard Humphreys, Catherine J. Whittaker, Jemma Paterson, Miles W. Carroll, Francisco J. Salguero, Yper Hall, Oliver Dibben, Emma Rayner, Anthony C. Marriott, Susan A. Fotheringham
Co-circulation of SARS-CoV-2 and influenza viruses could pose unpredictable risks to health systems globally, with recent studies suggesting more severe disease outcomes in co-infected patients. The lack of a readily available COVID-19 vaccine has re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95f5a8522d5d2a219d4fecf29f94301a
https://doi.org/10.1101/2021.02.01.429110
https://doi.org/10.1101/2021.02.01.429110
Autor:
Sue Charlton, Julian Druce, Bassam Hallis, Robert J. Watson, Tom Tipton, Julia A. Tree, Naomi Coombes, Thomas Hender, Simon G. P. Funnell, Elizabeth J Penn, Emily Brunt, Gillian S. Slack, Kimberley Steeds, Stephanie Longet, Chelsea L Kennard, Stephanie Leung, Daniel P. Carter, Rebecca Cobb, Marilyn Aram, Breeze E. Cavell, Thomas Bean, Nathan R Wiblin, Laura Hunter, Karen L. Osman, Francisco J. Salguero, Anthony C. Marriott, Karen R. Buttigieg, Miles W. Carroll, Kevin R. Bewley, Holly E. Humphries, Kathryn A. Ryan, Phillip Brown, Kerry J Godwin, Michael G Catton, Emma Rayner, Carrie Turner, Julian A. Hiscox, Steve J. Findlay-Wilson, Nadina Wand, Yper Hall, Didier Ngabo, Rachel Halkerston, Susan A. Fotheringham, Jade Gouriet, Catherine J. Whittaker, Stephen Thomas, Irene Taylor, Mike Dennis, Karen E. Gooch, Oliver Skinner, Catherine M K Ho, Jemma Paterson, Steven T. Pullan, Lauren Allen, Debbie J Harris
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report a dose titration study of SARS-CoV-2 in the ferret model. After a high (5 × 106 pfu) and medium (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff5e41ea44447f0a4f60a9873c2353d
http://europepmc.org/articles/PMC7782478
http://europepmc.org/articles/PMC7782478