BIITE: A Tool to Determine HLA Class II Epitopes from T Cell ELISpot Data.

Autor: Lies Boelen, Patrick K O'Neill, Kathryn J Quigley, Catherine J Reynolds, Bernard Maillere, John H Robinson, Ganjana Lertmemongkolchai, Daniel M Altmann, Rosemary J Boyton, Becca Asquith

Publikováno v: PLoS Computational Biology, Vol 12, Iss 3, p e1004796 (2016)

Activation of CD4+ T cells requires the recognition of peptides that are presented by HLA class II molecules and can be assessed experimentally using the ELISpot assay. However, even given an individual's HLA class II genotype, identifying which clas

Externí odkaz: https://doaj.org/article/bf41c06d42fd4022a66f3f8a1f57a94c

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

Autor: Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Áine McKnight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, COVIDsortium investigators, Rosemary J. Boyton

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Long Covid is a consequence of eit

Externí odkaz: https://doaj.org/article/a677c6017bb84e09bc50cdbc69054faa

COVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Autor: Dragana Milojkovic, Catherine J. Reynolds, Diana Mūnoz Sandoval, Franziska P. Pieper, Siyi Liu, Corinna Pade, Joseph M. Gibbons, Áine McKnight, Sandra Loaiza, Renuka Palanicawander, Andrew J. Innes, Simone Claudiani, Jane F. Apperley, Daniel M. Altmann, Rosemary J. Boyton

Publikováno v: Leukemia. 37:244-247

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d697162925a219d408e1793cddbc7927
https://doi.org/10.1038/s41375-022-01787-8

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes

Autor: Arnone Nithichanon, Darawan Rinchai, Surachat Buddhisa, Pornpun Saenmuang, Chidchamai Kewcharoenwong, Bianca Kessler, Prasong Khaenam, Ploenchan Chetchotisakd, Bernard Maillere, John Robinson, Catherine J. Reynolds, Rosemary J. Boyton, Daniel M. Altmann, Ganjana Lertmemongkolchai

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Burkholderia pseudomallei (Bp) is an environmental bacterial pathogen that causes potentially lethal sepsis in susceptible individuals and is considered a Category B, Tier-1 biothreat agent. As such, it is crucial to gain an improved understanding of

Externí odkaz: https://doaj.org/article/a3d0787df49748db8785d59378efca84

Immune boosting by B.1.1.529

Autor: Catherine J, Reynolds, Corinna, Pade, Joseph M, Gibbons, Ashley D, Otter, Kai-Min, Lin, Diana, Muñoz Sandoval, Franziska P, Pieper, David K, Butler, Siyi, Liu, George, Joy, Nasim, Forooghi, Thomas A, Treibel, Charlotte, Manisty, James C, Moon, Amanda, Semper, Tim, Brooks, Áine, McKnight, Daniel M, Altmann, Rosemary J, Boyton, Hakam, Abbass, Aderonke, Abiodun, Mashael, Alfarih, Zoe, Alldis, Oliver E, Amin, Mervyn, Andiapen, Jessica, Artico, João B, Augusto, Georgina L, Baca, Sasha N L, Bailey, Anish N, Bhuva, Alex, Boulter, Ruth, Bowles, Olivia V, Bracken, Ben, O'Brien, Natalie, Bullock, Gabriella, Captur, Olivia, Carr, Nicola, Champion, Carmen, Chan, Aneesh, Chandran, Tom, Coleman, Jorge, Couto de Sousa, Xose, Couto-Parada, Eleanor, Cross, Teresa, Cutino-Moguel, Silvia, D'Arcangelo, Rhodri H, Davies, Brooke, Douglas, Cecilia, Di Genova, Keenan, Dieobi-Anene, Mariana O, Diniz, Anaya, Ellis, Karen, Feehan, Malcolm, Finlay, Marianna, Fontana, Sasha, Francis, David, Gillespie, Derek, Gilroy, Matt, Hamblin, Gabrielle, Harker, Georgia, Hemingway, Jacqueline, Hewson, Wendy, Heywood, Lauren M, Hickling, Bethany, Hicks, Aroon D, Hingorani, Lee, Howes, Ivie, Itua, Victor, Jardim, Wing-Yiu Jason, Lee, Melaniepetra, Jensen, Jessica, Jones, Meleri, Jones, Vikas, Kapil, Caoimhe, Kelly, Hibba, Kurdi, Jonathan, Lambourne, Aaron, Lloyd, Sarah, Louth, Mala K, Maini, Vineela, Mandadapu, Katia, Menacho, Celina, Mfuko, Kevin, Mills, Sebastian, Millward, Oliver, Mitchelmore, Christopher, Moon, James, Moon, Sam M, Murray, Mahdad, Noursadeghi, Ashley, Otter, Susana, Palma, Ruth, Parker, Kush, Patel, Mihaela, Pawarova, Steffen E, Petersen, Brian, Piniera, Lisa, Rannigan, Alicja, Rapala, Amy, Richards, Matthew, Robathan, Joshua, Rosenheim, Cathy, Rowe, Matthew, Royds, Jane, Sackville West, Genine, Sambile, Nathalie M, Schmidt, Hannah, Selman, Andreas, Seraphim, Mihaela, Simion, Angelique, Smit, Michelle, Sugimoto, Leo, Swadling, Stephen, Taylor, Nigel, Temperton, Stephen, Thomas, George D, Thornton, Art, Tucker, Ann, Varghese, Jessry, Veerapen, Mohit, Vijayakumar, Tim, Warner, Sophie, Welch, Hannah, White, Theresa, Wodehouse, Lucinda, Wynne, Dan, Zahedi, Benjamin, Chain

Publikováno v: Science (New York, N.Y.). 377(6603)

The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e47a2d7e1518955cbeb0d526fe6ff6db
https://pubmed.ncbi.nlm.nih.gov/35699621