Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Catherine J Mummery"'
Autor:
Catherine J Mummery, Henrik Zetterberg, Rury R Holman, Brian Tom, Ivan Koychev, Peter Hellyer, Amanda I Adler, Elizabeth Coulthard, Benjamin R Underwood, Adam Hampshire, Charles Marshall, Paul Edison, Joanne E Milton, Joe Butchart, Francesca Cormack
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), currently marketed for type 2 diabetes and obesity, may offer novel mechanisms to delay or prevent neurotoxicity associated with Alzheimer’s disease (AD). The impact of semaglutide
Externí odkaz:
https://doaj.org/article/16420298a11d448f9195b369edad8d96
Autor:
Rebecca Louise Bond, Laura E Downey, Philip SJ Weston, Catherine F Slattery, Camilla N Clark, Kirsty eMacpherson, Catherine J Mummery, Jason D Warren
Publikováno v:
Frontiers in Human Neuroscience, Vol 10 (2016)
Despite considerable evidence for abnormalities of self-awareness in Alzheimer’s disease (AD), the cognitive mechanisms of altered self-processing in AD have not been fully defined. Here we addressed this issue in a detailed analysis of self/non-se
Externí odkaz:
https://doaj.org/article/748cc684ed5846d0b5270a76c5455e78
Autor:
Andrew J. Aschenbrenner, Jason Hassenstab, Guoqiao Wang, Yan Li, Chengjie Xiong, Eric McDade, David B. Clifford, Stephen Salloway, Martin Farlow, Roy Yaari, Eden Y. J. Cheng, Karen C. Holdridge, Catherine J. Mummery, Colin L. Masters, Ging-Yuek Hsiung, Ghulam Surti, Gregory S. Day, Sandra Weintraub, Lawrence S. Honig, James E. Galvin, John M. Ringman, William S. Brooks, Nick C. Fox, Peter J. Snyder, Kazushi Suzuki, Hiroyuki Shimada, Susanne Gräber, Randall J. Bateman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Demonstrating a slowing in the rate of cognitive decline is a common outcome measure in clinical trials in Alzheimer’s disease (AD). Selection of cognitive endpoints typically includes modeling candidate outcome measures in the many, richly phenoty
Externí odkaz:
https://doaj.org/article/729c320574be4f4a868a3bad97db96d9
Autor:
Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn, Everard G. B. Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O. Rinne, Albert C. Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E. Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M. Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A. Norris, Rebecca Crean, Danielle L. Graham, Ellen Huang, Elena Ratti, C. Frank Bennett, Candice Junge, Roger M. Lane
Publikováno v:
Nature medicine 29(6), 1437-1447 (2023). doi:10.1038/s41591-023-02326-3
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduc
Autor:
Ross W. Paterson, Catherine F. Slattery, Teresa Poole, Jennifer M. Nicholas, Nadia K. Magdalinou, Jamie Toombs, Miles D. Chapman, Michael P. Lunn, Amanda J. Heslegrave, Martha S Foiani, Philip S. J. Weston, Ashvini Keshavan, Jonathan D. Rohrer, Martin N. Rossor, Jason D. Warren, Catherine J. Mummery, Kaj Blennow, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Le
Externí odkaz:
https://doaj.org/article/cd0b740c050b4d6384bd565c2c72b223
Autor:
Sanjay Budhdeo, Anderson Rodrigues Brandão de Paiva, Charles Wade, Laura Cardia Gomes Lopes, Bruno Della-Ripa, Indran Davagnanam, Leandro Lucato, Catherine J. Mummery, Fernando Kok, Henry Houlden, David J. Werring, David S. Lynch
Publikováno v:
Journal of Neurology. 269:6673-6677
Autor:
Jennifer Murphy, Paul Aisen, Frederik Barkhof, Carmen Castrillo‐Viguera, Wenting Cheng, Sharon Cohen, Oskar Hansson, Ping He, Takeshi Iwatsubo, Judy Jaeger, Philip H. Montenigro, Carrie E. Rubel, Catherine J. Mummery, John O'Gorman, Annie M Racine, Bruno Vellas, Shuang Wu, Samantha Budd Haeberlein
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Charles R. Marshall, Chris J. D. Hardy, Lucy L. Russell, Camilla N. Clark, Katrina M. Dick, Emilie V. Brotherhood, Rebecca L. Bond, Catherine J. Mummery, Jonathan M. Schott, Jonathan D. Rohrer, James M. Kilner, Jason D. Warren
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
BackgroundInteroception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects. Interoceptive impairment may contribute to the profound socioemotional sy
Externí odkaz:
https://doaj.org/article/0572c62e3ad74330ae1ad6d5c5beb970
Autor:
Jason D. Warren, Catherine J. Mummery, Sebastian J. Crutch, Rimona S. Weil, Jeremy C. S. Johnson, Nick C. Fox, Jonathan D. Rohrer, Jonathan M. Schott, Chris J.D. Hardy, Laura McWhirter, Charles R. Marshall, Martin N. Rossor
Publikováno v:
Johnson, J C S, Mcwhirter, L, Hardy, C J D, Crutch, S J, Marshall, C R, Mummery, C J, Rohrer, J D, Rossor, M N, Schott, J M, Weil, R S, Fox, N C & Warren, J D 2021, ' Suspecting dementia: canaries, chameleons and zebras ', Practical Neurology, pp. practneurol-2021-003019 . https://doi.org/10.1136/practneurol-2021-003019
The early and accurate diagnosis of dementia is more important than ever before but remains challenging. Dementia is increasingly the business of neurologists and, with ageing populations worldwide, will become even more so in future. Here we outline
Autor:
Christopher H. van Dyck, Roger Clarnette, Susan Mills, John C. Morris, Carlos Cruchaga, Anna Santacruz, Ging-Yuek Robin Hsiung, Roy Yaari, Suman Jayadev, Caroline Giacobino, William S. Brooks, Robert A. Koeppe, Raquel Sánchez-Valle, Anne M. Fagan, Eric McDade, Sarah B. Berman, Catherine J. Mummery, Florence Pasquier, Scott M. Berry, Randall J. Bateman, Brian A. Gordon, Jorge J. Llibre-Guerra, Maïté Formaglio, Paul S. Aisen, Paulo Fontoura, Mark A. Mintun, Bruno Dubois, Erik D. Roberson, Kelley Coalier, Ronald G. Thomas, Martin R. Farlow, John R. Sims, Serge Gauthier, Douglas Galasko, Mario Masellis, G. Mustafa Surti, Barbara A. Wendelberger, Guoqiao Wang, James J. Lah, Yan Li, David B. Clifford, David Wallon, Paul Delmar, Alison Goate, Rachelle S. Doody, Didier Hannequin, Stephen Salloway, Geoffrey A. Kerchner, Karen C. Holdridge, Ivonne Z. Jimenez-Velazquez, Janice M. Hitchcock, Monika Baudler, Lawrence S. Honig, Tammie L.S. Benzinger, Clifford R. Jack, Peter J. Snyder, Scott W. Andersen, J. Pariente, Andrew J. Aschenbrenner, Jason Hassenstab, Richard J. Perrin, Colin L. Masters, Chengjie Xiong, Jared R. Brosch, B. Joy Snider
Publikováno v:
Nat Med
Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes decades before the onset of clinical symptoms, enabling testing of interventions in the asymptomatic and symptomatic stages to delay or slow disease progression. We