Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine J Hutchings"'
Autor:
Sean M. Peterson, Catherine J. Hutchings, Cameron F. Hu, Melina Mathur, Janelle W. Salameh, Fumiko Axelrod, Aaron K. Sato
Publikováno v:
Expert Opinion on Drug Discovery. 18:417-428
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75116ff73dec24eb1b520190a37f259
https://doi.org/10.1080/17460441.2023.2193389
https://doi.org/10.1080/17460441.2023.2193389
Autor:
Catherine J Hutchings
Publikováno v:
Antibody Therapeutics
Antibodies are now well established as therapeutics with many additional advantages over small molecules and peptides relative to their selectivity, bioavailability, half-life and effector function. Major classes of membrane-associated protein target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44536ac1254cb07dfd961edacae1cc60
https://doi.org/10.1093/abt/tbaa023
https://doi.org/10.1093/abt/tbaa023
Autor:
Catherine J. Hutchings
Publikováno v:
Expert Opinion on Biological Therapy
G protein-coupled receptors (GPCRs) play key roles in many biological functions and are linked to many diseases across all therapeutic areas. As such, GPCRs represent a significant opportunity for antibody-based therapeutics.The structure of the majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51edfc13affe14d533ef1b1abe9c0cec
https://pubmed.ncbi.nlm.nih.gov/32264722
https://pubmed.ncbi.nlm.nih.gov/32264722
Publikováno v:
mAbs
It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdc065f06a74402cef98fed207b8454
https://doi.org/10.1080/19420862.2018.1548232
https://doi.org/10.1080/19420862.2018.1548232
Autor:
Mark Soave, Catherine J Hutchings, Alastair J.H. Brown, G. Cseke, Jeanette Woolard, Stephen J. Hill
Publikováno v:
Biochemical Pharmacology. 147:38-54
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turkey β1-adrenoceptor (β1A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bc62a15aa85509afbb6f2669b7d03c4
https://doi.org/10.1016/j.bcp.2017.10.015
https://doi.org/10.1016/j.bcp.2017.10.015
Publikováno v:
Nature Reviews Drug Discovery. 16:787-810
G-protein-coupled receptors (GPCRs) are activated by a diverse range of ligands, from large proteins and proteases to small peptides, metabolites, neurotransmitters and ions. They are expressed on all cells in the body and have key roles in physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c517858aa42456c2b58af584e5995a
https://doi.org/10.1038/nrd.2017.91
https://doi.org/10.1038/nrd.2017.91
Autor:
Mark, Soave, Gabriella, Cseke, Catherine J, Hutchings, Alastair J H, Brown, Jeanette, Woolard, Stephen J, Hill
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Recent interest has focused on antibodies that can discriminate between different receptor conformations. Here we have characterised the effect of a monoclonal antibody (mAb3), raised against a purified thermo-stabilised turke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63b12cac034dba90fb7f5e28b08c1ed2
https://pubmed.ncbi.nlm.nih.gov/29102678
https://pubmed.ncbi.nlm.nih.gov/29102678
Autor:
Andrei Zhukov, Ali Jazayeri, Malcolm Peter Weir, G. Cseke, Jahnavi Pandya-Pathak, Jeanette Woolard, Fiona H. Marshall, Stephen J. Hill, Markus Koglin, Christopher J. Langmead, Catherine J Hutchings, Greg J. Osborne
Publikováno v:
mAbs. 6:246-261
Thermostabilized G protein-coupled receptors used as antigens for in vivo immunization have resulted in the generation of functional agonistic anti-β1-adrenergic (β1AR) receptor monoclonal antibodies (mAbs). The focus of this study was to examine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a382df213f393a528179b4d1c8af8
https://doi.org/10.4161/mabs.27226
https://doi.org/10.4161/mabs.27226
Publikováno v:
mAbs. 2:594-606
G protein-coupled receptors (GPCRs) are one of the most important classes of targets for small molecule drug discovery, but many current GPCRs of interest are proving intractable to small molecule discovery and may be better approached with bio-thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915efd797dec5f40e84a8bc5d2ba8d8c
https://doi.org/10.4161/mabs.2.6.13420
https://doi.org/10.4161/mabs.2.6.13420
Publikováno v:
Human immunology. 42(4)
HGPSS associates with the TCRBV6S7 locus within the TCR β-chain gene complex. However, Vβ6.7 T cells, encoded by this locus, have never been implicated in the salivary gland destruction that charac-terizes primary Sjogren's syndrome. Both Vβ13 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5269835de0ce420876a61adfca51304
https://pubmed.ncbi.nlm.nih.gov/7558918
https://pubmed.ncbi.nlm.nih.gov/7558918