Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Catherine J, Thiffeault"'
Autor:
Susan D. O'Lone, Maria Engel, Ronald D. Fiedler, Maik Schuler, Kelley E. Sanok, Krista L. Dobo, Catherine J. Thiffeault, Stephanie L. Coffing, Donna A. Dickinson, William C. Gunther, Thomas J. Shutsky
Publikováno v:
Environmental and Molecular Mutagenesis. 55:492-499
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0f71d6e3dccac49af2f77952153c43
https://doi.org/10.1002/em.21863
https://doi.org/10.1002/em.21863
Publikováno v:
Environmental and Molecular Mutagenesis. 55:64-69
Previous studies with TK6 cells have shown that extending the recovery period after pulse treatment allows for greater micronucleus expression for some compounds. This study explores the role of cell cycle delay in micronucleus expression after pulse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3abb6e56ac4e5b2546a4cd064c9b6ccb
https://doi.org/10.1002/em.21810
https://doi.org/10.1002/em.21810
Autor:
Zoryana Cammerer, Maik Schuler, Ronald D. Fiedler, Stephanie L. Coffing, Catherine J. Thiffeault, Krista L. Dobo, Thomas J. Shutsky, William C. Gunther
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 725:13-21
In recent years, experimental evidence has accumulated that supports the existence of sublinear dose–response relationships at low doses of DNA reactive mutagens. However, creating the in vivo data necessary to allow for a more detailed dose–resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d6685417e80cd573216b3ec6f58ab1
https://doi.org/10.1016/j.mrgentox.2011.06.005
https://doi.org/10.1016/j.mrgentox.2011.06.005
Autor:
William C. Gunther, Ann Schuermans, John Nicolette, Fabrice Nesslany, Ronald D. Fiedler, Stephen D. Dertinger, Céline Defrain, Laura Custer, Thomas J. Shutsky, Catherine J. Thiffeault, Robert H. Heflich, Paul Sonders, Amanda Giddings, Ljubica Krsmanovic, Javed A. Bhalli, Eleanor C. Wilde, Anthony M. Lynch, James T. MacGregor, Kevin Sweder, Osamu Tajima, Takafumi Kimoto, Andrew Henwood, Jing Shi, Terry Van Doninck, Souk Phonethepswath, Carol Gleason, Bas-jan M. van der Leede, Hans-Werner Vohr, Daniel J. Roberts, Pamela Weller, Azeddine Elhajouji, Yoshie Hiwata, Leon F. Stankowski, Joel Murray, Julia Kenny, Kentaro Tanaka
Publikováno v:
Environmental and Molecular Mutagenesis. 52:690-698
A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Four
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f313510d8a658754853218a9f4fc7a2
https://doi.org/10.1002/em.20672
https://doi.org/10.1002/em.20672
Autor:
William C, Gunther, Stephanie L, Coffing, Donna A, Dickinson, Maria E, Engel, Ronald D, Fiedler, Susan D, O'Lone, Kelley E, Sanok, Catherine J, Thiffeault, Thomas J, Shutsky, Maik J, Schuler, Krista L, Dobo
Publikováno v:
Environmental and molecular mutagenesis. 55(6)
Ethyl methanesulfonate (EMS) was evaluated as part of the validation effort for the rat Pig-a mutation assay and compared with other well-established in vivo genotoxicity endpoints. Male Sprague-Dawley (SD) rats were given a daily dose of 0, 6.25, 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f283fe0fbef317707abfa4b5e8cf0816
https://pubmed.ncbi.nlm.nih.gov/24599777
https://pubmed.ncbi.nlm.nih.gov/24599777
Autor:
Javed A. Bhalli, Maria Engel, Catherine J. Thiffeault, Ronald D. Fiedler, Mason G. Pearce, Zoryana Cammerer, Thomas J. Shutsky, Stephanie L. Coffing, Vasily N. Dobrovolsky, Xuefei Cao, Robert H. Heflich, William C. Gunther, Joseph G. Shaddock, Maik Schuler, Krista L. Dobo, Donna A. Dickinson
Publikováno v:
Environmental and molecular mutagenesis. 52(9)
N-Ethyl-N-nitrosourea (ENU) was evaluated as part of the Stage III trial for the rat Pig-a gene mutation assay. Groups of six- to eight-week-old male Sprague Dawley (SD) or Fischer 344 (F344) rats were given 28 daily doses of the phosphate buffered s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a99e0ee85a81564a9bc7d29a193ecb
https://pubmed.ncbi.nlm.nih.gov/22167886
https://pubmed.ncbi.nlm.nih.gov/22167886
Autor:
Catherine J. Thiffeault, Stephanie L. Coffing, Maik Schuler, Maria Engel, Donna A. Dickinson, Thomas J. Shutsky, Richard A. Spellman
Publikováno v:
Environmental and molecular mutagenesis. 52(4)
The in vivo bone marrow (BM) micronucleus assay is one of the three tests in the standard test battery to assess the genotoxic potential of a pharmaceutical candidate. In some cases, depending on results of in vitro studies, the route of administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8843f254c15741ca56dc5b3bfd8503c1
https://pubmed.ncbi.nlm.nih.gov/20872852
https://pubmed.ncbi.nlm.nih.gov/20872852
Autor:
Maik Schuler, Nkechi Maduka, Maria Engel, Megan Colman, Ramadevi Gudi, Donna A. Dickinson, Jennifer R. Cheung, Shyam Kumar, Catherine J. Thiffeault, Jocelyn Sherman, Anna Szkudlinska
Publikováno v:
Mutation research. 702(2)
The in vitro micronucleus assay has been extensively used as an in vitro screening tool to identify test articles that might have aneugenic or clastogenic potential. Currently, the Organization for Economic Co-operation and Development (OECD) is work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531c7b2736739b0238e1787771256ce9
https://pubmed.ncbi.nlm.nih.gov/20399283
https://pubmed.ncbi.nlm.nih.gov/20399283