Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

Autor: Daniel M. Altmann, Catherine J. Reynolds, George Joy, Ashley D. Otter, Joseph M. Gibbons, Corinna Pade, Leo Swadling, Mala K. Maini, Tim Brooks, Amanda Semper, Áine McKnight, Mahdad Noursadeghi, Charlotte Manisty, Thomas A. Treibel, James C. Moon, COVIDsortium investigators, Rosemary J. Boyton

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)

Abstract Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Long Covid is a consequence of eit

Externí odkaz: https://doaj.org/article/a677c6017bb84e09bc50cdbc69054faa

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Autor: Ivan Doykov, Tomas Baldwin, Justyna Spiewak, Kimberly C. Gilmour, Joseph M. Gibbons, Corinna Pade, Catherine J. Reynolds, Áine McKnight, Mahdad Noursadeghi, Mala K. Maini, Charlotte Manisty, Thomas Treibel, Gabriella Captur, Marianna Fontana, Rosemary J. Boyton, Daniel M. Altmann, Tim Brooks, Amanda Semper, James C. Moon, Kevin Mills, Wendy E. Heywood, Hakam Abbass, Aderonke Abiodun, Mashael Alfarih, Zoe Alldis, Oliver E. Amin, Mervyn Andiapen, Jessica Artico, João B. Augusto, Georgina L. Baca, Sasha N.L. Bailey, Anish N. Bhuva, Alex Boulter, Ruth Bowles, Olivia V. Bracken, Ben O’Brien, Natalie Bullock, David K. Butler, Olivia Carr, Nicola Champion, Carmen Chan, Aneesh Chandran, Tom Coleman, Jorge Couto de Sousa, Xose Couto-Parada, Eleanor Cross, Teresa Cutino-Moguel, Silvia D’Arcangelo, Rhodri H. Davies, Brooke Douglas, Cecilia Di Genova, Keenan Dieobi-Anene, Mariana O. Diniz, Anaya Ellis, Karen Feehan, Malcolm Finlay, Nasim Forooghi, Sasha Francis, David Gillespie, Derek Gilroy, Matt Hamblin, Gabrielle Harker, Georgia Hemingway, Jacqueline Hewson, Wendy Heywood, Lauren M. Hickling, Bethany Hicks, Aroon D. Hingorani, Lee Howes, Ivie Itua, Victor Jardim, Wing-Yiu Jason Lee, Melaniepetra Jensen, Jessica Jones, Meleri Jones, George Joy, Vikas Kapil, Caoimhe Kelly, Hibba Kurdi, Jonathan Lambourne, Kai-Min Lin, Siyi Liu, Aaron Lloyd, Sarah Louth, Vineela Mandadapu, Katia Menacho, Celina Mfuko, Sebastian Millward, Oliver Mitchelmore, Christopher Moon, James Moon, Diana Muñoz Sandoval, Sam M. Murray, Ashley Otter, Susana Palma, Ruth Parker, Kush Patel, Mihaela Pawarova, Steffen E. Petersen, Brian Piniera, Franziska P. Pieper, Lisa Rannigan, Alicja Rapala, Amy Richards, Matthew Robathan, Joshua Rosenheim, Cathy Rowe, Matthew Royds, Jane Sackville West, Genine Sambile, Nathalie M. Schmidt, Hannah Selman, Andreas Seraphim, Mihaela Simion, Angelique Smit, Michelle Sugimoto, Leo Swadling, Stephen Taylor, Nigel Temperton, Stephen Thomas, George D. Thornton, Thomas A. Treibel, Art Tucker, Ann Varghese, Jessry Veerapen, Mohit Vijayakumar, Tim Warner, Sophie Welch, Hannah White, Theresa Wodehouse, Lucinda Wynne, Dan Zahedi

Publikováno v: Cell Reports: Methods, Vol 2, Iss 9, Pp 100279- (2022)

Summary: Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune

Externí odkaz: https://doaj.org/article/9be530f264774b93a8869c019914391d

BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis

Autor: Julen Tomás-Cortázar, Lorenzo Bossi, Conor Quinn, Catherine J. Reynolds, David K. Butler, Niamh Corcoran, Maitiú Ó Murchú, Eve McMahon, Mahavir Singh, Patpong Rongkard, Juan Anguita, Alfonso Blanco, Susanna J. Dunachie, Daniel Altmann, Rosemary J. Boyton, Johan Arnold, Severine Giltaire, Siobhán McClean

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Melioidosis is a potentially fatal bacterial disease caused by Burkholderia pseudomallei and is estimated to cause 89,000 deaths per year in endemic areas of Southeast Asia and Northern Australia. People with diabetes mellitus are most at risk of mel

Externí odkaz: https://doaj.org/article/38af46c094f745d39e3ae2d0c23f0a1a

COVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Autor: Dragana Milojkovic, Catherine J. Reynolds, Diana Mūnoz Sandoval, Franziska P. Pieper, Siyi Liu, Corinna Pade, Joseph M. Gibbons, Áine McKnight, Sandra Loaiza, Renuka Palanicawander, Andrew J. Innes, Simone Claudiani, Jane F. Apperley, Daniel M. Altmann, Rosemary J. Boyton

Publikováno v: Leukemia. 37:244-247

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d697162925a219d408e1793cddbc7927
https://doi.org/10.1038/s41375-022-01787-8

Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes

Autor: Arnone Nithichanon, Darawan Rinchai, Surachat Buddhisa, Pornpun Saenmuang, Chidchamai Kewcharoenwong, Bianca Kessler, Prasong Khaenam, Ploenchan Chetchotisakd, Bernard Maillere, John Robinson, Catherine J. Reynolds, Rosemary J. Boyton, Daniel M. Altmann, Ganjana Lertmemongkolchai

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Burkholderia pseudomallei (Bp) is an environmental bacterial pathogen that causes potentially lethal sepsis in susceptible individuals and is considered a Category B, Tier-1 biothreat agent. As such, it is crucial to gain an improved understanding of

Externí odkaz: https://doaj.org/article/a3d0787df49748db8785d59378efca84