Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Catherine Howsham"'
Autor:
Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 64:7241-7260
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be
Autor:
Stephen Paul Collingwood, Jake Axford, Derek Paisley, Sarah Czarnecki, Catherine Howsham, Peter Hunt, Brian Cox, Nicholas James Devereux, Alice Young, Thomas Anthony Hunt, Kevin Coote, Victoria Paddock, Henry Danahay, Hazel C. Atherton-Watson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:929-932
We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational desig
Autor:
Helen Newson, Brian Cox, Andrew Lister, Sachini Herath, Christopher Thomson, Lisa Cooper, Catherine Howsham, Louise Eagling, María Paz Muñoz, Jose M. Alonso
Publikováno v:
Chemistry - A European Journal. 24:5989-5989
Autor:
Thomas Hunt, Hazel C. Atherton-Watson, Stephen P. Collingwood, Kevin J. Coote, Sarah Czarnecki, Henry Danahay, Catherine Howsham, Peter Hunt, Derek Paisley, Alice Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2877-2879
We report the synthesis and biological evaluation of a series of novel α-branched pyrazinoyl quaternary amines for their ability to block ion transport via the epithelial sodium channel (ENaC) in human bronchial epithelial cells (HBECs). Compound 12
Autor:
Henry Danahay, Catherine Howsham
Publikováno v:
Ion Channel Drug Discovery ISBN: 9781849731867
On a daily basis we can inhale up to 12,000 liters of air, and with this comes a wealth of particles including environmental pollutants, allergens and microbes that impact on the surface epithelium of the lung. The lungs maintain a sterile environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a38cc665030295fb41c666603bc8d6a6
https://doi.org/10.1039/9781849735087-00135
https://doi.org/10.1039/9781849735087-00135
Autor:
Catherine Howsham, Séverine Hebbe, Jean-François Basset, Anthony G. M. Barrett, Thomas Werner, Jan Bräckow, Sarah M. Major, Ismael Navarro
Publikováno v:
Journal of the American Chemical Society. 130(31)
Diketo-1,3-dioxin-2-ones underwent retro-Diels-Alder reaction on heating in toluene at 110 degrees C to generate alpha,gamma,-triketo-ketenes. These were trapped with alcohols to provide 2,4,6-triketocarboxylates, which were smoothly aromatized by se