Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine H. Trepanier"'
Autor:
Beverley A. Orser, Michael F. Jackson, Kai Yang, Catherine H. Trepanier, Gang Lei, Yu-Feng Xie, John F. MacDonald, Tadashi Yamamoto, Takanobu Nakazawa, Michael W. Salter, Hongbin Li, Bikram Sidhu
Publikováno v:
The EMBO Journal. 31:805-816
Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses in the hippocampus is mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc5632f1437eefff15dd22c2a383b90
https://doi.org/10.1038/emboj.2011.453
https://doi.org/10.1038/emboj.2011.453
Publikováno v:
FEBS Journal. 279:12-19
The phosphorylation and trafficking of N-methyl-d-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e3289e522bb2e94b59ac8a32e50a82d
https://doi.org/10.1111/j.1742-4658.2011.08391.x
https://doi.org/10.1111/j.1742-4658.2011.08391.x
Publikováno v:
Journal of Alzheimer's Disease. 21:1089-1099
Alzheimer's disease (AD) is currently treated with cholinergic and glutamatergic therapies, which provide symptomatic benefit but do not reverse the underlying pathology or cognitive deficits. The prevalence of AD is expected to triple over the next
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b069d71be8fcecf77b7db0188e4373
https://doi.org/10.3233/jad-2010-090667
https://doi.org/10.3233/jad-2010-090667
Autor:
Hongbin Li, John F. MacDonald, Michael F. Jackson, Kai Yang, Ethan A. Lerner, Catherine H. Trepanier, Michael A. Beazely
Publikováno v:
Hippocampus. 19:779-789
Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide, which belongs to a superfamily of structurally related peptide hormones including pituitary adenylate cyclase-activating polypeptide (PACAP). Although several studies have identified the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639f9cf7cc85b7f35f0eab60a9659863
https://doi.org/10.1002/hipo.20559
https://doi.org/10.1002/hipo.20559
Autor:
Ilyas S. Aleem, Hamid Reza Sadeghnia, Liqing Shen, O. Carter Snead, Catherine H. Trepanier, Ying Wu, Chen Chu Liu, Miguel A. Cortez, Asim Ashraf, Ashlin Kanawaty, Lee S. Stewart
Publikováno v:
Pediatric Research. 65:499-503
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6b56c4429c91dbbcedeab5409016d6
https://doi.org/10.1203/pdr.0b013e31819d9076
https://doi.org/10.1203/pdr.0b013e31819d9076
Autor:
Bikram Sidhu, John F. MacDonald, Xuanmao Chen, Catherine H. Trepanier, Aeni Lim, Hongbin Li, Michael A. Beazely
Publikováno v:
Journal of Biological Chemistry. 284:8054-8063
Platelet-derived growth factor (PDGF) beta receptor activation inhibits N-methyl-d-aspartate (NMDA)-evoked currents in hippocampal and cortical neurons via the activation of phospholipase Cgamma, PKC, the release of intracellular calcium, and a rearr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dc723d5ada2262a22abcca5d81b839
https://doi.org/10.1074/jbc.m805384200
https://doi.org/10.1074/jbc.m805384200
Publikováno v:
Scientific Reports
Group II metabotropic glutamate receptors (mGluR2/3) have emerged as important targets for the treatment of schizophrenia. Since hypofunction of N-methyl-D-aspartate receptors (NMDARs) has also been implicated in the etiology of schizophrenia, we exa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55bfbe44f4f806a7c574c4921ec35d3
Publikováno v:
The FEBS journal. 279(1)
The phosphorylation and trafficking of N-methyl-d-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbe4519aad4ff476bce8341385dd4359
https://pubmed.ncbi.nlm.nih.gov/21985328
https://pubmed.ncbi.nlm.nih.gov/21985328
Autor:
Michael F. Jackson, Kai Yang, Jillian C. Belrose, Gang Lei, Catherine H. Trepanier, John F. MacDonald
Publikováno v:
Journal of Alzheimer's disease : JAD. 27(2)
Alzheimer's disease (AD) is the most common form of dementia characterized by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles. The mechanisms leading to AD are not completely understood; however, recent evidence suggests that alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf1b61d86fe13ab95ce8cafc279b6a6
https://pubmed.ncbi.nlm.nih.gov/21799250
https://pubmed.ncbi.nlm.nih.gov/21799250
Autor:
Beverley A. Orser, Catherine H. Trepanier, Michael W. Salter, Hongbin Li, John F. MacDonald, Michael F. Jackson, Kai Yang
Publikováno v:
Hippocampus. 21(10)
The induction of long-term potentiation (LTP) of CA3-CA1 synapses requires activation of postsynaptic N-methyl-D-aspartate receptors (GluNRs). At resting potential, the contribution of GluNRs is limited by their voltage-dependent block by extracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860e43baf4064b98382341952206b523
https://pubmed.ncbi.nlm.nih.gov/20865743
https://pubmed.ncbi.nlm.nih.gov/20865743