Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Catherine H Freudenreich"'
Autor:
Rebecca E Brown, Xiaofeng A Su, Stacey Fair, Katherine Wu, Lauren Verra, Robyn Jong, Kristin Andrykovich, Catherine H Freudenreich
Publikováno v:
PLoS Biology, Vol 20, Iss 12, p e3001940 (2022)
Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat instability
Externí odkaz:
https://doaj.org/article/4e5e87cf75114ffc87feeec5e2eda3e1
Autor:
Michaela A Gold, Jenna M Whalen, Karine Freon, Zixin Hong, Ismail Iraqui, Sarah A E Lambert, Catherine H Freudenreich
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009863 (2021)
Disease-associated trinucleotide repeats form secondary DNA structures that interfere with replication and repair. Replication has been implicated as a mechanism that can cause repeat expansions and contractions. However, because structure-forming re
Externí odkaz:
https://doaj.org/article/217d60e344ba4718b05f2866338cb4b1
Autor:
Nealia CM House, Erica J Polleys, Ishtiaque Quasem, Marjorie De la Rosa Mejia, Cailin E Joyce, Oliver Takacsi-Nagy, Jocelyn E Krebs, Stephen M Fuchs, Catherine H Freudenreich
Publikováno v:
eLife, Vol 8 (2019)
CAG/CTG trinuncleotide repeats are fragile sequences that when expanded form DNA secondary structures and cause human disease. We evaluated CAG/CTG repeat stability and repair outcomes in histone H2 mutants in S. cerevisiae. Although the two copies o
Externí odkaz:
https://doaj.org/article/9a8483e0f83b486799cefa574f9e9f22
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001339 (2011)
Repetitive DNA elements are mutational hotspots in the genome, and their instability is linked to various neurological disorders and cancers. Although it is known that expanded trinucleotide repeats can interfere with DNA replication and repair, the
Externí odkaz:
https://doaj.org/article/7ba031b297aa4acc9580110dfbf4a8e8
Autor:
Lionel Gellon, David F Razidlo, Olive Gleeson, Lauren Verra, Danae Schulz, Robert S Lahue, Catherine H Freudenreich
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001298 (2011)
Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replicati
Externí odkaz:
https://doaj.org/article/df62359b7a2d48c093fd41e76a685e52
Autor:
Eric T. Wang, Catherine H. Freudenreich, Natalia Gromak, Ankur Jain, Peter K. Todd, Yoshitaka Nagai
Publikováno v:
Molecular Cell. 83:324-329
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d39aeeb3abdfa84e30f639cff61e51
https://doi.org/10.1016/j.molcel.2022.12.017
https://doi.org/10.1016/j.molcel.2022.12.017
Publikováno v:
Nature Communications. 14
Expanded CAG/CTG repeats are sites of DNA damage, leading to repeat length changes. Homologous recombination (HR) is one cause of repeat instability and we hypothesized that gap filling was a driver of repeat instability during HR. To test this, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d57619106eda90c66ab1fde1c2045e13
https://doi.org/10.1038/s41467-023-37901-2
https://doi.org/10.1038/s41467-023-37901-2
Publikováno v:
Curr Opin Genet Dev
Many microsatellite DNA sequences are able to form non-B form DNA secondary structures, such as hairpin loops, cruciforms, triplex DNA or G-quadruplexes. These DNA structures can form a significant impediment to DNA replication and repair, leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ae8e741f82479da8f5ae17253a2fba
https://doi.org/10.1016/j.gde.2021.08.005
https://doi.org/10.1016/j.gde.2021.08.005
Autor:
Lata Balakrishnan, Yanhao Lai, Eduardo E. Laverde, Yuan Liu, Catherine H. Freudenreich, Fenfei Leng
Publikováno v:
J Biol Chem
Trinucleotide repeat (TNR) expansion and deletion are responsible for over 40 neurodegenerative diseases and associated with cancer. TNRs can undergo somatic instability that is mediated by DNA damage and repair and gene transcription. Recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9819acdf7afc1065f7bf57ddfcdfec47
https://doi.org/10.1074/jbc.ra120.014161
https://doi.org/10.1074/jbc.ra120.014161
Autor:
Rebecca E. Brown, Xiaofeng A. Su, Stacey Fair, Katherine Wu, Lauren Verra, Robyn Jong, Kristin Andrykovich, Catherine H. Freudenreich
Publikováno v:
PLoS biology. 20(12)
Expansion of structure-forming CAG/CTG repetitive sequences is the cause of several neurodegenerative disorders and deletion of repeats is a potential therapeutic strategy. Transcription-associated mechanisms are known to cause CAG repeat instability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afee7be703d25307eba247851977320
https://pubmed.ncbi.nlm.nih.gov/36574440
https://pubmed.ncbi.nlm.nih.gov/36574440