Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine H, Trepanier"'
Autor:
Beverley A. Orser, Michael F. Jackson, Kai Yang, Catherine H. Trepanier, Gang Lei, Yu-Feng Xie, John F. MacDonald, Tadashi Yamamoto, Takanobu Nakazawa, Michael W. Salter, Hongbin Li, Bikram Sidhu
Publikováno v:
The EMBO Journal. 31:805-816
Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses in the hippocampus is mediate
Publikováno v:
FEBS Journal. 279:12-19
The phosphorylation and trafficking of N-methyl-d-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point
Publikováno v:
Journal of Alzheimer's Disease. 21:1089-1099
Alzheimer's disease (AD) is currently treated with cholinergic and glutamatergic therapies, which provide symptomatic benefit but do not reverse the underlying pathology or cognitive deficits. The prevalence of AD is expected to triple over the next
Autor:
Hongbin Li, John F. MacDonald, Michael F. Jackson, Kai Yang, Ethan A. Lerner, Catherine H. Trepanier, Michael A. Beazely
Publikováno v:
Hippocampus. 19:779-789
Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide, which belongs to a superfamily of structurally related peptide hormones including pituitary adenylate cyclase-activating polypeptide (PACAP). Although several studies have identified the
Autor:
Ilyas S. Aleem, Hamid Reza Sadeghnia, Liqing Shen, O. Carter Snead, Catherine H. Trepanier, Ying Wu, Chen Chu Liu, Miguel A. Cortez, Asim Ashraf, Ashlin Kanawaty, Lee S. Stewart
Publikováno v:
Pediatric Research. 65:499-503
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hyp
Autor:
Bikram Sidhu, John F. MacDonald, Xuanmao Chen, Catherine H. Trepanier, Aeni Lim, Hongbin Li, Michael A. Beazely
Publikováno v:
Journal of Biological Chemistry. 284:8054-8063
Platelet-derived growth factor (PDGF) beta receptor activation inhibits N-methyl-d-aspartate (NMDA)-evoked currents in hippocampal and cortical neurons via the activation of phospholipase Cgamma, PKC, the release of intracellular calcium, and a rearr
Publikováno v:
Scientific Reports
Group II metabotropic glutamate receptors (mGluR2/3) have emerged as important targets for the treatment of schizophrenia. Since hypofunction of N-methyl-D-aspartate receptors (NMDARs) has also been implicated in the etiology of schizophrenia, we exa
Publikováno v:
The FEBS journal. 279(1)
The phosphorylation and trafficking of N-methyl-d-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point
Autor:
Michael F. Jackson, Kai Yang, Jillian C. Belrose, Gang Lei, Catherine H. Trepanier, John F. MacDonald
Publikováno v:
Journal of Alzheimer's disease : JAD. 27(2)
Alzheimer's disease (AD) is the most common form of dementia characterized by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles. The mechanisms leading to AD are not completely understood; however, recent evidence suggests that alt
Autor:
Beverley A. Orser, Catherine H. Trepanier, Michael W. Salter, Hongbin Li, John F. MacDonald, Michael F. Jackson, Kai Yang
Publikováno v:
Hippocampus. 21(10)
The induction of long-term potentiation (LTP) of CA3-CA1 synapses requires activation of postsynaptic N-methyl-D-aspartate receptors (GluNRs). At resting potential, the contribution of GluNRs is limited by their voltage-dependent block by extracellul