Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Catherine H, Régnier"'
Autor:
Peter A. Bell, Sophia Scheuermann, Florian Renner, Christina L. Pan, Henry Y. Lu, Stuart E. Turvey, Frédéric Bornancin, Catherine H. Régnier, Christopher M. Overall
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4717-4732 (2022)
We developed a bioinformatics-led substrate discovery workflow to expand the known substrate repertoire of MALT1. Our approach, termed GO-2-Substrates, integrates protein function information, including GO terms from known substrates, with protein se
Externí odkaz:
https://doaj.org/article/ee670d72d28541c29c6af4f17e092816
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 11K, Activity of NVP-BBT594 in biochemical and cell-based assays. The IC50 (mean of two experiments) of NVP-BBT594 on the JAK2 kinase was determined in a biochemical kinase assay with the active enzyme. Half-maximal growth inhibition (GI50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31418f731a67ae71f974979b4eddf70
https://doi.org/10.1158/2159-8290.22528298
https://doi.org/10.1158/2159-8290.22528298
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
The recent discovery of an acquired activating point mutation in JAK2, substituting valine at amino acid position 617 for phenylalanine, has greatly improved our understanding of the molecular mechanism underlying chronic myeloproliferative neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7997e164cd9af3cf9ffb6c692aca1cec
https://doi.org/10.1158/1535-7163.c.6531816
https://doi.org/10.1158/1535-7163.c.6531816
Autor:
Thomas Radimerski, Francesco Hofmann, Lorenza Wyder, Markus Wartmann, Eric Vangrevelinghe, Joerg Trappe, Stephan Ruetz, Lynda Nolan, David Ledieu, Marc Lang, Marc Gerspacher, Pascal Furet, Dirk Erdmann, Peter Drueckes, Patrick Chène, Josef Brueggen, Francesca Blasco, Gisele A. Tavares, Carole Pissot-Soldermann, Alain De Pover, Catherine H. Régnier, Fabienne Baffert
Supplementary Data from Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9b8ce3cdd08cb9653d9038e050b02d
https://doi.org/10.1158/1535-7163.22485180.v1
https://doi.org/10.1158/1535-7163.22485180.v1
Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.
Autor:
Stefanie Ginster, Maureen Bardet, Adeline Unterreiner, Claire Malinverni, Florian Renner, Stephen Lam, Felix Freuler, Bertran Gerrits, Johannes Voshol, Thomas Calzascia, Catherine H Régnier, Martin Renatus, Rainer Nikolay, Laura Israël, Frédéric Bornancin
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169026 (2017)
The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors. Recruitment of MALT1 into activation complexes is required for MALT1 proteolytic function. Here, co-expression of MALT1 in HEK293 cells, eit
Externí odkaz:
https://doaj.org/article/eb964b7c33aa4a88896450133128fd32
Autor:
Marc Bigaud, Achim Schlapbach, Ina Dix, Ralf Endres, Jean Quancard, Jutta Blank, Frédéric Bornancin, Markus Wartmann, Julien Scesa, Paulo Antonio Fernandes Gomes Dos Santos, Eva Altmann, Thomas Radimerski, Guido Bold, Nicole Buschmann, Samu Melkko, Andreas Weiss, Paul W. Manley, P. Erbel, Oliver Simic, Thomas Zoller, Catherine H. Régnier, Ansgar Schuffenhauer, Elisabeth Buchdunger, Martin Renatus, Paul M.J. McSheehy, Carole Pissot Soldermann
Publikováno v:
Journal of Medicinal Chemistry. 63:14576-14593
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9969a4c36550186a210fdfae8c1af415
https://doi.org/10.1021/acs.jmedchem.0c01245
https://doi.org/10.1021/acs.jmedchem.0c01245
Autor:
Jean Quancard, Laurence Kieffer, Samu Melkko, Ralf Endres, Martin Renatus, Catherine H. Régnier, Thomas Calzascia, Mickael Sorge, Markus Wartmann, Frédéric Bornancin, Thomas Radimerski, P. Erbel, Carole Pissot Soldermann, Paul M.J. McSheehy, Markus Blatter, Reiner Aichholz, Trixie Wagner, Oliver Simic, Karen Beltz, Marc Bigaud, Achim Schlapbach, Andreas Weiss
Publikováno v:
Journal of Medicinal Chemistry. 63:14594-14608
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds to explore the therapeutic potential of this target. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a7c1ce6f98fa56490d44e94ead5daa
https://doi.org/10.1021/acs.jmedchem.0c01246
https://doi.org/10.1021/acs.jmedchem.0c01246
Autor:
Amanda Littlewood-Evans, Sophie Sarret, Frédéric Bornancin, Yeter Kolb, Isabelle Isnardi, Jean Quancard, Grazyna Wieczorek, Hans-Guenter Zerwes, Achim Schlapbach, Ratiba Touil, Nadja Caesar, Stephanie Valeaux, Karen Beltz, Thomas Le Meur, Maureen Bardet, Christian Beerli, Jiri Kovarik, Tobias Junt, Thomas Calzascia, Kea Martin, Catherine H. Régnier, Marc Bigaud, Laura Israel, Grozdan Cvijetic, Elena Degl'Innocenti
Publikováno v:
Arthritis & Rheumatology. 72:919-930
Objective Fcγ receptors (FcγR) play important roles in both protective and pathogenic immune responses. The assembly of the CBM signalosome encompassing caspase recruitment domain-containing protein 9, B cell CLL/lymphoma 10, and mucosa-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d875d2102180de2a6699c3ac5aa48f6
https://doi.org/10.1002/art.41204
https://doi.org/10.1002/art.41204
Autor:
Carole, Pissot Soldermann, Oliver, Simic, Martin, Renatus, Paulus, Erbel, Samu, Melkko, Markus, Wartmann, Marc, Bigaud, Andreas, Weiss, Paul, McSheehy, Ralf, Endres, Paulo, Santos, Jutta, Blank, Ansgar, Schuffenhauer, Guido, Bold, Nicole, Buschmann, Thomas, Zoller, Eva, Altmann, Paul W, Manley, Ina, Dix, Elisabeth, Buchdunger, Julien, Scesa, Jean, Quancard, Achim, Schlapbach, Frédéric, Bornancin, Thomas, Radimerski, Catherine H, Régnier
Publikováno v:
Journal of medicinal chemistry. 63(23)
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of a high-throughput biochemical screening hit resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c9148f487b1a8d48b0cb731fa2d9337
https://pubmed.ncbi.nlm.nih.gov/33252239
https://pubmed.ncbi.nlm.nih.gov/33252239