Výsledky vyhledávání - "Catherine Guerreiro"

A convergent chemoenzymatic strategy to deliver a diversity of Shigella flexneri serotype-specific O-antigen segments from a unique lightly protected tetrasaccharide core

Autor: Akli Ben Imeddourene, Guillaume Le Heiget, Claire Moulis, Isabelle André, Zhaoyu Hu, Nelly Monties, Laurence A. Mulard, Magali Remaud-Simeon, Mounir Benkoulouche, Louis-Antoine Barel, Catherine Guerreiro, Yann Le Guen

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, 2021, 86 (3), pp.2058-2075. ⟨10.1021/acs.joc.0c00777⟩
Journal of Organic Chemistry, American Chemical Society, 2020, 86 (3), pp.2058-2075. ⟨10.1021/acs.joc.0c00777⟩

International audience; Progress in glycoscience is strongly dependent on the availability of broadly diverse tailored-made, well-defined and often complex oligosaccharides. Herein, going beyond natural resources and aiming to circumvent chemical bou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9424a376996bb908628ac2d5c4f976e
https://hal.insa-toulouse.fr/hal-03020947/document

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Convergent Chemoenzymatic Strategy to Deliver a Diversity of

Autor: Zhaoyu, Hu, Mounir, Benkoulouche, Louis-Antoine, Barel, Guillaume, Le Heiget, Akli, Ben Imeddourene, Yann, Le Guen, Nelly, Monties, Catherine, Guerreiro, Magali, Remaud-Siméon, Claire, Moulis, Isabelle, André, Laurence A, Mulard

Publikováno v: The Journal of organic chemistry. 86(3)

Progress in glycoscience is strongly dependent on the availability of broadly diverse tailor-made, well-defined, and often complex oligosaccharides. Herein, going beyond natural resources and aiming to circumvent chemical boundaries in glycochemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe7e8c5c8624fd9471ff197e5ae0344a
https://pubmed.ncbi.nlm.nih.gov/32700907

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Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy forShigella flexneri 3a

Autor: Laurence A. Mulard, Ana Ardá, F. Javier Cañada, Armelle Phalipon, Pilar Blasco, Françoise Thouron, Catherine Guerreiro, Jesús Jiménez-Barbero, Farida Nato, Sylvie Dartevelle, Julien Boutet

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, 2016, 22 (31), pp.10892-10911. ⟨10.1002/chem.201600567⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2016, 22 (31), pp.10892-10911. ⟨10.1002/chem.201600567⟩

International audience; Shigella flexneri 3a causes bacillary dysentery. Its O-antigen has the {2)-[α-d-Glcp-(1→3)]-α-l-Rhap-(1→2)-α-l-Rhap-(1→3)-[Ac→2]-α-l-Rhap-(1→3)-[Ac→6]≈40 % -β-d-GlcpNAc-(1→} ([(E)ABAc CAc D]) repeating uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6b2b38ddd316d00de09b2b30e93ec3
https://doi.org/10.1002/chem.201600567

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Structural Studies of theO-Acetyl-Containing O-Antigen from aShigella flexneriSerotype 6 Strain and Synthesis of Oligosaccharide Fragments Thereof

Autor: Göran Widmalm, Pierre Chassagne, Laurence A. Mulard, Catherine Guerreiro, Armelle Phalipon, Charles Gauthier, Carolina Fontana

Publikováno v: European Journal of Organic Chemistry. 2013:4085-4106

Extensive analysis by NMR spectroscopy of the delipidated lipopolysaccharide of Shigella flexneri serotype 6 strain MDC 2924-71 confirmed the most recently reported structure of the O-antigen repeating unit as {→4)-β-D-GalpA-(1→3)-β-D-GalpNAc-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d217e4e6515fa0fac71aa7d5cd0aee43
https://doi.org/10.1002/ejoc.201300180

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A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

Autor: Laurence A. Mulard, Catherine Guerreiro, Philippe J. Sansonetti, Françoise Thouron, Peter Hoogerhout, Michiel Stork, Tae Hee Kim, Armelle Phalipon, Janny Westdijk, Robert M. F. van der Put

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2016, 27 (4), pp.883-92. ⟨10.1021/acs.bioconjchem.5b00617⟩
Bioconjugate Chemistry, 2016, 27 (4), pp.883-92. ⟨10.1021/acs.bioconjchem.5b00617⟩

International audience; Conjugation chemistry is among the most important parameters governing the efficacy of glycoconjugate vaccines. High robustness is required to ensure high yields and batch to batch reproducibility. Herein, we have established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d49e93a5c0c5688aa7d2a62c455911
https://hal-pasteur.archives-ouvertes.fr/pasteur-01350027

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Efficient route to orthogonally protected precursors of 2-acylamino-2-deoxy-3-O-substituted-β-d-glucopyranose derivatives and use thereof

Autor: Laurence A. Mulard, Tae Hee Kim, Julien Boutet, Catherine Guerreiro

Publikováno v: Tetrahedron Letters. 49:5339-5342

An efficient route to two 3-O-acyl-2-deoxy-4,6-O-isopropylidene-2-trichloroacetamido- d -glucopyranosyl trichloroacetimidate donors is reported. As demonstrated for the 3-O-acetyl derivative, these building blocks are exquisite β- d -glucosamine don

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c996e175a6fc86fe74f0018c4196434
https://doi.org/10.1016/j.tetlet.2008.06.052

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Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

Autor: Isabelle André, Laurence A. Mulard, Emmanuelle Cambon, Magali Remaud-Simeon, Catherine Guerreiro, Stéphane Salamone

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2015, 51 (13), pp.2581-2584. ⟨10.1039/c4cc08805k⟩
Chemical Communications, 2015, 51 (13), pp.2581-2584. ⟨10.1039/c4cc08805k⟩

The powerful chemo-enzymatic synthesis of the pentadecasaccharide hapten involved in the first synthetic carbohydrate-based vaccine candidate against endemic shigellosis is reported. The high yielding site-selective alpha-D-glucosylation of a lightly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb6b078fe28ad02c619b1db457191fb
https://hal.archives-ouvertes.fr/hal-01269073

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BORANO-NUCLEOTIDES: NEW ANALOGUES TO CIRCUMVENT HIV-1 RT-MEDIATED NUCLEOSIDE DRUG-RESISTANCE

Autor: Karine Barral, Karine Alvarez, Boulbaba Selmi, Laurence A. Mulard, Bruno Canard, Catherine Guerreiro, Joëlle Boretto, Robert Sarfati, Jerome Deval

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2005, 24 (5-7), pp.419-422. ⟨10.1081/NCN-200059951⟩
Nucleosides, Nucleotides and Nucleic Acids, 2005, 24 (5-7), pp.419-422. ⟨10.1081/NCN-200059951⟩

International audience; Alpha-boranophosphates suppress RT-mediated resistance when the catalytic rate of incorporation (kpol) of the analogue 5'-triphosphate is responsable for drug resistance, such as in the case of K65R mutant and ddNTPs, and Q151

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fa8adee3bd8b1430548b6cff548dc9
https://doi.org/10.1081/ncn-200059951

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Total synthesis of a tetra- and two pentasaccharide fragments of the O-specific polysaccharide of Shigella flexneri serotype 2a

Autor: Laurence A. Mulard, Catherine Guerreiro

Publikováno v: Tetrahedron. 60:2475-2488

The synthesis of the methyl glycoside of the branched pentasaccharide biological repeating unit of the O-antigen of Shigella flexneri serotype 2a is described together with that of the methyl glycoside of the corresponding tetrasaccharide and frame-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63956e02f823589d445419052ed84d7c
https://doi.org/10.1016/j.tet.2004.01.054

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