Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Catherine Foy"'
Autor:
Eileen Daly, Gillian Baird, Sarah Curran, Declan G. Murphy, Ronan M. Conroy, Ruth L. O'Gorman, Lisa Page, Brian Hallahan, Finian M. O'Brien, Dene Robertson, Ajay Sharma, Kieran C. Murphy, Catherine Foy, Patrick Bolton
Publikováno v:
Psychiatry Research: Neuroimaging. 184:77-85
People with autistic spectrum disorders (ASD, including Asperger syndrome) may have developmental abnormalities in the amygdala-hippocampal complex (AHC). However, in vivo, age-related comparisons of both volume and neuronal integrity of the AHC have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006d58e08e96344100c191e777839e9d
https://doi.org/10.1016/j.pscychresns.2010.08.007
https://doi.org/10.1016/j.pscychresns.2010.08.007
Autor:
Allison Cooper, Andrew Simmons, Lars-Olof Wahlund, Michaella Poppe, Catherine Foy, Declan G. Murphy, Eric Westman, Christian Spenger, Simon Lovestone
Publikováno v:
Journal of Alzheimer's Disease. 22:171-181
Alzheimer's disease (AD) is the most common neurodegenerative disorder among the elderly, and early detection is of great importance if new therapies are to be effectively administered. We have used multivariate data analysis (orthogonal partial leas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7365dc03054549929e45471979db51
https://doi.org/10.3233/jad-2010-100168
https://doi.org/10.3233/jad-2010-100168
Autor:
Helen Nicholas, Stephanie Bryant, Harry Boothby, Paul Moran, Catherine Foy, Simon Lovestone, Richard G. Brown
Publikováno v:
International Journal of Geriatric Psychiatry. 25:345-351
Objective To examine the association between premorbid personality traits, social networks and AD, using a case-control design, and two informant-based retrospective assessments of premorbid personality. Methods Cases consisted of 217 Subjects diagno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2e94ddbacf398dcca84052ce0627d1
https://doi.org/10.1002/gps.2345
https://doi.org/10.1002/gps.2345
Autor:
Amanda Glover, Catherine Foy, Abdul Hye, Madhav Thambisetty, Eileen Daly, Allison Cooper, Declan G. Murphy, Andrew Simmons, Simon Lovestone
Publikováno v:
Journal of Neurology. 255:1712-1720
There is an urgent need for peripheral surrogates of Alzheimer's disease (AD) that accurately reflect disease state and severity as well as correlate with key features of its neuropathology. The aim of this study was to identify plasma proteins assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e74ce7d34c9bc201648703c3ef261e2
https://doi.org/10.1007/s00415-008-0006-8
https://doi.org/10.1007/s00415-008-0006-8
Autor:
Valentina Moskvina, Simon Lovestone, Paul Hollingworth, Catherine Foy, Michael Gill, Julie Williams, Marian L. Hamshere, David C. Rubinsztein, Aoibhinn Lynch, Pamela Moore, Brian A. Lawlor, Carol Brayne, Kimberley Dowzell, N. Archer, Michael John Owen
Publikováno v:
Journal of the American Geriatrics Society. 54:1348-1354
OBJECTIVES: To investigate behavioral components of Alzheimer's disease (AD) and to analyze behavioral components in relation to disease severity, apolipoprotein E genotype (APOE), sex, years of education, age at onset, and cognitive impairment. DESI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95d694f9671652f3f2ae2d1296aa066
https://doi.org/10.1111/j.1532-5415.2006.00854.x
https://doi.org/10.1111/j.1532-5415.2006.00854.x
Autor:
Michael John Owen, John J. Sninsky, Michael Conlon O'Donovan, Anthony L. Hinrichs, Sara Cherny, Ryan van Luchene, John Powell, Yonghong Li, Catherine Foy, John Hardy, Fabienne Wavrant-De Vrièze, Taylor J. Maxwell, Petra Nowotny, Lisa Doil, Peter Holmans, Leon J. Thal, Simon Lovestone, Nicola Archer, Christopher Morris, John C. Morris, Charles M. Rowland, Scott Smemo, Alison Goate, Joseph J. Catanese, Luke Jehu, Julie Williams, Lesley Jones, John S. K. Kauwe, Paul Hollingworth, Gillian Hamilton, Mona Kaleem, Amanda J. Myers, Kristina Tacey, Andrew Grupe, Thomas J. White
Publikováno v:
The American Journal of Human Genetics. 78:78-88
Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Although significant associations with several biological candidate ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f449836cbe0fc6d45cf088c57c39dcf7
https://doi.org/10.1086/498851
https://doi.org/10.1086/498851
Autor:
Paul Hollingworth, Nigel J. Cairns, Lynnette J. Cook, David C. Rubinsztein, Edith Terrenoire, Simon Lovestone, Carol Brayne, Amanda J. Edmondson, Luke Jehu, Pamela Moore, Catherine Foy, Nicola Archer, Lin Wang, Sarah Walter, John Powell, John H. Xuereb, Julie Williams, D. Turic, John Grimley Evans, Luk W. Ho
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :5-8
Consistent deficits in the cholinergic system are evident in the brains of Alzheimer's Disease (AD) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (AChE), and choline acetyltransferase (ChAT), increased butyry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c28298eb8653447a8aeb89a6fddd64
https://doi.org/10.1002/ajmg.b.30068
https://doi.org/10.1002/ajmg.b.30068
Autor:
Pamela Moore, John Hardy, Ryan van Luchene, Kit Lau, Julie Williams, Catherine Foy, Simon Lovestone, Joseph J. Cantanese, Petra Nowotny, Nicola Archer, Lisa Doil, John C. Morris, John J. Sninsky, John Powell, Kristina Tacey, Andrew Grupe, Veronica Garcia, Michael Conlon O'Donovan, Leon J. Thal, Michael John Owen, Alison Goate, Charles M. Rowland, Paul Hollingworth, Peter Holmans, Yonghong Li
Publikováno v:
Human Mutation. 25:270-277
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e6e86836b43f812196f24e942c57d1
https://doi.org/10.1002/humu.20138
https://doi.org/10.1002/humu.20138
Autor:
Corinne Lendon, Sarah Walter, D. Turic, John Grimley Evans, Antonia L. Pritchard, Amanda J. Edmondson, Lynnette J. Cook, Pamela Moore, Nigel J. Cairns, Alison Taylor, Helen Lemmon, John H. Xuereb, Catherine Foy, Luk W. Ho, Paul Hollingworth, Julie Williams, David M. A. Mann, David C. Rubinsztein, Michael John Owen, Luke Jehu, Simon Lovestone, Nicola Archer, David St Clair, Carol Brayne, John Powell
Publikováno v:
Neuroscience Letters. 358:142-146
Consistent deficits in the cholinergic system are evident in Alzheimer's disease (AD) patients, including selective loss of alpha4beta2 nicotinic acetylcholine receptors in the brains of AD patients. Knockout mice for the beta2 subunit have impaired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e0b1b653b169f4d06201db03869de2
https://doi.org/10.1016/j.neulet.2004.01.016
https://doi.org/10.1016/j.neulet.2004.01.016
Autor:
Peter Holmans, Joanne Norton, John Hardy, Kit Lau, Jolanda van Hengel, Gillian Hamilton, Pamela Moore, Luke Jehu, C. Lendon, Andrew Grupe, Sarah Walter, Kristina Tacey, Stuart Pickering-Brown, Takeshi Iwatsubo, Daniel Woo, Richard Killick, Meredith Womick, John Powell, Victoria L. Busby, Paul Hollingworth, Denise Harold, Danielle Compton, Petra Nowotny, Alison Goate, Lisa Doil, Barbara Janssens, David M. A. Mann, John C. Morris, Frans van Roy, Amanda J. Myers, Lesley Jones, Safa Al-Saraj, Michael John Owen, Simon Lovestone, Nicola Archer, Catherine Foy, Michael Conlon O'Donovan, Scott Smemo, Julie Williams, Steven Goossens, D. Turic
Publikováno v:
NeuroMolecular Medicine. 5:133-146
The gene encoding alpha-T-catenin, CTNNA3, is positioned within a region on chromosome 10, showing strong evidence of linkage to Alzheimer's disease (AD), and is therefore a good positional candidate gene for this disorder. We have demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b26504dbb18c7aabd01bdf49ee7b58
https://doi.org/10.1385/nmm:5:2:133
https://doi.org/10.1385/nmm:5:2:133