Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Catherine F. Hatton"'
Autor:
Catherine F. Hatton, Rachel A. Botting, Maria Emilia Dueñas, Iram J. Haq, Bernard Verdon, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Florian Gothe, Emily Stephenson, Aaron I. Gardner, Sandra Murphy, Jonathan Scott, James P. Garnett, Sean Carrie, Jason Powell, C. M. Anjam Khan, Lei Huang, Rafiqul Hussain, Jonathan Coxhead, Tracey Davey, A. John Simpson, Muzlifah Haniffa, Sophie Hambleton, Malcolm Brodlie, Chris Ward, Matthias Trost, Gary Reynolds, Christopher J. A. Duncan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-C
Externí odkaz:
https://doaj.org/article/0c29a923bed447a88b3b4df91dd15100
Autor:
Aidan T. Hanrath, Catherine F. Hatton, Florian Gothe, Cathy Browne, Jane Vowles, Peter Leary, Simon J. Cockell, Sally A. Cowley, William S. James, Sophie Hambleton, Christopher J. A. Duncan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Macrophages are key target cells of Zika virus (ZIKV) infection, implicated as a viral reservoir seeding sanctuary sites such as the central nervous system and testes. This rests on the apparent ability of macrophages to sustain ZIKV replication with
Externí odkaz:
https://doaj.org/article/7b7909c2b1294e159f14f7444c6593f6
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the host innate immune response in pathogenes
Externí odkaz:
https://doaj.org/article/1fdfd80c308f4c00a7c3d8ca1ca2a146
Autor:
Aidan T. Hanrath, Catherine F. Hatton, Florian Gothe, Cathy Browne, Jane Vowles, Peter Leary, Simon J. Cockell, Sally A. Cowley, William S. James, Sophie Hambleton, Christopher J. A. Duncan
The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::645444488c80693d5628e4192c504f28
https://doi.org/10.1101/2022.03.09.483671
https://doi.org/10.1101/2022.03.09.483671
Autor:
Zofia Klimova, Linh Truong, Martina Fejtkova, Venetia Bigley, Dusana Moravcikova, Catherine F Hatton, Dipayan Mitra, Angela Grainger, Florian Gothe, Veronika Kanderova, Sophie Hambleton, Ales Janda, Joanna E. Perthen, Christopher J A Duncan, Eva Fronkova
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
We present a case of complete deficiency of the interferon alpha/beta receptor alpha chain (IFNAR1) in a child with fatal systemic hyperinflammation, apparently provoked by live-attenuated viral vaccination. Such pathologic hyperinflammation, fulfill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebf70cff48015dde8239b40748ee970
http://europepmc.org/articles/PMC8752251
http://europepmc.org/articles/PMC8752251
Autor:
Christopher J.A. Duncan, Morten K. Skouboe, Sophie Howarth, Anne K. Hollensen, Rui Chen, Malene L. Børresen, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Catherine F. Hatton, Frederik F. Stæger, Mette K. Andersen, John Whittaker, Søren R. Paludan, Sofie E. Jørgensen, Martin K. Thomsen, Jacob G. Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F. Øbro, Jakob T. Bay, Hanne V. Marquart, M. Teresa de la Morena, Joseph A. Klejka, Matthew Hirschfeld, Line Borgwardt, Isabel Forss, Tania Masmas, Anja Poulsen, Francisco Noya, Guy Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J. Allenspach, Sophie Hambleton, Trine H. Mogensen
Publikováno v:
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Spegarova, J S, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, Morena, M T D L, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Duncan, C J A, Skouboe, M K, Howarth, S, Hollensen, A K, Chen, R, Børresen, M L, Thompson, B J, Stremenova Spegarova, J, Hatton, C F, Stæger, F F, Andersen, M K, Whittaker, J, Paludan, S R, Jørgensen, S E, Thomsen, M K, Mikkelsen, J G, Heilmann, C, Buhas, D, Øbro, N F, Bay, J T, Marquart, H V, de la Morena, M T, Klejka, J A, Hirschfeld, M, Borgwardt, L, Forss, I, Masmas, T, Poulsen, A, Noya, F, Rouleau, G, Hansen, T, Zhou, S, Albrechtsen, A, Alizadehfar, R, Allenspach, E J, Hambleton, S & Mogensen, T H 2022, ' Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic ', The Journal of Experimental Medicine, vol. 219, no. 6, e20212427 . https://doi.org/10.1084/jem.20212427
Type I interferons (IFN-I) play a critical role in human antiviral immunity, as demonstrated by the exceptionally rare deleterious variants of IFNAR1 or IFNAR2. We investigated five children from Greenland, Canada, and Alaska presenting with viral di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0e93df69405efb9dfa8932bb4d0da2
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
https://curis.ku.dk/portal/da/publications/lifethreatening-viral-disease-in-a-novel-form-of-autosomal-recessive-ifnar2-deficiency-in-the-arctic(38e5d906-7ed0-4521-981d-02d7dbdab48d).html
Autor:
Robert M Jackson, Catherine F Hatton, Jarmila Stremenova Spegarova, Maria Georgiou, Joseph Collin, Emily Stephenson, Bernard Verdon, Iram J Haq, Rafiqul Hussain, Jonathan M Coxhead, Hardeep-Singh Mudhar, Bart Wagner, Megan Hasoon, Tracey Davey, Paul Rooney, C.M. Anjam Khan, Chris Ward, Malcolm Brodlie, Muzlifah Haniffa, Sophie Hambleton, Lyle Armstrong, Francisco Figueiredo, Rachel Queen, Christopher J A Duncan, Majlinda Lako
Publikováno v:
Stem cell reports. 17(7)
Although tropism of SARS-CoV-2 for respiratory tract epithelial cells is well established, an open question is whether the conjunctival epithelium is also a target for SARS-CoV-2. Conjunctival epithelial cells, which express viral entry receptors ACE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab674592947260fe7f29d2d14beff1d
https://pubmed.ncbi.nlm.nih.gov/35750043
https://pubmed.ncbi.nlm.nih.gov/35750043
Autor:
Rachel A. Botting, Bernard Verdon, Jason Powell, Michael W. Mather, Tracey Davey, Steven Lisgo, Nicholas Dawe, Muzlifah Haniffa, Catherine F Hatton, Livia Delpiano, Justin Engelbert, Philip Yates, Chris Ward, Colin D. Bingle, Xin Xu
Publikováno v:
Laryngoscope Investigative Otolaryngology
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 5, Pp 1167-1174 (2021)
Laryngoscope Investigative Otolaryngology, Vol 6, Iss 5, Pp 1167-1174 (2021)
Introduction\ud \ud Otitis media is an umbrella term for middle ear inflammation; ranging from acute infection to chronic mucosal disease. It is a leading cause of antimicrobial therapy prescriptions and surgery in children. Despite this, treatments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8771d94a2c379b0187c290e8bc3bb2
Autor:
Florian Gothe, Jarmila Stremenova Spegarova, Catherine F. Hatton, Helen Griffin, Thomas Sargent, Sally A. Cowley, William James, Anna Roppelt, Anna Shcherbina, Fabian Hauck, Hugh T. Reyburn, Christopher J.A. Duncan, Sophie Hambleton
Publikováno v:
The Journal of allergy and clinical immunology. 150(4)
Background Inflammatory phenomena such as hyperinflammation or hemophagocytic lymphohistiocytosis are a frequent yet paradoxical accompaniment to virus susceptibility in patients with impairment of type I interferon (IFN-I) signaling caused by defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16403a3f5aad639873ed5c5807348c9
https://pubmed.ncbi.nlm.nih.gov/35182547
https://pubmed.ncbi.nlm.nih.gov/35182547
Autor:
Jason Powell, Sandra Murphy, Emily Stephenson, Benjamin J. Thompson, Jonathan M. Scott, Maria Emilia Dueñas, Muzlifah Haniffa, Sophie Hambleton, Chris Ward, Jonathan Coxhead, Gary Reynolds, James P. Garnett, Rafiqul Hussain, Aaron Gardner, Anjam C M Khan, John Simpson, Malcolm Brodlie, Matthias Trost, Tracey Davey, Iram J. Haq, Jarmila Stremenova Spegarova, Lei Huang, Christopher J A Duncan, Sean Carrie, Catherine F Hatton, Bernard Verdon, Florian Gothe, Rachel A. Botting
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to outcome of SARS-CoV-2. Yet little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd82c2156fed1bb54bfe6ba438a81ee3
https://doi.org/10.1101/2021.02.17.431591
https://doi.org/10.1101/2021.02.17.431591