Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Catherine E. Gatza"'
Autor:
Catherine E. Gatza, Jennifer L. Elderbroom, Sun Young Oh, Mark D. Starr, Andrew B. Nixon, Gerard C. Blobe
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 6, Pp 489-500 (2014)
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that are over-expressed in breast cancer, with context dependent effects on breast cancer pathogenesis. The type III TGF-β receptor (TβRIII) mediates BMP signaling. While TβR
Externí odkaz:
https://doaj.org/article/56a079dded554a2dac59ffe1f73a942d
Autor:
Catherine E. Gatza, Alisha. Holtzhausen, Kellye C. Kirkbride, Allyson. Morton, Michael L. Gatza, Michael B. Datto, Gerard C. Blobe
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 8, Pp 758-770 (2011)
The type III TGF-β receptor (TβRIII or betagylcan) is a TGF-β superfamily coreceptor with emerging roles in regulating TGF-β superfamily signaling and cancer progression. Alterations in TGF-β superfamily signaling are common in colon cancer; how
Externí odkaz:
https://doaj.org/article/48ef2d21b6f34b538e3d505460dd02fe
Autor:
Jennifer J. Huang, Mark D. Starr, Gerard C. Blobe, Jian Chen, Catherine E. Gatza, Andrew B. Nixon, Jennifer L. Elderbroom, Tam How
Publikováno v:
Molecular Biology of the Cell
The type III TGF-β receptor (TβRIII) undergoes ectodomain shedding, with surface TβRIII enhancing and soluble TβRIII inhibiting TGF-β signaling. TβRIII mutants with impaired or enhanced shedding are used to demonstrate that the ratio of soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56823125db8378a4541b645b533cf2c
http://europepmc.org/articles/PMC4142606
http://europepmc.org/articles/PMC4142606
Autor:
Gerard C. Blobe, Andrew B. Nixon, Tam How, Mark D. Starr, Catherine E. Gatza, Alison E. Meyer
Publikováno v:
Molecular Biology of the Cell
TβRIII is basolaterally localized in polarized breast epithelial cells. The disruption of TβRIII targeting by mutation of proline 826 results in global loss of cell polarity through enhanced EMT. The mistargeting of TβRIII results in enhanced prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908af44ba4c7605745abddcdfa9d79a7
http://europepmc.org/articles/PMC4116303
http://europepmc.org/articles/PMC4116303
Autor:
Arun Sharma, Catherine E. Gatza, Gerard C. Blobe, Nam Y. Lee, Christelle Golzio, Nicholas Katsanis
Publikováno v:
Molecular Biology of the Cell
Endoglin interacts with PI3K via GIPC to recruit and activate PI3K/Akt at the cell membrane. TGF-β1 attenuates, whereas BMP-9 enhances, endoglin/GIPC-mediated membrane scaffolding of PI3K/Akt to alter endothelial capillary tube stability in vitro, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b793859f5af9a5de23def9650ed95d4e
https://doi.org/10.1091/mbc.e11-12-0993
https://doi.org/10.1091/mbc.e11-12-0993
Publikováno v:
Cellular Signalling. 22:1163-1174
Transforming growth factor beta (TGF-beta) superfamily ligands have important roles in regulating cellular homeostasis, embryonic development, differentiation, proliferation, immune surveillance, angiogenesis, motility, and apoptosis in a cell type a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8647d03fe8c4eb235cabc2a1cedd906
https://doi.org/10.1016/j.cellsig.2010.01.016
https://doi.org/10.1016/j.cellsig.2010.01.016
Autor:
Frances S. Kittrell, Robert K. Dearth, Catherine E. Gatza, Daniel Medina, Lawrence A. Donehower, Adrian V. Lee, Melissa Dumble, David Edwards, Jianming Xu
Publikováno v:
Developmental Biology. 313:130-141
The tumor suppressor p53 is important for inhibiting the development of breast carcinomas. However, little is known about the effects of increased p53 activity on mammary gland development. Therefore, the effect of p53 dosage on mammary gland develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b8d9e8c76ac8ee9ad899cf137a9c7a
https://doi.org/10.1016/j.ydbio.2007.10.004
https://doi.org/10.1016/j.ydbio.2007.10.004
Publikováno v:
Cell Cycle. 6:52-55
The ability of tissues to maintain homeostasis is dependent in part on the function of adult tissue stem cells, which have the capability to self-renew and differentiate into multiple lineages. It has been hypothesized that the ability of stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e8f3ba5230692477f2d6259d2009ce
https://doi.org/10.4161/cc.6.1.3667
https://doi.org/10.4161/cc.6.1.3667
Autor:
Sundaresan Venkatachalam, Lawrence A. Donehower, Stuart D. Tyner, Melissa Dumble, Catherine E. Gatza
Publikováno v:
Annals of the New York Academy of Sciences. 1019:171-177
Cancer suppression is an integral component of longevity in organisms with renewable tissues. A number of genes in the mammalian genome function in cancer prevention, and some of these have been directly implicated in longevity assurance. One such lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c8ae9b7c5f411c057115ce992aaf4f
https://doi.org/10.1196/annals.1297.027
https://doi.org/10.1196/annals.1297.027
The type III TGF-β receptor (TβRIII) is a ubiquitous co-receptor for TGF-β superfamily ligands with roles in suppressing cancer progression, in part through suppressing cell motility. Here we demonstrate that TβRIII promotes epithelial cell adhes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c3d9da47d62c50d5354f520d50f97b
https://europepmc.org/articles/PMC3835656/
https://europepmc.org/articles/PMC3835656/
