Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Catherine E. Bond"'
Autor:
Alexandra M. Kane, Lochlan J. Fennell, Cheng Liu, Jennifer Borowsky, Diane M. McKeone, Catherine E. Bond, Stephen Kazakoff, Ann-Marie Patch, Lambros T. Koufariotis, John Pearson, Nicola Waddell, Barbara A. Leggett, Vicki L.J. Whitehall
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 2, Pp 120-128 (2020)
The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAFV600E and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite insta
Externí odkaz:
https://doaj.org/article/54cf7836ff7a4539bd24d079728bf56e
Autor:
Catherine E. Bond, Cheng Liu, Futoshi Kawamata, Diane M. McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L. Woods, Tamsin R. M. Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J. Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L. Worthley, Barbara A. Leggett, Vicki L. J. Whitehall
Publikováno v:
Epigenetics, Vol 13, Iss 1, Pp 40-48 (2018)
Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human serrated colorectal polyps frequently exhibit both oncogenic BRAF mutation and widespread
Externí odkaz:
https://doaj.org/article/a0eb35f1f5c1498b9b8dd60644c1c526
Publikováno v:
Gastroenterology Research and Practice, Vol 2018 (2018)
The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and the BRAF V600E has been commonly associ
Externí odkaz:
https://doaj.org/article/0921c89e46c942e680bee526d32d18fd
Autor:
Lochlan J Fennell, Gunter Hartel, Diane M McKeone, Catherine E Bond, Alexandra Kane, Barbara A Leggett, Ann-Marie Patch, Vicki LJ Whitehall
BackgroundResearching the murine epigenome in disease models has been hampered by the lack of an appropriate and cost-effective DNA methylation array. Until recently, investigators have been limited to the relatively expensive and analysis intensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785888697d50cbdccb97e80abd13d0e7
https://doi.org/10.1101/2022.03.07.483250
https://doi.org/10.1101/2022.03.07.483250
Autor:
Chang Su, Lochlan J Fennell, Catherine E Bond, Alexandra M Kane, Genevieve Kerr, Thierry Jardé, Diana Micati, Rebekah M Engel, Wing Hei Chan, Sara Hlavca, Stuart Archer, Paul J McMurrick, Heinz Hammerlindl, Fayth Lim, Basit Salik, Diane M McKeone, Gunter Hartel, Jennifer Borowsky, Rahul Ladwa, Barbara A Leggett, Helmut Schaider, Helen E Abud, Glen M Boyle, Matthew E Burge, Vicki LJ Whitehall
PurposeRegorafenib is a multi-kinase inhibitor approved for refractory metastatic colorectal cancer. Previous studies have suggested that combining kinase inhibitors with aspirin may improve patient outcomes. We aimed to determine the effects of aspi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08e038486c64e20f79f3d5071b95732
https://doi.org/10.1101/2022.02.11.480021
https://doi.org/10.1101/2022.02.11.480021
Publikováno v:
Cancers. 15:805
Colorectal cancer is an important cause of morbidity and mortality worldwide. The current treatment landscape includes chemotherapy, targeted therapy, immunotherapy, radiotherapy, and surgery. A key challenge to improving patient outcomes is the sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4cc7c2a829d8d6ece30c2c4ffc13420
https://doi.org/10.3390/cancers15030805
https://doi.org/10.3390/cancers15030805
Autor:
Lochlan J. Fennell, Gunter Hartel, Diane M. McKeone, Catherine E. Bond, Alexandra Kane, Barbara A. Leggett, Ann-Marie Patch, Vicki L.J. Whitehall
Publikováno v:
Cell Reports Methods. 2:100323
Researching the murine epigenome in disease models has been hampered by the lack of appropriate and cost-effective DNA methylation arrays. Here we perform a comprehensive, comparative analysis between the Mouse Methylation BeadChip (MMB) and reduced-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6845d804a44673b38c294fb13988305d
https://doi.org/10.1016/j.crmeth.2022.100323
https://doi.org/10.1016/j.crmeth.2022.100323
Autor:
Catherine E Bond, Aarti Umapathy, Ron L Buttenshaw, Leesa Wockner, Barbara A Leggett, Vicki L J Whitehall
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47483 (2012)
The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of these BRAF mutant cancers demonstrate frequent frameshift mutations termed microsatellite instability (MSI), but are diploid and chromosomally stable. BRAF wild
Externí odkaz:
https://doaj.org/article/a88d501026f3497f8b3cd992c9c72c02
Publikováno v:
Gastroenterology Research and Practice
The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and the BRAF V600E has been commonly associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48884f1330cf0499d7003a78c2136928
https://pubmed.ncbi.nlm.nih.gov/30598662
https://pubmed.ncbi.nlm.nih.gov/30598662
Autor:
Catherine E Bond, Derek J Nancarrow, Leesa F Wockner, Leanne Wallace, Grant W Montgomery, Barbara A Leggett, Vicki L J Whitehall
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91739 (2014)
The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS) confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis. BRAF wild type cancers are typica
Externí odkaz:
https://doaj.org/article/815828ac81784e45b8f25feec3591261