Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Catherine Dubertret"'
Autor:
Kostas Antonakis, Catherine Dubertret, Daniel Scherman, Bruno Pitard, Joseph W. Turek, Gabrielle Jaslin
Publikováno v:
The Journal of Gene Medicine. 2:32-40
Background Cationic lipids are the most widely used nonviral vectors for gene delivery. Upon complexation to DNA, they offer a nonimmunogenic alternative to viral gene transfer. Unfortunately, their in vivo application has been limited due to a serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22e03fa34a01622190ab4ebca814a89
https://doi.org/10.1002/(sici)1521-2254(200001/02)2:1<32::aid-jgm78>3.0.co
https://doi.org/10.1002/(sici)1521-2254(200001/02)2:1<32::aid-jgm78>3.0.co
Autor:
D Dang, S Somarriba, Fabienne Soubrier, Gabrielle Jaslin, C Le Caer, Joel Crouzet, Catherine Dubertret, Jean-François Mayaux, Béatrice Cameron, Daniel Scherman, B Manse, G Jung, J M Mouvault
Publikováno v:
Gene Therapy. 6:1482-1488
A totally redesigned host/vector system with improved properties in terms of safety has been developed. The pCOR plasmids are narrow-host range plasmid vectors for nonviral gene therapy. These plasmids contain a conditional origin of replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe3f5aed0b8524481ad848a0901fce7
https://doi.org/10.1038/sj.gt.3300968
https://doi.org/10.1038/sj.gt.3300968
Autor:
Catherine Dubertret, Pierre Wils, Daniel Scherman, Ravi Rangara, Joel Crouzet, Gerardo Byk, Bertrand Schwartz, Virginie Escriou, Marc Frederic, Bruno Pitard, Gabrielle Jaslin
Publikováno v:
Journal of Medicinal Chemistry. 41:224-235
We have designed and synthesized original cationic lipids for gene delivery. A synthetic method on solid support allowed easy access to unsymmetrically monofunctionalized polyamine building blocks of variable geometries. These polyamine building bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f253809e003e8d064bece41213073101
https://doi.org/10.1021/jm9704964
https://doi.org/10.1021/jm9704964
Autor:
Gerardo Byk, Tsiala Boukhnikachvili, Christian Herviou, Jean-François Mayaux, Anne-Marie Lachagès, Bruno Pitard, Daniel Scherman, Marc Airiau, Joel Crouzet, Catherine Dubertret, Olivier Aguerre
Publikováno v:
Proceedings of the National Academy of Sciences. 94:14412-14417
Gene therapy is based on the vectorization of genes to target cells and their subsequent expression. Cationic amphiphile-mediated delivery of plasmid DNA is the nonviral gene transfer method most often used. We examined the supramolecular structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42c736486c30d359834a7a1343516b89
https://doi.org/10.1073/pnas.94.26.14412
https://doi.org/10.1073/pnas.94.26.14412
Autor:
Gerardo Byk, Catherine Dubertret, Bertrand Schwartz, Marc Frederic, Gabrielle Jaslin, Ravi Rangara, Daniel Scherman
Publikováno v:
Letters in Peptide Science. 4:263-267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98a898dc1ded2fd6780a640ade650c45
https://doi.org/10.1007/bf02442887
https://doi.org/10.1007/bf02442887
Autor:
Catherine Dubertret, Daniel Scherman, Ravi Rangara, Gerardo Byk, Bertrand Schwartz, Marc Frederic, Gabrielle Jaslin
Publikováno v:
Letters in Peptide Science. 4:263-267
We have synthesized novel cationiclipids for gene delivery bearing an ester bond betweenthe lipid moiety and the polyamine head. We have foundthat an intramolecular rearrangement occurs duringpurification of one of the products. The rearrangementled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::925aef8fca2f65c01540ba47aa61e36b
https://doi.org/10.1023/a:1008872115688
https://doi.org/10.1023/a:1008872115688
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::939a9d7bbb6befe70e6db82f8b111676
https://doi.org/10.1002/chin.199843217
https://doi.org/10.1002/chin.199843217
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1393-1395
Lipidic glycosides with amino alkyl pendent groups were synthesized and evaluated for in vitro DNA transfection activity. The first representative of this new class of cationic lipids showed good gene delivery and low toxicity to HeLa and 3T3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2bf61328e3e33779d7a54c5305e3f2
https://doi.org/10.1016/s0960-894x(00)00251-1
https://doi.org/10.1016/s0960-894x(00)00251-1
Autor:
Gerardo Byk, Bertrand Schwartz, Daniel Scherman, Catherine Dubertret, Marc Frederic, Gabrielle Jaslin
Publikováno v:
American Peptide Symposia ISBN: 0792351606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8b939fa4906b4c58acdbb227d8cfd5
https://doi.org/10.1007/0-306-46862-x_359
https://doi.org/10.1007/0-306-46862-x_359
Autor:
Jeff S. Nelson, Claude Hélène, Michael R. H. White, David G. Spiller, Daniel Scherman, Carine Giovannangeli, Catherine Dubertret, Marcella Faria
Publikováno v:
Nature biotechnology. 19(1)
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the synthesis of the encoded protein. Uniformly modified oligonucleotides containing N3'-P5' phosphoramidate linkages exhibit (NP) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e213aa0d4463214930eb18cf8416c8d
https://pubmed.ncbi.nlm.nih.gov/11135542
https://pubmed.ncbi.nlm.nih.gov/11135542