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pro vyhledávání: '"Catherine D. Prescott"'
Autor:
Neil D. Pearson, Catherine D. Prescott
Publikováno v:
Chemistry & Biology. 4(6):409-414
Historically, the pharmaceutical industry has focused on proteins, rather than nucleic acids, as drug targets. But recent advances in the fields of RNA synthesis, structure determination and therapeutic target identification make the systematic explo
Publikováno v:
Nucleic Acids Research. 20:1567-1571
The in vivo expression of mutations constructed within helix 34 of 16S rRNA has been examined together with a nonsense tRNA suppressor for their action at stop codons. The data revealed two novel results: in contrast to previous findings, some of the
Autor:
Catherine D. Prescott, H U Göringer
Publikováno v:
Nucleic Acids Research. 18:5381-5386
A single base change in 16S rRNA (C726 to G) has previously been shown to have a dramatic effect on protein synthesis in E. coli (1). This paper more specifically details the effects of the mutation on mRNA binding and translation-termination. The in
Publikováno v:
Nucleic Acids Research. 19:5281-5283
It was established some time ago that the deletion of base C1054 in E. coli 16S rRNA specifically affects UGA-dependent termination of translation. Based on this observation, a model for the termination event was proposed in which the UGA nonsense co
Autor:
Joyce Mao, Ganesh M. Sathe, Kathleen M. Herold, Catherine D. Prescott, Richard R. Gontarek, Jane Tsai, Alfred M. Del Vecchio, Lester L. Gutshall
Publikováno v:
Nucleic acids research. 27(6)
Like other members of the Flaviviridae family, the 3' non-translated region (NTR) of the hepatitis C virus (HCV) is believed to function in the initiation and regulation of viral RNA replication by interacting with components of the viral replicase c
Publikováno v:
The Journal of biological chemistry. 273(17)
Elongation factor-3 (EF-3) is an essential fungal-specific translation factor which exhibits a strong ribosome-dependent ATPase activity and has sequence homologies that may predict domains critical for its role in protein synthesis, including a doma
Autor:
Sabine Guth, Catherine D. Prescott, Hu Li, Lisa A. Hegg, Michael J. Gress, Richard R. Gontarek, Donna Rispoli, Victoria Emerick, Kelvin Nurse, George Thom, Therese Sterner
Publisher Summary The functional importance of ribonucleic acid (RNA); participating in almost all macromolecular processes, is well established. RNA motifs regulate RNA processing, messenger RNA (mRNA) translation, stability and localization. The mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b310d43ab49e9dd8ec695f21af3394c7
https://doi.org/10.1016/b978-012233210-4/50007-4
https://doi.org/10.1016/b978-012233210-4/50007-4
Autor:
Ian Jeffrey, David Justin Charles Knowles, George Thom, Catherine D. Prescott, Barbara-Ann Howard, Dave Colthurst
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 73(11-12)
RNA molecules perform a variety of important and diverse functions and, therefore, an understanding of their structure and interaction with proteins and ligands is essential. Large RNA molecules (for example, the ribosomal RNAs) are complex and hence
Publikováno v:
Biochemical Society Transactions. 16:45-46
The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presenta