Sympathetic Nervous Regulation of Calcium and Action Potential Alternans in the Intact Heart

Autor: James Winter, Martin J. Bishop, Catherine D. E. Wilder, Christopher O'Shea, Davor Pavlovic, Michael J. Shattock

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Rationale: Arrhythmogenic cardiac alternans are thought to be an important determinant for the initiation of ventricular fibrillation. There is limited information on the effects of sympathetic nerve stimulation (SNS) on alternans in the intact heart

Externí odkaz: https://doaj.org/article/84c1a053dcf644699e8d8b5546ba4fab

Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1and β2agonism in the rat heartin vitro

Autor: Catherine D. E. Wilder, Ellice Caldwell-Dunn, Michael J. Curtis, Antonella Ranieri, Tutku Dursun, Hannah R. Lewis, Paul Gyimah, Nikoleta Pavlaki

Publikováno v: British Journal of Pharmacology. 175:1669-1690

BACKGROUND & PURPOSE: Antiarrhythmic β-blockers are used in patients at risk of myocardial ischaemia, but the survival benefit and mechanisms are unclear. We hypothesised that β-blockers do not prevent ventricular fibrillation (VF), but instead inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d583c478ffe7ee4872f65e8b276af605
https://doi.org/10.1111/bph.14176

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

Autor: Klaus-Dieter Schlüter, Soni Deshwal, Hans Erik Bøtker, Michael Rahbek-Schmidt, Derek J. Hausenloy, Zoltán Giricz, Péter Ferdinandy, Moises Di Sante, David Garcia-Dorado, Fabio Di Lisa, Kerstin Boengler, Nina Kaludercic, Pasquale Pagliaro, Marisol Ruiz-Meana, Andreas Skyschally, Sean M. Davidson, Borja Ibanez, Gerd Heusch, Michel Ovize, Ioanna Andreadou, Efstathios K. Iliodromitis, Catherine D. E. Wilder, Panagiotis Efentakis, Salvatore Antonucci, Markus Neuhäuser, Petra Kleinbongard, Rainer Schulz, Saveria Femminò, Derek M. Yellon, Yvan Devaux

Publikováno v: Basic Research in Cardiology
Bøtker, H E, Hausenloy, D, Andreadou, I, Antonucci, S, Boengler, K, Davidson, S M, Deshwal, S, Devaux, Y, Di Lisa, F, Di Sante, M, Efentakis, P, Femminò, S, García-Dorado, D, Giricz, Z, Ibanez, B, Iliodromitis, E, Kaludercic, N, Kleinbongard, P, Neuhäuser, M, Ovize, M, Pagliaro, P, Rahbek-Schmidt, M, Ruiz-Meana, M, Schlüter, K-D, Schulz, R, Skyschally, A, Wilder, C, Yellon, D M, Ferdinandy, P & Heusch, G 2018, ' Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection ', Basic Research in Cardiology. Supplement, vol. 113, no. 5, pp. 39 . https://doi.org/10.1007/s00395-018-0696-8
Basic Research in Cardiology, Springer Verlag, 2018, 113 (5), pp.73
Repisalud
Instituto de Salud Carlos III (ISCIII)

The potential for ischemic preconditioning to reduce infarct size was first recognized more than 30 years ago. Despite extension of the concept to ischemic postconditioning and remote ischemic conditioning and literally thousands of experimental stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a8943c1ccaa7e021aed8c824c38722
https://hal.archives-ouvertes.fr/hal-02003550

Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β

Autor: Catherine D E, Wilder, Nikoleta, Pavlaki, Tutku, Dursun, Paul, Gyimah, Ellice, Caldwell-Dunn, Antonella, Ranieri, Hannah R, Lewis, Michael J, Curtis

Publikováno v: British journal of pharmacology. 175(10)

BACKGROUND AND PURPOSE: Antiarrhythmic β‐blockers are used in patients at risk of myocardial ischaemia, but the survival benefit and mechanisms are unclear. We hypothesized that β‐blockers do not prevent ventricular fibrillation (VF) but instea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4132b12bda6065faed6cbf6556022064
https://pubmed.ncbi.nlm.nih.gov/29473948

Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation

Autor: Catherine D E, Wilder, Radwa, Masoud, Duygu, Yazar, Brett A, O'Brien, Thomas R, Eykyn, Michael J, Curtis

Publikováno v: British journal of pharmacology. 173(1)

In drug research using the rat Langendorff heart preparation, it is possible to study left ventricular (LV) contractility using an intraventricular balloon (IVB), and arrhythmogenesis during coronary ligation-induced regional ischaemia. Assessing bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a6a613aa63871753128a20ca3624fc0
https://pubmed.ncbi.nlm.nih.gov/26377788