Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Catherine Coffinier"'
Publikováno v:
Journal of Biological Chemistry. 287:16103-16110
The nuclear lamina is composed mainly of lamins A and C (A-type lamins) and lamins B1 and B2 (B-type lamins). Dogma has held that lamins B1 and B2 play unique and essential roles in the nucleus of every eukaryotic cell. Recent studies have raised dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4df17509442ef22e97af51a4453bf3
https://doi.org/10.1074/jbc.r112.354407
https://doi.org/10.1074/jbc.r112.354407
Publikováno v:
Nucleus. 2:562-569
The B-type lamins are widely assumed to be essential for mammalian cells. In part, this assumption is based on a highly cited study that found that RNAi-mediated knockdown of lamin B1 or lamin B2 in HeLa cells arrested cell growth and led to apoptosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ad10c189073a7b1fbb69507d6e236e
https://doi.org/10.4161/nucl.2.6.18085
https://doi.org/10.4161/nucl.2.6.18085
Autor:
Brandon S.J. Davies, Richard H. Barnes, Stephen G. Young, Catherine Coffinier, Hea-Jin Jung, Loren G. Fong, Shao H. Yang
Publikováno v:
Nucleus. 2:4-9
Lmna yields two major protein products in somatic cells, lamin C and prelamin A. Mature lamin A is produced from prelamin A by four posttranslational processing steps-farnesylation of a carboxyl-terminal cysteine, release of the last three amino acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893682a88e837be468f86db2cd1378ca
https://doi.org/10.4161/nucl.13723
https://doi.org/10.4161/nucl.13723
Autor:
Chika Nobumori, Emily Farber, Júlia Tóth, Catherine Coffinier, Sandy Y. Chang, Loren G. Fong, Stephen G. Young, Yiping Tu
Publikováno v:
Proceedings of the National Academy of Sciences. 107:5076-5081
Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nucleus. Defects in lamins A and C cause an array of human diseases, including muscular dystrophy, lipodystrophy, and progeria, but no diseases have been linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8391a2c56a18188ce0984b80f4f3974
https://doi.org/10.1073/pnas.0908790107
https://doi.org/10.1073/pnas.0908790107
Autor:
Christine Choi, Emily Farber, C. Frank Bennett, Catherine Coffinier, Roger Lee, Brandon S.J. Davies, Liya Yin, H. Peter Spielmann, Timothy A. Vickers, Stephen G. Young, Loren G. Fong, Douglas A. Andres, Ui Jeong Yun, Yan Hu, Shao H. Yang
Publikováno v:
Human molecular genetics, vol 18, iss 13
Human Molecular Genetics
Human Molecular Genetics
Hutchinson-Gilford progeria syndrome (HGPS) is caused by point mutations that increase utilization of an alternate splice donor site in exon 11 of LMNA (the gene encoding lamin C and prelamin A). The alternate splicing reduces transcripts for wild-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c22884431a4f5e44721178b25a5d5b
https://doi.org/10.1093/hmg/ddp184
https://doi.org/10.1093/hmg/ddp184
Autor:
Loren G. Fong, Sarah E. Hudon, Stephen G. Young, Christine A. Hrycyna, Emily Farber, Catherine Coffinier, Sandy Y. Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 104:13432-13437
HIV protease inhibitors (HIV-PIs) target the HIV aspartyl protease, which cleaves the HIV gag-pol polyprotein into shorter proteins required for the production of new virions. HIV-PIs are a cornerstone of treatment for HIV but have been associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d0c1f441178c66307a22bcb57b4e66
https://doi.org/10.1073/pnas.0704212104
https://doi.org/10.1073/pnas.0704212104
Autor:
Margarita Meta, David Frost, Shao H. Yang, Joy Bauch, Sharmila Majumdar, Catherine Coffinier, Loren G. Fong, Xin Qiao, Martin O. Bergo, Stephen G. Young
Publikováno v:
Journal of Clinical Investigation. 116:2115-2121
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated prelamin A, called progerin, which is farnesylated at its carboxyl terminus. Progerin is targeted to the nuclear envelope and causes misshapen nuclei. Protein farn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddddf759de543b8d33c20e7d538314f
https://doi.org/10.1172/jci28968
https://doi.org/10.1172/jci28968
Autor:
J. Barra, Charles Babinet, Günther Schütz, François Tronche, Marco Pontoglio, Moshe Yaniv, Catherine Coffinier, Laurence Fiette, Lionel Gresh
Publikováno v:
Development. 129:1829-1838
The inactivation of the Hnf1β gene identified an essential role in epithelial differentiation of the visceral endoderm and resulted in early embryonic death. In the present study, we have specifically inactivated this gene in hepatocytes and bile du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce0eb5199ea9bdead114deef41e61a2
https://doi.org/10.1242/dev.129.8.1829
https://doi.org/10.1242/dev.129.8.1829
Autor:
Chika Nobumori, Loren G. Fong, Stephen G. Young, Daniel Wu, Hea-Jin Jung, Yiping Tu, Yuko Yoshinaga, John M. Lee, Catherine Coffinier, Pieter J. de Jong, Angelica Tatar
Publikováno v:
Molecular biology of the cell, vol 25, iss 10
Molecular Biology of the Cell
Molecular Biology of the Cell
To assess the redundancy of lamins B1 and B2, knock-in lines were created that produce lamin B2 from the Lmnb1 locus and lamin B1 from the Lmnb2 locus. Both lines developed severe neurodevelopmental abnormalities, indicating that the abnormalities el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d217271824ca880122117473d5e277e5
https://escholarship.org/uc/item/4xs335c7
https://escholarship.org/uc/item/4xs335c7
Publikováno v:
Mechanisms of Development. 100:119-122
Cysteine-rich repeats (CRs) of the type described in Chordin constitute conserved domains present in an expanding family of secreted molecules. These motifs were shown to mediate directly the antagonism of BMP signaling by Chordin and play a major ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5699ff75f9cfabbcae4552522992c6
https://doi.org/10.1016/s0925-4773(00)00507-4
https://doi.org/10.1016/s0925-4773(00)00507-4