Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Catherine C. Robertson"'
Autor:
Catherine C. Robertson, Ruth M. Elgamal, Belle A. Henry-Kanarek, Peter Arvan, Shuibing Chen, Sangeeta Dhawan, Decio L. Eizirik, John S. Kaddis, Golnaz Vahedi, Stephen C.J. Parker, Kyle J. Gaulton, Scott A. Soleimanpour
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101973- (2024)
Background: Type 1 diabetes (T1D) is a complex multi-system disease which arises from both environmental and genetic factors, resulting in the destruction of insulin-producing pancreatic beta cells. Over the past two decades, human genetic studies ha
Externí odkaz:
https://doaj.org/article/2fd0a447e207481d8751377f9c298a7a
Autor:
Tom G. Richardson, Daniel J. M. Crouch, Grace M. Power, Fernanda Morales-Berstein, Emma Hazelwood, Si Fang, Yoonsu Cho, Jamie R. J. Inshaw, Catherine C. Robertson, Carlo Sidore, Francesco Cucca, Steven S. Rich, John A. Todd, George Davey Smith
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The rise in type 1 diabetes is thought to be related to increased childhood obesity, but this relationship is not well understood. In this study, the authors utilize Mendelian randomization to separate the direct and indirect effects of childhood bod
Externí odkaz:
https://doaj.org/article/55ec50450cf64eeead5afd4828008092
Autor:
Jamie Inshaw, Fabio Busonero, Eleonora Porcu, Maristella Pitzalis, Eleonora Cocco, Margherita Chessa, Helen M. Colhoun, Annalisa Loizedda, Marco Masala, Gonçalo R. Abecasis, Maria Giovanna Marrosu, Lidia Leoni, Carlo Sidore, Mario Lovicu, Annapaola Frongia, David Schlessinger, Sandra Lai, Nicolò Curreli, Andrea Maschio, Lenuta Balaci, Liana Ap Ferreli, Fausto Pier'Angelo Poddie, Francesca Virdis, Suna Onengut-Gumuscu, John A. Todd, Michele Marongiu, Valeria Orrù, Maria Rossella Ricciardi, Magdalena Zoledziewska, Antonello Pani, Mariano Dei, Stephen S. Rich, Francesca Deidda, Jessica Frau, Mauro Pala, Nazario Olla, Paola Ferrigno, Edoardo Fiorillo, Gabriella Sole, Alessandro P Delitala, Valentina Serra, Francesco Loi, Stuart J. McGurnaghan, Maristella Steri, Maria Grazia Pilia, Antonella Mulas, Matteo Floris, Francesco Cucca, Luisa Mereu, Catherine C. Robertson
Publikováno v:
Mult Scler
Background: Defective alleles within the PRF1 gene, encoding the pore-forming protein perforin, in combination with environmental factors, cause familial type 2 hemophagocytic lymphohistiocytosis (FHL2), a rare, severe autosomal recessive childhood d
Autor:
Ezio Bonifacio, Andreas Beyerlein, Christiane Winker, Andrea K. Steck, Marian Rewers, Suna Onengut-Gumuscu, Markus Hippich, Jeffrey P. Krischer, Stephen S. Rich, Anette-G. Ziegler, Jorma Toppari, Kendra Vehik, Åke Lernmark, Jin-Xiong She, Jan Knoop, William Hagopian, Beena Akolkar, Catherine C. Robertson
Publikováno v:
Diabetes
Diabetes 68, 847-857 (2019)
Diabetes 68, 847-857 (2019)
The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-ris
Autor:
Berstein Fm, Carlo Sidore, Stephen S. Rich, Si Fang, Grace M. Power, Catherine C. Robertson, Hazelwood E, Francesco Cucca, Crouch Djm., John A. Todd, Inshaw Jrj., Tom G. Richardson, George Davey Smith, Yoonsu Cho
BackgroundThe rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D). However, robust causal evidence supporting this claim has been extremely challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409a5e2c06ca464803a76745e7ba55a4
https://doi.org/10.1101/2021.04.19.21255222
https://doi.org/10.1101/2021.04.19.21255222
Autor:
Tom G, Richardson, Daniel J M, Crouch, Grace M, Power, Fernanda, Morales-Berstein, Emma, Hazelwood, Si, Fang, Yoonsu, Cho, Jamie R J, Inshaw, Catherine C, Robertson, Carlo, Sidore, Francesco, Cucca, Steven S, Rich, John A, Todd, George, Davey Smith
Publikováno v:
Nature communications. 13(1)
The rising prevalence of childhood obesity has been postulated as an explanation for the increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use Mendelian randomization (MR) to provide evidence that childhood body s
Autor:
Flemming Pociot, Wei Chen, Carlo Sidore, Patrick Concannon, Jie Zhang, Crouch Djm., John A. Todd, Stephen S. Rich, Inshaw, Suna Onengut-Gumuscu, Antony J. Cutler, Francesco Cucca, Catherine C. Robertson
For polygenic traits, associations with genetic variants can be detected over many chromosome regions, owing to the availability oflarge sample sizes. Most variants, however, have small effects on disease risk and, therefore, unravelling the causal v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8f84d31c6926143741ece46fdd4c839
https://doi.org/10.1101/2021.02.05.429962
https://doi.org/10.1101/2021.02.05.429962
Autor:
Patrick Concannon, Amy S. Shah, Linda S. Wicker, Suna Onengut-Gumuscu, Dana Dabelea, Chen W-M., Robert P. Kimberly, Jasmin Divers, David B. Dunger, Peter K. Gregersen, Jeffrey C. Edberg, Stephen S. Rich, Huan Yang, Santica M. Marcovina, Antony J. Cutler, S L Bridges, Marian Rewers, Carla J. Greenbaum, Flemming Pociot, Jorge R. Oksenberg, Jean M. Lawrence, Inshaw Jrj., D F Santa Cruz, Andrea K. Steck, Panagiotis Deloukas, Mark A. Atkinson, John A. Todd, Emily Farber, Crouch Djm., Jane H. Buckner, Catherine C. Robertson
Publikováno v:
Robertson, C C & Type 1 Diabetes Genetics Consortium 2021, ' Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes ', Nature Genetics, vol. 53, no. 7, pp. 962-971 . https://doi.org/10.1101/2020.06.19.158071, https://doi.org/10.1038/s41588-021-00880-5
Nature genetics
Nature genetics
We report the largest and most ancestrally diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 152 regions associated to false discovery rate < 0.01, including 36 regions associated to genome-wide significance for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3f66533a4cf7a2a983554fd2421f8
https://curis.ku.dk/ws/files/284012839/2020.06.19.158071v1.full.pdf
https://curis.ku.dk/ws/files/284012839/2020.06.19.158071v1.full.pdf
Autor:
Suzanne B.R. Jacobs, Stephen S. Rich, Catherine C. Robertson, Joanne B. Cole, Laura N. Brenner, Ling Chen, Jose C. Florez, Josep M. Mercader
Publikováno v:
Journal of the Endocrine Society. 4
Glucocorticoids have multiple therapeutic benefits and are used both for immunosuppression and treatment purposes. Notwithstanding their benefits, glucocorticoid use often leads to hyperglycemia. Owing to the pathophysiologic overlap in glucocorticoi
Autor:
Laura N, Brenner, Josep M, Mercader, Catherine C, Robertson, Joanne, Cole, Ling, Chen, Suzanne B R, Jacobs, Stephen S, Rich, Jose C, Florez
Publikováno v:
Journal of the Endocrine Society
Glucocorticoids have multiple therapeutic benefits and are used both for immunosuppression and treatment purposes. Notwithstanding their benefits, glucocorticoid use often leads to hyperglycemia. Owing to the pathophysiologic overlap in glucocorticoi