Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Catherine C Y, Chang"'
Autor:
Junghoon Lee, Adrianna L. De La Torre, Felix L. Rawlinson, Dylan B. Ness, Lionel D. Lewis, William F. Hickey, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9151 (2024)
Cholesterol homeostasis is pivotal for cellular function. Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), also abbreviated as SOAT1, is an enzyme responsible for catalyzing the storage of excess cholesterol to cholesteryl esters. ACAT1 is an e
Externí odkaz:
https://doaj.org/article/0cdf9d54a6cb449a8a13d8b0b47dd0ae
Autor:
Adrianna L. De La Torre, Thao N. Huynh, Catherine C. Y. Chang, Darcy B. Pooler, Dylan B. Ness, Lionel D. Lewis, Sanjana Pannem, Yichen Feng, Kimberley S. Samkoe, William F. Hickey, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11013 (2023)
Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs biosynthesis is catalyzed by the enzymes acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), with ACAT1 being the primary isoenzyme in most cell
Externí odkaz:
https://doaj.org/article/68bc0686d0ab44e1a0995babc0169b8d
Autor:
Ta Yuan Chang, Catherine C. Y. Chang, Taylor C. Harned, Adrianna L. De La Torre, Junghoon Lee, Thao N. Huynh, James G. Gow
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 1, Iss 3, Pp 173-184 (2021)
Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1), also named as sterol O-acyltran
Externí odkaz:
https://doaj.org/article/a718787065e249078cafd7c261450165
Autor:
Taylor C. Harned, Radu V. Stan, Ze Cao, Rajarshi Chakrabarti, Henry N. Higgs, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5525 (2023)
Cholesterol is a key component of all mammalian cell membranes. Disruptions in cholesterol metabolism have been observed in the context of various diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). The genetic and pha
Externí odkaz:
https://doaj.org/article/5caa6aa440cf4cbe8ec2bc52f2f180ce
Autor:
Haibo Li, Thao N. Huynh, Michael Tran Duong, James G. Gow, Catherine C. Y. Chang, Ta Yuan Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5616 (2023)
Cholesterol is stored as cholesteryl esters by the enzymes acyl-CoA:cholesterol acyltransferases/sterol O:acyltransferases (ACATs/SOATs). ACAT1 blockade (A1B) ameliorates the pro-inflammatory responses of macrophages to lipopolysaccharides (LPS) and
Externí odkaz:
https://doaj.org/article/80a218ca3938496ea99e8c8315841209
Autor:
Chengcheng Guan, Yange Niu, Si-Cong Chen, Yunlu Kang, Jing-Xiang Wu, Koji Nishi, Catherine C. Y. Chang, Ta-Yuan Chang, Tuoping Luo, Lei Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the
Externí odkaz:
https://doaj.org/article/358be672ffd24c55bc5303397e78ae42
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Vascular contributions to cognitive impairment and dementia (VCID) are a common cause of cognitive decline, yet limited therapies exist. This cerebrovascular disease results in neurodegeneration via acute, chronic, local, and systemic mechanisms. The
Externí odkaz:
https://doaj.org/article/954f6054b832436ea668c88d57254c44
Autor:
Chang, Adrianna L. De La Torre, Thao N. Huynh, Catherine C. Y. Chang, Darcy B. Pooler, Dylan B. Ness, Lionel D. Lewis, Sanjana Pannem, Yichen Feng, Kimberley S. Samkoe, William F. Hickey, Ta Yuan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11013
Cholesterol is essential for cellular function and is stored as cholesteryl esters (CEs). CEs biosynthesis is catalyzed by the enzymes acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), with ACAT1 being the primary isoenzyme in most cell
Autor:
Maximillian A. Rogers, Catherine C. Y. Chang, Robert A. Maue, Elaina M. Melton, Andrew A. Peden, William S. Garver, Junghoon Lee, Peter Schroen, Mitchell Huang, Ta-Yuan Chang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Niemann-Pick type C disease (NPCD) is an incurable genetic neurological disorder. Cells with NPC mutations fail to export cholesterol from endosomal organelle to multiple other organelles. ACAT1 is an enzyme that converts cholesterol to
Publikováno v:
Arch Biochem Biophys
To conduct biochemical studies in vitro, membrane proteins (MPs) must be solubilized with detergents. While detergents are great tools, they can also inhibit the biological activity and/or perturb oligomerization of individual MPs. Nanodisc scaffold