Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Catherine C Kaczorowski"'
Autor:
Ann E Wells, John J Wilson, Sarah E Heuer, John D Sears, Jian Wei, Raghav Pandey, Mauro W Costa, Catherine C Kaczorowski, Derry C Roopenian, Chih-Hao Chang, Gregory W Carter
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299595 (2024)
ObjectiveGlycolytic inhibition via 2-deoxy-D-glucose (2DG) has potential therapeutic benefits for a range of diseases, including cancer, epilepsy, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA), and COVID-19, but the systemic effec
Externí odkaz:
https://doaj.org/article/22ce3f406d0c4edab2420289fe6e8a30
Autor:
Alex G Nackenoff, Timothy J Hohman, Sarah M Neuner, Carolyn S Akers, Nicole C Weitzel, Alena Shostak, Shawn M Ferguson, Bret Mobley, David A Bennett, Julie A Schneider, Angela L Jefferson, Catherine C Kaczorowski, Matthew S Schrag
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009406 (2021)
Phospholipase D3 (PLD3) is a protein of unclear function that structurally resembles other members of the phospholipase D superfamily. A coding variant in this gene confers increased risk for the development of Alzheimer's disease (AD), although the
Externí odkaz:
https://doaj.org/article/5332a5a2c04747fa938b639208224775
Autor:
Cheyenne D. Hurst, Amy R. Dunn, Eric B. Dammer, Duc M. Duong, Sarah M. Shapley, Nicholas T. Seyfried, Catherine C. Kaczorowski, Erik C. B. Johnson
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
There is an urgent need to improve the translational validity of Alzheimer's disease (AD) mouse models. Introducing genetic background diversity in AD mouse models has been proposed as a way to increase validity and enable the discovery of previously
Externí odkaz:
https://doaj.org/article/b86d50095fd043b3b69d53d76638f43a
Autor:
Lindsay A. Welikovitch, Simon Dujardin, Amy R. Dunn, Analiese R. Fernandes, Anita Khasnavis, Lori B. Chibnik, Catherine C. Kaczorowski, Bradley T. Hyman
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105983- (2023)
Summary: The speed and scope of cognitive deterioration in Alzheimer's disease is highly associated with the advancement of tau neurofibrillary lesions across brain networks. We tested whether the rate of tau propagation is a heritable disease trait
Externí odkaz:
https://doaj.org/article/8b321675abc14004a7beb47a24a7e94f
Autor:
Thomas J. Murdy, Amy R. Dunn, Surjeet Singh, Maria A. Telpoukhovskaia, Shanrong Zhang, Jacqueline K. White, Itamar Kahn, Marcelo Febo, Catherine C. Kaczorowski
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2023)
In human Alzheimer’s disease (AD) patients and AD mouse models, both differential pre-disease brain features and differential disease-associated memory decline are observed, suggesting that certain neurological features may protect against AD-relat
Externí odkaz:
https://doaj.org/article/1a0cee522fcf481995885967879c3090
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
Autor:
Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forth
Externí odkaz:
https://doaj.org/article/36f44c766a3f4b158589d4ac6f731c19
Autor:
Amy R. Dunn, Niran Hadad, Sarah M. Neuner, Ji-Gang Zhang, Vivek M. Philip, Logan Dumitrescu, Timothy J. Hohman, Jeremy H. Herskowitz, Kristen M. S. O’Connell, Catherine C. Kaczorowski
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Developing strategies to maintain cognitive health is critical to quality of life during aging. The basis of healthy cognitive aging is poorly understood; thus, it is difficult to predict who will have normal cognition later in life. Individuals may
Externí odkaz:
https://doaj.org/article/55c45b3c6f334db690a33914c1daf442
Autor:
Megan K. Mulligan, Timothy Abreo, Sarah M. Neuner, Cory Parks, Christine E. Watkins, M. Trevor Houseal, Thomas M. Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine C. Kaczorowski, Camron D. Bryant, Gregg E. Homanics, Robert W. Williams
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and p
Externí odkaz:
https://doaj.org/article/6a8d1268bcf34cf8a5aabfe4fc41124e
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Across the population, individuals exhibit a wide variation of susceptibility or resilience to developing Alzheimer’s disease (AD). Identifying specific factors that promote resilience would provide insight into disease mechanisms and nominate pote
Externí odkaz:
https://doaj.org/article/d710ff394de748c19ea19e829ba10e9c
Autor:
Jaclyn M, Eissman, Logan, Dumitrescu, Emily R, Mahoney, Alexandra N, Smith, Shubhabrata, Mukherjee, Michael L, Lee, Phoebe, Scollard, Seo Eun, Choi, William S, Bush, Corinne D, Engelman, Qiongshi, Lu, David W, Fardo, Emily H, Trittschuh, Jesse, Mez, Catherine C, Kaczorowski, Hector, Hernandez Saucedo, Keith F, Widaman, Rachel F, Buckley, Michael J, Properzi, Elizabeth C, Mormino, Hyun Sik, Yang, Theresa M, Harrison, Trey, Hedden, Kwangsik, Nho, Shea J, Andrews, Douglas, Tommet, Niran, Hadad, R Elizabeth, Sanders, Douglas M, Ruderfer, Katherine A, Gifford, Xiaoyuan, Zhong, Neha S, Raghavan, Badri N, Vardarajan, Margaret A, Pericak-Vance, Lindsay A, Farrer, Li San, Wang, Carlos, Cruchaga, Gerard D, Schellenberg, Nancy J, Cox, Jonathan L, Haines, C Dirk, Keene, Andrew J, Saykin, Eric B, Larson, Reisa A, Sperling, Richard, Mayeux, Michael L, Cuccaro, David A, Bennett, Julie A, Schneider, Paul K, Crane, Angela L, Jefferson, Timothy J, Hohman
Publikováno v:
Brain. 145:2541-2554
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer’s disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer’s disease neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9063cca0ef4beb1fea1c62ef8ed6e8af
https://doi.org/10.1093/brain/awac177
https://doi.org/10.1093/brain/awac177