Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Catherine C Going"'
Autor:
Moitrayee Bhattacharyya, Margaret M Stratton, Catherine C Going, Ethan D McSpadden, Yongjian Huang, Anna C Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine L Gee, Tiago Barros, Howard Schulman, Evan R Williams, John Kuriyan
Publikováno v:
eLife, Vol 5 (2016)
Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We
Externí odkaz:
https://doaj.org/article/495a7e27d1bf4339b6867892a9602ba0
Autor:
Dhanir Tailor, Angel Resendez, Alisha M. Birk, Vineet Kumar, George W. Sledge, Edward L. LaGory, Tanya Stoyanova, Rana P. Singh, Ali Ghoochani, Jiangbin Ye, Amato J. Giaccia, Arpit Dheeraj, Dhanya Nambiar, Catherine C. Going, Sanjay V. Malhotra, Quynh-Thu Le, Yang Li, Sharon J. Pitteri
Publikováno v:
British Journal of Cancer
Background To circumvent Warburg effect, several clinical trials for different cancers are utilising a combinatorial approach using metabolic reprogramming and chemotherapeutic agents including metformin. The majority of these metabolic interventions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f14203e2896a840949898ada1bb7619
http://europepmc.org/articles/PMC7851402
http://europepmc.org/articles/PMC7851402
Autor:
Mallesh Pandrala, Meghan A. Rice, Sanjay V. Malhotra, Catherine C. Going, Tanya Stoyanova, James D. Brooks, Fernando García-Marqués, Scott J. Dixon, Shiqin Liu, Merve Aslan, En-Chi Hsu, Sharon J. Pitteri, Dhanir Tailor, Vijayalakshmi Kanchustambham, Rosalie Nolley, Arushi Agarwal, Mark Buckup, Ali Ghoochani, Zintis Inde, Richard N. Zare, Abel Bermudez, Vineet Kumar, Vishnu Shankar, Donna M. Peehl
Publikováno v:
SSRN Electronic Journal.
Among men, prostate cancer is the second leading cause of cancer-associated mortality, with advanced disease remaining a major clinical challenge. We describe a small molecule, SU086, as a new therapeutic strategy for advanced prostate cancer. We dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a780c58adcc0303acec3465f4107b4a3
https://doi.org/10.2139/ssrn.3869894
https://doi.org/10.2139/ssrn.3869894
Autor:
Sharon J. Pitteri, Alexander Honkala, Edward E. Graves, Fernando García-Marqués, Angel Resendez, Vineet Kumar, George W. Sledge, Dhanir Tailor, Quynh-Thu Le, Abel Bermudez, Sanjay V. Malhotra, Mallesh Pandrala, Dhanya Nambiar, Catherine C. Going, Marjan Rafat
Publikováno v:
Cell Chemical Biology. 28:1206-1220.e6
Summary Y box binding protein 1 (YB-1) is a multifunctional protein associated with tumor progression and the emergence of treatment resistance (TR). Here, we report an azopodophyllotoxin small molecule, SU056, that potently inhibits tumor growth and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe915819e7c9a2feb2e1f8e6d1ddcab
https://doi.org/10.1016/j.chembiol.2021.02.014
https://doi.org/10.1016/j.chembiol.2021.02.014
Publikováno v:
Journal of the American Society for Mass Spectrometry, vol 27, iss 6
Electrothermal supercharging (ETS) with electrospray ionization produces highly charged protein ions from buffered aqueous solutions in which proteins have native folded structures. ETS increases the charge of ribonuclease A by 34%, whereas only a 6%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d1cd4430f2351b0ec7de496d289eb4
https://doi.org/10.1007/s13361-016-1350-z
https://doi.org/10.1007/s13361-016-1350-z
Autor:
Sharon J. Pitteri, Meghan A. Rice, Sanjay V. Malhotra, Catherine C. Going, Vineet Kumar, Tanya Stoyanova, Mallesh Pandrala, Dhanir Tailor, Alisha M. Birk
Publikováno v:
J Proteome Res
Triple negative breast cancer is an aggressive, heterogeneous disease with high recurrence and metastasis rates even with modern chemotherapy regimens and thus is in need of new therapeutics. Here, three novel synthetic analogues of chalcones, plant-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e146560d09bc49671f2d3adbd74371a
https://europepmc.org/articles/PMC8078626/
https://europepmc.org/articles/PMC8078626/
Autor:
David Feldman, Kenneth Lau, Ludmila Alexandrova, Sharon J. Pitteri, Christine Y. Yeh, Catherine C. Going
PURPOSE: 27-hydroxycholesterol (27HC), an endogenous selective estrogen receptor modulator (SERM), drives the growth of estrogen receptor-positive (ER+) breast cancer. 1,25-dihydroxyvitamin D (1,25(OH)(2)D), the active metabolite of vitamin D, is kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a4529c7cf9f14c8307b8fc7611615
https://europepmc.org/articles/PMC6381934/
https://europepmc.org/articles/PMC6381934/
Autor:
Angel Resendez, Dhanir Tailor, Sharon J. Pitteri, Catherine C. Going, Sanjay V. Malhotra, Vineet Kumar
Publikováno v:
Cancer Research. 79:5275-5275
Hyperglycemic and hyper insulin condition are the signature symptoms for type two diabetes which is the most favorable condition for the development of cancer. Women having a type two diabetes has 20-27% high risk to develop breast cancer including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abab1bdaab4c0375af6443fbb0b8b92e
https://doi.org/10.1158/1538-7445.am2019-5275
https://doi.org/10.1158/1538-7445.am2019-5275
Autor:
Caleb Cassidy-Amstutz, David Quintanilla, Luke M. Oltrogge, David F. Savage, Catherine C. Going, Antony Lee, Evan R. Williams, Alexandra East-Seletsky, Poh Teng
Publikováno v:
Biochemistry. 55(24)
The encapsulation of enzymes and other proteins within a proteinaceous shell has been observed in many bacteria and archaea, but the function and utility of many such compartments are enigmatic. Efforts to study these functions have been complicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e84aa034df3b5e3f413a5aee551247b
https://pubmed.ncbi.nlm.nih.gov/27224728
https://pubmed.ncbi.nlm.nih.gov/27224728
Autor:
Howard Schulman, Christine L. Gee, Ethan D McSpadden, Nishant Pappireddi, Tiago Barros, Catherine C. Going, Yumeng Melody Cao, Anna Elleman, John Kuriyan, Margaret M. Stratton, Moitrayee Bhattacharyya, Pawel Burkhardt, Anna C. Susa, Evan R. Williams, Yongjian Huang
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Activation triggers the exchange of subunits in Ca2+/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bbef8810c5879e2e95eb9783fd01018
http://europepmc.org/articles/PMC4859805
http://europepmc.org/articles/PMC4859805