Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Catherine Brisbare-Roch"'
Autor:
Christoph Boss, Catherine Brisbare-Roch, Francois Jenck, Hamed Aissaoui, Ralf Koberstein, Thierry Sifferlen, Thomas Weller
Publikováno v:
CHIMIA, Vol 62, Iss 12 (2008)
Orexins are hypothalamic neuropeptides interacting with G-protein coupled receptors in the brain. They play a role in the regulation of sleep–wake cycles in mammals, as suggested by the deficits in orexinergic function that are associated with rode
Externí odkaz:
https://doaj.org/article/31bc9922a0be4dd6b76a6293a0e72733
Autor:
Audrey Chardonneau, Thierry Sifferlen, John Gatfield, Hamed Aissaoui, Alexander Treiber, Jodi T. Williams, Francois Jenck, Christine Brotschi, Johannes Hoecker, Bibia Heidmann, Christoph Boss, Romain Siegrist, Emmanuelle Cottreel, Catherine Brisbare-Roch, Amandine Boller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1201-1208
Starting from a thiazolidin-4-one HTS hit, a novel series of substituted lactams was identified and developed as dual orexin receptor antagonists. In this Letter, we describe our initial efforts towards the improvement of potency and metabolic stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35567abd068fe7a262e99b0bc0448ced
https://doi.org/10.1016/j.bmcl.2013.12.092
https://doi.org/10.1016/j.bmcl.2013.12.092
Autor:
Catherine Brisbare-Roch, Thierry Sifferlen, Ralf Koberstein, Amandine Boller, Thomas Weller, Christoph Boss, John Gatfield, Francois Jenck, Emmanuelle Cottreel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2212-2216
A novel series of non-peptidic OX1R/OX2R orexin receptor antagonists was prepared by heterocyclic replacement of the dimethoxyphenyl moiety contained in the tetrahydroisoquinoline core skeleton of almorexant. Introduction of substituted imidazole moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a7765b5cad3a5e2e4846369aea1e59
https://doi.org/10.1016/j.bmcl.2013.01.088
https://doi.org/10.1016/j.bmcl.2013.01.088
Publikováno v:
Journal of Medicinal Chemistry. 52:891-903
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7d608f3b2804963273fae00fb36308
https://doi.org/10.1021/jm801296d
https://doi.org/10.1021/jm801296d
Autor:
Thomas Weller, Hamed Aissaoui, Francois Jenck, Patrick Hess, Susan Flores, Ralf Koberstein, Petra Hoever, Catherine Brisbare-Roch, Jasper Dingemanse, Michael Scherz, Joop M. A. van Gerven, Oliver Nayler, Sanne de Haas, Stephan Buchmann, Walter Fischli, Martine Clozel, Changbin Qiu, Celia Mueller
Publikováno v:
Nature Medicine. 13:150-155
Orexins are hypothalamic peptides that play an important role in maintaining wakefulness in mammals. Permanent deficit in orexinergic function is a pathophysiological hallmark of rodent, canine and human narcolepsy. Here we report that in rats, dogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d0f77b48bbd6b76562acdaba22e991
https://doi.org/10.1038/nm1544
https://doi.org/10.1038/nm1544
Autor:
Hendrik Dietrich, John Gatfield, Michel A. Steiner, Catherine Brisbare-Roch, Alexander Treiber, Francois Jenck, Christoph Boss
Publikováno v:
ChemMedChem. 8(6)
Stress relief: Orexin neuropeptides regulate arousal and stress processing through orexin receptor type 1 (OXR-1) and 2 (OXR-2) signaling. A selective OXR-1 antagonist, represented by a phenylglycine-amide substituted tetrahydropapaverine derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f522976865e88cba7f0be255780b9cb
https://pubmed.ncbi.nlm.nih.gov/23589487
https://pubmed.ncbi.nlm.nih.gov/23589487
Autor:
Rolf Studer, Daniel S. Strasser, Michel A. Steiner, Francois Jenck, Carla Sciarretta, Catherine Brisbare-Roch
Publikováno v:
Psychoneuroendocrinology. 38(4)
Summary The orexin neuropeptide system regulates wakefulness and contributes to physiological and behavioral stress responses. Moreover, a role for orexins in modulating hypothalamus–pituitary–adrenal (HPA) axis activity has been proposed. Brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcfa2311f86b55f445840c1e8c31412
https://pubmed.ncbi.nlm.nih.gov/22917622
https://pubmed.ncbi.nlm.nih.gov/22917622
Autor:
Hugues Lecourt, Francois Jenck, Michel A. Steiner, Daniel S. Strasser, Catherine Brisbare-Roch
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 36(4)
Current insomnia treatments such as γ-aminobutyric acid (GABA) receptor modulators are associated with sedative and muscle-relaxant effects, which increase when drug intake is combined with alcohol. This study compared the novel sleep-enabling compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c60e4cdf234523e5a1335a15f5b1a2
https://pubmed.ncbi.nlm.nih.gov/21150905
https://pubmed.ncbi.nlm.nih.gov/21150905
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f204d724b5635924d3c014ddb974df1e
https://doi.org/10.1002/chin.201045249
https://doi.org/10.1002/chin.201045249
Autor:
Thierry Sifferlen, Thomas Weller, Catherine Brisbare-Roch, Francois Jenck, Christoph Boss, Ralf Koberstein, John Gatfield, Hamed Aissaoui, Emmanuelle Cottreel, Markus Gude
Publikováno v:
ChemInform. 41
A novel series of dual orexin receptor antagonists was prepared by heteroaromatic five-membered ring system replacement of the dimethoxyphenyl moiety contained in the tetrahydroisoquinoline core skeleton of almorexant. Thus, replacement of the dimeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f446c4cb354759c9f066cde72ba1480
https://doi.org/10.1002/chin.201029174
https://doi.org/10.1002/chin.201029174