In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

Autor: Ann L. Daugherty, Stefan T. Yohe, Daniela Bumbaca Yadav, Hanne Kinnunen Bown, Randall J. Mrsny, Catherine Bonn, Thomas W. Patapoff

Publikováno v: Bown, H K, Bonn, C, Yohe, S T, Yadav, D B, Patapoff, T W, Daugherty, A L & Mrsny, R J 2018, ' In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies ', Journal of Controlled Release, vol. 273, pp. 13-20 . https://doi.org/10.1016/j.jconrel.2018.01.015

Monoclonal antibodies (mAbs), which are now more frequently administered by subcutaneous (SC) injection rather than intravenously, have become a tremendously successful drug format across a wide range of therapeutic areas. Preclinical evaluations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255ef842da5c5b4dc55cb9b9d55e8f86
https://pubmed.ncbi.nlm.nih.gov/29355621

Enfance abandonnée au XVIIIe siècle en Franche-Comté : L'accueil des enfants trouvés par l'hôpital du Saint-Esprit de Besançon

Autor: Bernard Preux

À Besançon, l'hôpital du Saint-Esprit, dit'des enfants trouvés', se chargea de l'accueil des orphelins dès le début du XVIIIe siècle. La mission des hospitaliers consistait à recueillir ces enfants, les élever et, pour ceux qui survivaient,