Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Catherine B. Lazier"'
Publikováno v:
The Prostate. 58:130-144
Background Reduction of T to DHT by 5alphaR in the prostate enhances androgenic activity for most targets. Inhibition of 5alphaR activity with finasteride attenuates androgen action in men and animal models. The objective of this study was to compare
Publikováno v:
The Prostate. 42:203-210
BACKGROUND Insulin-like growth factor-binding proteins (IGFBPs)-2, -4, and -5 are associated with upregulation of apoptosis in the ovary. The purpose of this study was to assess the roles of IGF-I and IGFBPs during involution of the prostate. Frozen
Publikováno v:
Endocrinology. 140:4509-4515
Testosterone (T), the major circulating androgen, must be converted to dihydrotestosterone (DHT) by the enzyme 5α-reductase (5α-R) to be maximally active in the prostate. The present study was designed to determine the relative potency of T and DHT
Publikováno v:
The Prostate. 35:273-278
BACKGROUND Insulin-like growth factor binding protein (IGFBP)-5 has been proposed as a signal for apoptosis in the ovary. To determine the relationship between IGFBP-5 and apoptosis during regression of the androgen-deprived prostate, rats were castr
Publikováno v:
General and Comparative Endocrinology. 104:321-329
Treatment of mature female tilapia (Oreochromis niloticus) with high levels of androgen (17 alpha-methyltestosterone, 17 alpha MT) results in a pronounced decline in plasma vitellogenin levels as determined by gel electrophoresis. Total RNA extracted
Autor:
Jonathan M. Wright, Eileen M. Denovan-Wright, Christopher McCormick, N.Bruce Ramsey, Catherine B. Lazier
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 113:269-273
Atlantic cod ( Gadus morhua ) transferrin cDNAs were isolated from a liver cDNA library using a cod transferrin-derived polymerase chain reaction product as a hybridization probe. The composite nucleotide sequence of two overlapping clones was 2223 b
Autor:
Richard W. Norman, S Whitefield, A P Manning, Roger S. Rittmaster, Catherine B. Lazier, G Rowden, A S Wright, Lynn Thomas
Publikováno v:
Endocrinology. 136:741-748
Castration causes cell loss in the rat ventral prostate through a process called apoptosis. Although 5 alpha-reductase inhibition also causes prostate cell loss, the mechanisms involved have been debated. To investigate this question further, we have
Autor:
M.E. Mackay, Catherine B. Lazier
Publikováno v:
General and Comparative Endocrinology. 89:255-266
We have examined the effect of ambient water temperature on the ability of juvenile rainbow trout to respond to estradiol (E2) injection with vitellogenin (Vg) synthesis. Vg appeared in serum within 24 hr of E2 injection in fish kept at 15 degrees an
Publikováno v:
Gene. 118:197-204
We have determined the sequence of the 1003-bp control region (also referred to as the ‘displacement-loop region’) and flanking tRNA genes in the mitochondrial DNA (mtDNA) of the rainbow trout, Oncorhynchus mykiss. This region has the same overal
Autor:
Catherine B. Lazier, Richard W. Norman, Andrew P. Manning, Roger S. Rittmaster, Katherine E. Magor
Publikováno v:
Molecular Endocrinology. 5:1023-1029
Castration reduces prostate size and causes intraprostatic testosterone (T) and dihydrotestosterone (DHT) to fall to very low levels. 5 alpha-Reductase inhibition also reduces prostate size, but results in a marked increase in intraprostatic T levels