Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Catherine B. Kirn Safran"'
Autor:
Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B. Kirn Safran, Anja Nohe
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
Abstract Background Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a no
Externí odkaz:
https://doaj.org/article/ae412cb4bb75458981bdb62402bc4691
Autor:
Xinnian Chen, Karen L. Myhr, Melissa A. Fleegal-DeMotta, Catherine B. Kirn-Safran, Alan H. Savitzky, Talitha van der Meulen
Publikováno v:
Advances in Physiology Education
This article captures a collective reflection on the successes and challenges we experienced when teaching physiology laboratories online during the COVID-19 pandemic. Physiology instructors from six institutions discussed their own efforts to redesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc8cfc3b22c5be5d79742e8574ac2f5
https://doi.org/10.1152/advan.00022.2021
https://doi.org/10.1152/advan.00022.2021
Autor:
Shaopeng Pei, Shubo Wang, Jerahme R. Martinez, Ashutosh Parajuli, Catherine B. Kirn-Safran, Mary C. Farach-Carson, X. Lucas Lu, Liyun Wang
Publikováno v:
Genes, Vol 13, Iss 72, p 72 (2022)
Genes; Volume 13; Issue 1; Pages: 72
Genes
Genes; Volume 13; Issue 1; Pages: 72
Genes
The proteoglycan-containing pericellular matrix (PCM) controls both the biophysical and biochemical microenvironment of osteocytes, which are the most abundant cells embedded and dispersed in bones. As a molecular sieve, osteocytic PCMs not only regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05a53f34e801848c0bbd1173a2fffad
https://www.mdpi.com/2073-4425/13/1/72
https://www.mdpi.com/2073-4425/13/1/72
Autor:
Hongbo Zhao, Shaopeng Pei, X. Lucas Lu, Jerahme R. Martinez, Ashutosh Parajuli, Mary C. Farach-Carson, Liyun Wang, Catherine B. Kirn-Safran, X. Sherry Liu
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 198 (2020)
Biomolecules
Volume 10
Issue 2
Biomolecules
Volume 10
Issue 2
Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal dysplasia i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19472d953170b388cdf9c1c8b041a54e
https://www.mdpi.com/2218-273X/10/2/198
https://www.mdpi.com/2218-273X/10/2/198
Autor:
Xinqiao Jia, Catherine B. Kirn Safran, Padma Pradeepa Srinivasan, Xian Xu, Anja Nohe, Hemanth Akkiraju
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We recently designed a novel bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afceb97621b3dbd7042e3630eb93ebe
http://link.springer.com/article/10.1186/s13287-017-0537-y
http://link.springer.com/article/10.1186/s13287-017-0537-y
Autor:
Xiaozhou Zhou, Liyun Wang, Nadia Lepori-Bui, Laura G. Sloofman, Peter V. Fomin, Mary C. Farach-Carson, Catherine B. Kirn-Safran, Dylan Andrew Lowe
Publikováno v:
Calcified Tissue International. 95:29-38
Perlecan/Hspg2 (Pln) is a large heparan sulfate proteoglycan abundant in the extracellular matrix of cartilage and the lacuno-canalicular space of adult bones. While Pln function during cartilage development is critical, evidenced by deficiency disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139bde31baa02a4612975d4876230206
https://doi.org/10.1007/s00223-014-9859-2
https://doi.org/10.1007/s00223-014-9859-2
Autor:
Xiaowei Sherry Liu, William R. Thompson, Liyun Wang, Jun Pan, Catherine B. Kirn-Safran, Xiaohan Lai, Wen Li, Christopher Price, Bin Wang, Wei Ju Tseng, Hong Zhang, Tonima R Quabili, Mary C. Farach-Carson
Publikováno v:
Journal of Bone and Mineral Research. 29:878-891
The pericellular matrix (PCM), a thin coating surrounding nearly all mammalian cells, plays a critical role in many cell-surface phenomena. In osteocytes, the PCM is believed to control both “outside-in” (mechanosensing) and “inside-out” (sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::988bd3b36ad06e4a51d52c7abd0e4a3a
https://doi.org/10.1002/jbmr.2105
https://doi.org/10.1002/jbmr.2105
Autor:
William R. Thompson, Sarah Y. McCoy, Kerry A. Falgowski, Erica M. Selva, Padma Pradeepa Srinivasan, Catherine B. Kirn-Safran
Publikováno v:
Bone. 51:224-231
Increased proteoglycan (PG) synthesis is essential for the stimulation of cartilage repair processes that take place during the reversible phase of osteoarthritis (OA). In articular cartilage, xylosyltransferase 1 (Xylt1) is the key enzyme that initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08246b1a2d4410a562b850b54793e538
https://doi.org/10.1016/j.bone.2011.11.012
https://doi.org/10.1016/j.bone.2011.11.012
Autor:
Catherine B Kirn-Safran, Sung Ok Yoon, Soonmoon Yoo, Christopher J. Donnelly, N. Carolyn Schanen, Chhavy Tep, Gary J. Bassell, Jeffery L. Twiss, Chunsu Jiang, Dianna E. Willis, Jan van Minnen, Mei Xu, Arthur W. English
Publikováno v:
The EMBO Journal. 30:4665-4677
Subcellular localization of mRNAs is regulated by RNA–protein interactions. Here, we show that introduction of a reporter mRNA with the 3′UTR of β ‐actin mRNA competes with endogenous mRNAs for binding to ZBP1 in adult sensory neurons. ZBP1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05121451be60e9467948ed95618269f7
https://doi.org/10.1038/emboj.2011.347
https://doi.org/10.1038/emboj.2011.347
Autor:
Laura G. Sloofman, Kostas Verdelis, Catherine B. Kirn-Safran, Lyudmila Spevak, Adele L. Boskey, Mary C. Farach-Carson, Mistuo Yamauchi, Majd Zayzafoon, Lynn M. Opdenaker
Publikováno v:
Bone. 47:93-101
Mice lacking HIP/RPL29, a component of the ribosomal machinery, display increased bone fragility. To understand the effect of sub-efficient protein synthetic rates on mineralized tissue quality, we performed dynamic and static histomorphometry and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6bf557aad23bb41875fbe3ab38c54b
https://doi.org/10.1016/j.bone.2010.03.015
https://doi.org/10.1016/j.bone.2010.03.015