Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Catherine B Lawrence"'
Autor:
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Barry W McColl, Blanca Díaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L Crawford, Colin Smith, Denis Vivien, Fiona H McLean, Frances Wiseman, Gaia Brezzo, Giovanna Lalli, Harry A T Pritchard, Hugh S Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S Stringer, MLJ Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H Hainsworth, Joanna M Wardlaw
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 5, Iss , Pp 100189- (2023)
Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which e
Externí odkaz:
https://doaj.org/article/9ffe49ccbd5b476183d732a9dab4e59d
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99226 (2014)
Alzheimer's disease (AD) is not normally diagnosed until later in life, although evidence suggests that the disease starts at a much earlier age. Risk factors for AD, such as diabetes, hypertension and obesity, are known to have their affects during
Externí odkaz:
https://doaj.org/article/91f055ede04b4f5685d1868c7bb7d15c
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45179 (2012)
Alzheimer's disease (AD) is associated with non-cognitive symptoms such as changes in feeding behaviour that are often characterised by an increase in appetite. Increased food intake is observed in several mouse models of AD including the triple tran
Externí odkaz:
https://doaj.org/article/3efa09a55ff444849276fc6846b07201
Autor:
Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie Jerome-Majeweska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/54d8d756b504456cad4fadda12ce0a6b
Autor:
Samuel Drinkall, Catherine B. Lawrence, Bernadino Ossola, Samuel Russell, Clare Bender, Nicola B. Brice, Lee A. Dawson, Michael Harte, David Brough
Publikováno v:
Glia. 70:1301-1316
The NLRP3 (NLR family, pyrin domain containing 3) inflammasome is a multi-protein complex responsible for the activation of caspase-1 and the subsequent cleavage and activation of the potent proinflammatory cytokines IL-1β and IL-18, and pyroptotic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd23d64a1806c65a4cb1a3005dd0914
https://doi.org/10.1002/glia.24174
https://doi.org/10.1002/glia.24174
Autor:
Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for t
Externí odkaz:
https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c
Autor:
Bernardino Ossola, Ali Rifat, Anna Rowland, Helen Hunter, Samuel Drinkall, Clare Bender, Mayida Hamlischer, Martin Teall, Russell Burley, Daneil F. Barker, David Cadwalladr, Louise Dickson, Jason M.K. Lawrence, Jenna R.M. Harvey, Marina Lizio, Xiao Xu, Edel Kavanagh, Toni Cheung, Steve Sheardown, Catherine B. Lawrence, Michael Harte, David Brough, Christian Madry, Kim Matthews, Kevin Doyle, Keith Page, Justin Powell, Nicola L. Brice, Roland W. Bürli, Mark B. Carlton, Lee A. Dawson
Publikováno v:
Neuropharmacology. 224
Neuroinflammation, specifically the NLRP3 inflammasome cascade, is a common underlying pathological feature of many neurodegenerative diseases. Evidence suggests that NLRP3 activation involves changes in intracellular K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dc2da491de466f3d474771aad12f3b
https://pubmed.ncbi.nlm.nih.gov/36375694
https://pubmed.ncbi.nlm.nih.gov/36375694
Autor:
Alison E. Mather, Jack Rivers-Auty, Harry G. Spence, Christopher Hoyle, Michael J.D. Daniels, Shi Yu, Margaret Jane Gordon, James Cook, David Brough, Paul T. Kennedy, John H. Beattie, Amy Bradley, Victor S. Tapia, Ruth Peters, Samuel Drinkall, Te-Chen Tzeng, Claire S. White, Catherine B. Lawrence, Jack Peter Green
Publikováno v:
The Journal of Neuroscience
Alzheimer's disease is a devastating neurodegenerative disease with a dramatically increasing prevalence and no disease-modifying treatment. Inflammatory lifestyle factors increase the risk of developing Alzheimer's disease. Zinc deficiency is the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7018a3cbf7c3fb7a28bf046d53d9335
http://europepmc.org/articles/PMC8018890
http://europepmc.org/articles/PMC8018890
Autor:
Sharon Hulme, John R. Grainger, Stuart M. Allan, Conor O'Boyle, Craig J. Smith, Siddharth Krishnan, Catherine B. Lawrence
Publikováno v:
Clinical and Experimental Immunology
Krishnan, S, O'Boyle, C, Smith, C, Hulme, S, Allan, S, Grainger, J & Lawrence, C B 2020, ' A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells ', Clinical and experimental immunology . https://doi.org/10.1111/cei.13551
Krishnan, S, O'Boyle, C, Smith, C, Hulme, S, Allan, S, Grainger, J & Lawrence, C B 2020, ' A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells ', Clinical and experimental immunology . https://doi.org/10.1111/cei.13551
Stroke affects millions of people across the globe and infections following a stroke often lead to death or disability in patients. Looking rapidly after a stroke in patients, we identify early alterations to the innate and adaptive cells in circulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5babe520472a839e7d9373f7ff81a79
http://europepmc.org/articles/PMC7874838
http://europepmc.org/articles/PMC7874838
Autor:
David Brough, Kanisa Arunasalam, Elena Di Daniel, Sohaib Nizami, Tryfon Zarganes-Tzitzikas, James Cook, Catherine B. Lawrence, John B. Davis, Jack Peter Green
Publikováno v:
Immunology
Nizami, S, Arunasalam, K, Green, J, Cook, J, Lawrence, C B, Zarganes-Tzitzikas, T, Davis, J B, Daniel, E D & Brough, D 2020, ' Inhibition of the NLRP3 inflammasome by HSP90 inhibitors ', Immunology . https://doi.org/10.1111/imm.13267
Nizami, S, Arunasalam, K, Green, J, Cook, J, Lawrence, C B, Zarganes-Tzitzikas, T, Davis, J B, Daniel, E D & Brough, D 2020, ' Inhibition of the NLRP3 inflammasome by HSP90 inhibitors ', Immunology . https://doi.org/10.1111/imm.13267
Summary Excessive and dysregulated inflammation is known to contribute to disease progression. HSP90 is an intracellular chaperone known to regulate inflammatory processes including the NLRP3 inflammasome and secretion of the pro‐inflammatory cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca736ad5b681f06e78f717d791cf8eb
https://doi.org/10.1111/imm.13267
https://doi.org/10.1111/imm.13267