Výsledky vyhledávání - "Catherine Alexakis"

Implication of the satellite cell in dystrophic muscle fibrosis: a self-perpetuating mechanism of collagen overproduction

Autor: George Bou-Gharios, Catherine Alexakis, Terence A. Partridge

Publikováno v: American Journal of Physiology-Cell Physiology. 293:C661-C669

Because of its mechanical function, skeletal muscle is heavily influenced by the composition of its extracellular matrix (ECM). Fibrosis generated by chronic damage, such as occurs in muscular dystrophies, is thus particularly disastrous in this tiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e608068bd793fc286be1b934ee5201c2
https://doi.org/10.1152/ajpcell.00061.2007

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Regulation of the collagen phenotype expression of gamma-irradiated vascular smooth muscle cells by heparan mimetics (RGTA)

Autor: Patricia Mestries, Denis Barritault, Carine Strup, P. Kern, Catherine Alexakis, Denis Mathé, Jean-Pierre Caruelle

Publikováno v: Journal of Biomedical Materials Research Part A. :594-602

Restenosis is characterized by vascular smooth muscle cell (VSMC) proliferation and accumulation of col- lagen III in a hypertrophic and disorganized extracellular matrix. Restenosis is prevented by antimitotic agents or irradiation but no significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::014d1ee3e61d2de4175f3b80527d938a
https://doi.org/10.1002/jbm.a.30119

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Reversal of abnormal collagen production in Crohn's disease intestinal biopsies treated with regenerating agents

Autor: Jean-Pierre Caruelle, Jean-Pierre Gendre, A Sezeur, D Barritault, P. Kern, H. Mosnier, Jacques Cosnes, Laurent Beaugerie, M. Malafosse, Catherine Alexakis, D. Gallot

Publikováno v: Gut. 53:85-90

Background: Crohn’s disease (CD) is characterised by inflammation, muscle layer overgrowth, and collagenous fibrosis of the intestinal tract, with no effective therapy against collagen accumulation. Aims: We quantified production of collagen in res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db3982ca801cc0727ae736cb407ee0b
https://doi.org/10.1136/gut.53.1.85

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Heparan mimetic regulates collagen expression and TGF‐β1 distribution in gamma‐irradiated human intestinal smooth muscle cells

Autor: Carine Strup, Ahmed Guettoufi, Denis Barritault, Christel Barbaud, Jean-Pierre Caruelle, Denis Mathé, Catherine Alexakis, Patricia Mestries, P. Kern

Publikováno v: The FASEB Journal. 15:1546-1554

Radiation-induced intestinal fibrosis is characterized by collagen accumulation, a process in which TGF-beta1 plays a key role. We analyzed the effects of gamma radiation on collagen expression and TGF-beta1 distribution in human intestinal smooth mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa12bba5494a36db0a8f532b7f0d8994
https://doi.org/10.1096/fj.00-0756com

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Specific RGTA increases collagen V expression by cultured aortic smooth muscle cells via activation and protection of transforming growth factor-β1

Autor: Denis Barritault, Arlette Duchesnay, Catherine Alexakis, Dulce Papy-Garcia, P. Kern, Patricia Mestries, Jean Pierre Caruelle

Publikováno v: Matrix Biology. 20:171-181

Regenerating agents (RGTA) are defined as heparan sulfate mimics, which in vivo stimulate tissue repair. RGTA are obtained by controlled grafting of carboxymethyl and sulfate groups on dextran polymers. RGTA are selected in vitro, on their ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa71abe1bfa2214f0a65a09fef5c06c6
https://doi.org/10.1016/s0945-053x(01)00131-7

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Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis

Autor: William R. Otto, Candice Roufosse, Richard Poulsom, George Bou-Gharios, Rosemary Jeffery, Sarah B. Khan, Evangelia I Prodromidi, Julia Alter, Catherine Alexakis, H. Terence Cook

Publikováno v: Journal of the American Society of Nephrology : JASN. 17(3)

Interstitial fibroblasts play a central role in kidney fibrosis. Their origin is debated, with recent data indicating a contribution of bone marrow (BM)-derived cells to the expanded population of interstitial cells after kidney damage in animals and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200cfa2bd028b982858338eda5625112
http://ora.ox.ac.uk/objects/uuid:4c71bd2c-a0cb-442a-8e9b-19c32a06521c

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RGTA OTR4120, a heparan sulfate mimetic, is a possible long-term active agent to heal burned skin

Autor: P. Kern, Eric Huet, Denis Barritault, Catherine Alexakis, Emmanuel Petit, Stephanie Garcia-Filipe, Marie-Emmanuelle Kerros, Jean-Pierre Caruelle, Dominique Ledoux, Veronique Barbier-Chassefiere

Publikováno v: Journal of Biomedical Materials Research Part A
Journal of Biomedical Materials Research Part A, Wiley, 2006, Epub ahead of
HAL

Burn-related skin fibrosis leads to loss of tissue function and hypertrophic scar formation with damaging consequences for the patient. There is therefore a great need for an efficient agent to treat burned skin. We report that ReGeneraTing Agent (RG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f7c876c48b9895f293d6f92a7519a1
https://hal.archives-ouvertes.fr/hal-00109611

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Structurally different RGTAs modulate collagen-type expression by cultured aortic smooth muscle cells via different pathways involving fibroblast growth factor-2 or transforming growth factor-beta1

Autor: Stéphanie Garcia, Catherine Alexakis, Emmanuel Petit, Veronique Chessefiere Barbier, Patrick Kern, Patricia Mestries, Dulce Papy-Garcia, Marie-Astride Sagot, Jean Pierre Caruelle, D. Barritault

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(10)

We have engineered polymers called ReGeneraTing Agents (RGTAs), which mimic the protecting and potentiating properties of heparan sulfates toward heparin-binding growth factors (HBGF). RGTAs have been shown to optimize cell growth and regulate collag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08380512d24ccbcbd82819c54a6cf381
https://pubmed.ncbi.nlm.nih.gov/15132978

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Col1a2 enhancer regulates collagen activity during development and in adult tissue repair

Autor: Qi-Long Lu, George Bou-Gharios, David Abraham, Catherine Alexakis, Terence A. Partridge, Markella Ponticos, Carol M. Black

Publikováno v: Matrix biology : journal of the International Society for Matrix Biology. 22(8)

An enhancer region in the type I collagen alpha 2 chain (pro-Col1a2) promoter has been previously identified approximately -17 kb away from the transcription start site. This upstream region termed the far-upstream-enhancer contains three DNAse I hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6e57c4fc5e5f3da4c8aab951caefbe
https://pubmed.ncbi.nlm.nih.gov/15062855

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