Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Catherine A. Oleykowski"'
Autor:
Mary Ann Hardwicke, Hong Lin, Karl F. Erhard, John D. Martin, Ren Xie, Kaushik Raha, Rosanna Tedesco, Jin Zeng, Yanqiu Qian, Patricia M. Kratz, Yong Jiang, Ted Cecconie, Stan F. Martens, Angela Smallwood, Patrick McDevitt, James F. Mack, Baoguang Zhao, Stephenie B. Chen, Anthony J. Jurewicz, Juan I. Luengo, Mark J. Schulz, Nino Campobasso, Catherine A. Oleykowski, Lawrence M. Szewczuk, Alan R. Rendina, Cynthia M. Rominger, Benjamin J. Schwartz, Leng Nickels, Junya Qu, Jacques Briand
Publikováno v:
ACS Medicinal Chemistry Letters. 7:217-222
A novel series of potent and selective hexokinase 2 (HK2) inhibitors, 2,6-disubstituted glucosamines, has been identified based on HTS hits, exemplified by compound 1. Inhibitor-bound crystal structures revealed that the HK2 enzyme could adopt an "in
Autor:
Octerloney B. McDonald, Carla A. Donatelli, William F. Huffman, Toshihiro Hamajima, Christine Thompson, Kelly E. Fisher, Martha A. Sarpong, Jamin C Wang, David Sutton, Dashyant Dhanak, Peter J. Tummino, Jun Tang, Ken A. Newlander, Zhihong V Lai, Hong Xiang, Kosuke Sasaki, Domingos J. Silva, Mary Ann Hardwicke, Jerry L. Adams, Cynthia A. Parrish, Schmidt Stanley J, Denis R. Patrick, Hiroko Nakamura, Jingsong Yang, Catherine A. Oleykowski, Robert A. Copeland, Amita M. Chaudhari, Ramona Plant, David H. Drewry, Kristin K Koretke-Brown, Nicholas D. Adams, Joelle Lorraine Burgess
Publikováno v:
Journal of Medicinal Chemistry. 53:3973-4001
The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of tumors with Aurora kinase amplification. Herein we
Autor:
Ken A. Newlander, Denis R. Patrick, Dashyant Dhanak, Jingsong Yang, Mary Ann Hardwicke, Catherine A. Oleykowski, Jerry L. Adams, Zhihong Lai, David Sutton, Jamin Wang, Ramona Plant, Qiaoyin Liao, Katherine G. Moss
Publikováno v:
Molecular Cancer Therapeutics. 8:1808-1817
The protein kinases, Aurora A, B, and C have critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. GSK1070916, is a novel ATP competitive inhibitor that is highly potent and selective for Aurora B/
Autor:
Nagendra S. Kodali, Catherine A. Oleykowski, Anthony T. Yeung, Maxim Pimkin, Lauryn Blakesley, C. Glenn Miller
Publikováno v:
Biochemical and Biophysical Research Communications. 343:77-84
DNA sequences encoding hypothetical proteins homologous to S1 nuclease from Aspergillus oryzae are found in many organisms including fungi, plants, pathogenic bacteria, and eukaryotic parasites. One of these is the M1 nuclease of Mesorhizobium loti w
Publikováno v:
BioTechniques. 29:44-48
Publikováno v:
Nucleic Acids Research. 26:4597-4602
We have discovered a useful new reagent for mutation detection, a novel nuclease CEL I from celery. It is specific for DNA distortions and mismatches from pH 6 to 9. Incision is on the 3'-side of the mismatch site in one of the two DNA strands in a h
Autor:
Alain Jacquemin-Sablon, B. Lambert, Jean-Luc Jestin, Claude Prétot, Pascale Bréhin, Jean-Claude Chottard, Anthony T. Yeung, Jean-Bernard Le Pecq, Catherine A. Oleykowski, Patrick Mailliet
Publikováno v:
Journal of Biological Chemistry. 270:21251-21257
The interactions of the Escherichia coli endonuclease UvrAB proteins with the DNA mono- and diadducts of both the cis-racemic exo-[N-2-amino-N-2-methylamino-2,2,1-bicycloheptane]dichloroplatinum(II) (complex 1) and cisplatin (cis-diamminedichloroplat
Autor:
Yan Degenhardt, Catherine A. Oleykowski, Junping Jing, Mary Ann Hardwicke, Richard Wooster, Ramona Plant, Joel Greshock, Christopher Moy, Kurtis E. Bachman
Publikováno v:
Journal of Translational Medicine, Vol 9, Iss 1, p 110 (2011)
Journal of Translational Medicine
Journal of Translational Medicine
Background Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to the clin
Autor:
Catherine A. Oleykowski, Gerald N. Wogan, Janet A. Mayernik, Anthony T. Yeung, John D. Groopman, Lawrence Grossman, Susan E. Lim
Publikováno v:
Journal of Biological Chemistry. 268:7990-8002
The repair by UvrABC endonuclease of two major adducts formed by aflatoxin B1 in DNA was found to be similar. Aflatoxin epoxide was used to generate the aflatoxin B1.N7-guanine adduct which can convert to aflatoxin B1-formamidopyrimidine adduct. The
Autor:
Mary Ann Hardwicke, Jeffrey M. Axten, Carla A. Donatelli, Jesus R. Medina, William H. Miller, Seth W. Grant, Ramona Plant, Hong Xiang, Catherine A. Oleykowski, Qiaoyin Liao
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
Novel Aurora inhibitors were identified truncating clinical candidate GSK1070916. Many of these truncated compounds retained potent activity against Aurora B with good antiproliferative activity. Mechanistic studies suggested that these compounds, de