Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Catherine A. Higgins"'
Autor:
Joel S. Riley, Hajrah Khawaja, Jennifer Fox, Joanna Majkut, Caitriona Holohan, Luke M Humphreys, Jennifer Ferris, Margarita Espona-Fiedler, Daniel B. Longley, Jamie Z. Roberts, Catherine A. Higgins, Paul N. Moynagh, Nyree Crawford, Emma Evergren, Simon S. McDade, Tamas Sessler
Publikováno v:
Roberts, J Z, Holohan, C, Sessler, T, Fox, J, Crawford, N, Riley, J S, Khawaja, H, Majkut, J, Evergren, E, Humphreys, L M, Ferris, J, Higgins, C, Espona-Fiedler, M, Moynagh, P, McDade, S S & Longley, D B 2020, ' The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L) ', Cell Death and Differentiation, vol. 27, pp. 2726–2741 . https://doi.org/10.1038/s41418-020-0539-7
TRAIL-R2 (DR5) is a clinically-relevant therapeutic target and a key target for immune effector cells. Herein, we identify a novel interaction between TRAIL-R2 and the Skp1-Cullin-1-F-box (SCF) Cullin-Ring E3 Ubiquitin Ligase complex containing Skp2
Autor:
Babur Ahmed, Rhona J McVey, Emma J Crosbie, Martyna Kamieniorz, Catherine L. Higgins, Abigail E. Derbyshire, Basil J. Ammori, Akheel A. Syed, Andrew G Renehan, Philip W. Pemberton, Michelle L. MacKintosh, James Bolton, Henry C Kitchener, Mahshid Nickkho-Amiry, Bilal H. Kirmani
Publikováno v:
Mackintosh, M, Derbyshire, A, McVey, R, Bolton, J, Nickkho-Amiry, M, Higgins, C L, Kamieniorz, M, Pemberton, P W, Kirmani, B H, Ahmed, B, Syed, A, Ammori, B, Renehan, A, Kitchener, H & Crosbie, E 2019, ' The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk ', International Journal of Cancer, vol. 144, no. 3, pp. 641-650 . https://doi.org/10.1002/ijc.31913
International Journal of Cancer
International Journal of Cancer
Obesity is the strongest risk factor for endometrial cancer (EC). To inform targeted screening and prevention strategies, we assessed the impact of obesity and subsequent bariatric surgery‐induced weight loss on endometrial morphology and molecular
Publikováno v:
Cancers, Vol 13, Iss 2618, p 2618 (2021)
Cancers
Hamilton, C, Fox, J P, Longley, D B & Higgins, C A 2021, ' Therapeutics Targeting the Core Apoptotic Machinery ', Cancers, vol. 13, no. 11, 2618 . https://doi.org/10.3390/cancers13112618
Cancers
Hamilton, C, Fox, J P, Longley, D B & Higgins, C A 2021, ' Therapeutics Targeting the Core Apoptotic Machinery ', Cancers, vol. 13, no. 11, 2618 . https://doi.org/10.3390/cancers13112618
Simple Summary Cancer develops when the balance between cell death and cell division in tissues is dysregulated. A key focus of cancer drug discovery is identifying therapeutic agents which will selectively kill and eliminate cancer cells from the bo
Publikováno v:
Hamilton, C, Fox, J P, Longley, D B & Higgins, C A 2022, ' Correction: Hamilton et al. Therapeutics targeting the core apoptotic machinery. Cancers 2021, 13, 2618 ', Cancers, vol. 14, no. 6, e1441 . https://doi.org/10.3390/cancers14061441
There was an error in the original publication [...]
Autor:
Simon S. McDade, Christopher J. Scott, Luke M Humphreys, Christopher McCann, Joanna Majkut, Catherine A. Higgins, Tamas Sessler, Jennifer Fox, Kirsty McLaughlin, Tim Harrison, Daniel B. Longley, Jamie Z. Roberts, Nyree Crawford
Publikováno v:
EMBO Reports
Humphreys, L M, Fox, J P, Higgins, C A, Majkut, J, Sessler, T, McLaughlin, K, McCann, C, Roberts, J Z, Crawford, N T, McDade, S S, Scott, C J, Harrison, T & Longley, D B 2020, ' A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis ', EMBO Reports, vol. 21, e49254 . https://doi.org/10.15252/embr.201949254
Humphreys, L M, Fox, J P, Higgins, C A, Majkut, J, Sessler, T, McLaughlin, K, McCann, C, Roberts, J Z, Crawford, N T, McDade, S S, Scott, C J, Harrison, T & Longley, D B 2020, ' A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis ', EMBO Reports, vol. 21, e49254 . https://doi.org/10.15252/embr.201949254
The long FLIP splice form FLIP(L) can act as both an inhibitor and promoter of caspase‐8 at death‐inducing signalling complexes (DISCs) formed by death receptors such as TRAIL‐R2 and related intracellular complexes such as the ripoptosome. Here
Autor:
Jennifer Fox, Catherine A. Higgins, Trevor Perrior, Declan Doherty, Daniel B. Longley, Jamie Z. Roberts, Tim Harrison, Raymond John Boffey
Publikováno v:
Cancer Research. 81:1342-1342
In cancer, evasion of cell death is a fundamental cause of resistance to therapy, prompting the development of therapeutics that reactivate cell death pathways such as Bcl-2 family inhibitors and IAP antagonists. The apoptosis modulator Cellular FLIC
Autor:
Yongqiang, Yang, Catherine H, Higgins, Ibraheem, Rehman, Klibs N, Galvao, Ilana L, Brito, Marcela L, Bicalho, Jeongmin, Song, Hongning, Wang, Rodrigo C, Bicalho
Publikováno v:
Applied and environmental microbiology. 85(6)
Klebsiella pneumoniae is a leading cause of severe infections in humans and dairy cows, and these infections are rapidly becoming untreatable due to the emergence of multidrug-resistant (MDR) strains. However, little is known about the relationship b
Autor:
Daniel B. Longley, Jamie Z. Roberts, Jennifer Fox, Raymond John Boffey, Martin J. Page, Tim Harrison, Sophie Williams, Trevor Perrior, Catherine A. Higgins
Publikováno v:
Cancer Research. 80:5220-5220
Caspase-8 is the initiator caspase for the extrinsic apoptotic pathway and now recognized as the molecular “switch” that controls 3 major forms of programmed cell death: apoptosis, necroptosis and pyroptosis. As such, methods to selectively activ
Autor:
Gerald M. Lawrie, Iou Yih Chen, Catherine L. Higgins, Muthiah Vaduganathan, Salim Isbilir, Pamela Basto, Michael J. Reardon, Leif E. Peterson, Joel D. Morrisett, Periyanan Vaduganathan
Publikováno v:
The Protein Journal. 34:315-328
Ectopic vascular calcification is a significant component of atherosclerotic disease. Osteopontin (OPN), Osteoprotegerin (OPG), Receptor Activator of NFκB Ligand (RANKL), and alkaline phosphatase (ALP) are each thought to play central roles in the c
Autor:
Andrew Young, Rich Williams, Samira Bouazzaoui, Paul B. Mullan, Kishore K.D. Gaddale, Amy Templeman, Zenobia C. D’Costa, Christopher J. Scott, Tim Harrison, Martin O'Rourke, Catherine A. Higgins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2521-2524
This Letter describes the further development and SAR exploration of a novel series of Legumain inhibitors. Based upon a previously identified Legumain inhibitor from our group, we explored the SAR of the carbamate phenyl ring system to probe the P3