Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Catherine A. Hazzalin"'
Publikováno v:
PLoS Biology, Vol 3, Iss 12, p e393 (2005)
A major focus of current research into gene induction relates to chromatin and nucleosomal regulation, especially the significance of multiple histone modifications such as phosphorylation, acetylation, and methylation during this process. We have di
Externí odkaz:
https://doaj.org/article/01f47303f972440b9b4db9e62d61d4d9
Publikováno v:
Methods in Molecular Biology ISBN: 9781493966288
Acid-urea gel electrophoresis offers significant advantages over SDS-PAGE for analysis of post-translational protein modifications, being capable of resolving proteins of similar size but varying in charge. Hence, it can be used to separate protein v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adef7c0b5329f6f480caca5ef8447566
https://doi.org/10.1007/978-1-4939-6630-1_11
https://doi.org/10.1007/978-1-4939-6630-1_11
Autor:
Philip A. Cole, Louis C. Mahadevan, Erin M. Bowers, Catherine A. Hazzalin, Nicholas T. Crump, Rhoda M. Alani
Histone modifications are reported to show different behaviors, associations, and functions in different genomic niches and organisms. We show here that rapid, continuous turnover of acetylation specifically targeted to all K4-trimethylated H3 tails
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f12597e15ea03acf57a6d8020ff3e80
https://doi.org/10.1073/pnas.1100099108
https://doi.org/10.1073/pnas.1100099108
Publikováno v:
Molecular Cell. 15(4):585-594
A question of major current interest is whether histone modification at a given gene correlates simply with transcriptional status or if distinctive modifications appear depending on how that gene is activated. The stress-inducible gene Hsp70 is acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a60856265f030687f943e9b1696377
Autor:
Stuart Thomson, Navita Rampersaud, Catherine A. Hazzalin, Giselle R. Wiggin, J. Simon C. Arthur, Mark H. Dyson, Ana Soloaga, Louis C. Mahadevan
Publikováno v:
The EMBO Journal. 22:2788-2797
Cells respond to mitogenic or stress stimuli by the rapid induction of immediate-early (IE) genes, which occurs concomitantly with the phosphorylation of histone H3 and the high-mobility-group protein HMG-14. In mammalian cells this response is media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905d67290bde2acf03a971f13dfaa7ca
https://doi.org/10.1093/emboj/cdg273
https://doi.org/10.1093/emboj/cdg273
Publikováno v:
Nature Reviews Molecular Cell Biology. 3:30-40
Switching mechanisms that control genes could be viewed either as stable binary switches, in which genes exist in 'on' or 'off' states; or as quantitative rheostat-like switches, in which the rate of transcription is continuously variable and coupled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2317ea86b81844d94ff6fa0881dd59
https://doi.org/10.1038/nrm715
https://doi.org/10.1038/nrm715
Publikováno v:
Journal of Biological Chemistry. 276:6666-6674
Tumor necrosis factor-alpha (TNF-alpha) is a potent proinflammatory cytokine whose synthesis and secretion are implicated in diverse pathologies. Hence, inhibition of TNF-alpha transcription or translation and neutralization of its protein product re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb496a5430c7cd0ae63941dcfcbb0882
https://doi.org/10.1074/jbc.m005486200
https://doi.org/10.1074/jbc.m005486200
Autor:
Sally Rose, Louis C. Mahadevan, Stuart Thomson, Catherine A. Hazzalin, Alison L. Clayton, Michael J. Barratt
Publikováno v:
The EMBO Journal. 18:4779-4793
The nucleosomal response refers to the rapid phosphorylation of histone H3 on serine 10 and HMG-14 on serine 6 that occurs concomitantly with immediate-early (IE) gene induction in response to a wide variety of stimuli. Using antibodies against the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cecd778806bc5d8986856a3797a5c4
https://doi.org/10.1093/emboj/18.17.4779
https://doi.org/10.1093/emboj/18.17.4779
Publikováno v:
Molecular and Cellular Biology. 14:7352-7362
Independent of its ability to block translation, anisomycin intrinsically initiates intracellular signals and immediate-early gene induction [L. C. Mahadevan and D. R. Edwards, Nature (London) 349:747-749, 1991]. Here, we characterize further its act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c01999f69daeb57627ee3f7a73c7660
https://doi.org/10.1128/mcb.14.11.7352-7362.1994
https://doi.org/10.1128/mcb.14.11.7352-7362.1994
Publikováno v:
The EMBO Journal. 13:4524-4535
The rapid, transient induction of 80-100 immediate-early (IE) genes upon mitogenic stimulation occurs irrespective of protein synthesis and is mediated by modification of existing proteins. Two mechanisms, not mutually exclusive, involving modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b6bb4b19b934e410bca38994f596ab
https://doi.org/10.1002/j.1460-2075.1994.tb06774.x
https://doi.org/10.1002/j.1460-2075.1994.tb06774.x