Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Catherine A. Harwood"'
Autor:
Peter Bailey, Rachel A. Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D. Campbell, Emmanouil Dimonitsas, Alexander J. Stratigos, Sarah T. Arron, Jun Wang, Karen Blyth, Charlotte M. Proby, Catherine A. Harwood, Owen J. Sansom, Irene M. Leigh, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies h
Externí odkaz:
https://doaj.org/article/12b4077a59444dd3949da320a9c0d1e9
Publikováno v:
Acta Dermato-Venereologica, Vol 103 (2023)
Abstract is missing Short communication
Externí odkaz:
https://doaj.org/article/b3d99570d7ec437d85c20ae7167db441
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The assessment of the cellular heterogeneity and abundance in bulk tissue samples is essential for characterising cellular and organismal states. Computational approaches to estimate cellular abundance from bulk RNA-Seq datasets have variable perform
Externí odkaz:
https://doaj.org/article/1b0d46cce4604bedab09954cd91ec840
Autor:
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response. Upon act
Externí odkaz:
https://doaj.org/article/8331701216db401fb931473068ce8357
Autor:
Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby, Irene M. Leigh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated w
Externí odkaz:
https://doaj.org/article/d162fea7f7de4883a5d53f89f08c61a7
Autor:
Viviana Mannella, Kira Boehm, Suheyla Celik, Tasnim Ali, Amnah N. Mirza, Mariam El Hasnaouy, Andreas Kaffa, Yanshuang Lyu, Donya Kafaei Golahmadi, Irene M. Leigh, Daniele Bergamaschi, Catherine A. Harwood, Tania Maffucci
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3567 (2021)
Cutaneous squamous cell carcinomas (cSCCs) account for about 20% of keratinocyte carcinomas, the most common cancer in the UK. Therapeutic options for cSCC patients who develop metastasis are limited and a better understanding of the biochemical path
Externí odkaz:
https://doaj.org/article/d1735ca0cd714d07acbd88891bfd7116
Autor:
Patrizia Cammareri, Aidan M. Rose, David F. Vincent, Jun Wang, Ai Nagano, Silvana Libertini, Rachel A. Ridgway, Dimitris Athineos, Philip J. Coates, Angela McHugh, Celine Pourreyron, Jasbani H. S. Dayal, Jonas Larsson, Simone Weidlich, Lindsay C. Spender, Gopal P. Sapkota, Karin J. Purdie, Charlotte M. Proby, Catherine A. Harwood, Irene M. Leigh, Hans Clevers, Nick Barker, Stefan Karlsson, Catrin Pritchard, Richard Marais, Claude Chelala, Andrew P. South, Owen J. Sansom, Gareth J. Inman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cutaneous squamous cell carcinomas is a growing problem but the driver genes causing this remain poorly defined. Here, the authors demonstrate that inactivating driver mutations in TGFBR1 and TGFBR2occur in vemurafenib-induced and sporadic cutaneous
Externí odkaz:
https://doaj.org/article/007e4295faa9467ba2f947c4d342dc0a
Autor:
Karin J. Purdie, Charlotte M. Proby, Hasan Rizvi, Heather Griffin, John Doorbar, Mary Sommerlad, Mariet C. Feltkamp, Els Van der Meijden, Gareth J. Inman, Andrew P. South, Irene M. Leigh, Catherine A. Harwood
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Background: Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic me
Externí odkaz:
https://doaj.org/article/ae66638460604f449b4582a92dea391f
Autor:
Sakinah Hassan, Karin J. Purdie, Jun Wang, Catherine A. Harwood, Charlotte M. Proby, Celine Pourreyron, Nikol Mladkova, Ai Nagano, Sandeep Dhayade, Dimitris Athineos, Matthew Caley, Viviana Mannella, Karen Blyth, Gareth J. Inman, Irene M. Leigh
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3428 (2019)
Background: Cutaneous squamous cell carcinoma (cSCC) incidence continues to rise with increasing morbidity and mortality, with limited treatment options for advanced disease. Future improvements in targeted therapy will rely on advances in genomic/tr
Externí odkaz:
https://doaj.org/article/98119bebc7214a0dae59214416994d70
Autor:
Serena Ramjee, Hanen Mohamedthani, Aditya Umeshkumar Patel, Rebeca Goiriz, Catherine A Harwood, Richard H Osborne, Christina Cheng, Zeeshaan-ul Hasan
Publikováno v:
JMIR Dermatology, Vol 6, p e48981 (2023)
BackgroundGiven the expansion of remote digital dermatology services from the National Health Service, particularly during the COVID-19 pandemic, there is a need for methods that identify patients at risk of digital exclusion to guide equitable repre
Externí odkaz:
https://doaj.org/article/270cae2c93b548b7ae23a062e2cbf86c