Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Catherine A. Christian-Hinman"'
Autor:
Vipendra Kumar, Kwan Young Lee, Anirudh Acharya, Matthew S Babik, Catherine A Christian-Hinman, Justin S Rhodes, Nien-Pei Tsai
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 3, Pp 506-522 (2024)
Abstract Fragile X syndrome (FXS) is the leading cause of inherited autism and intellectual disabilities. Aberrant protein synthesis due to the loss of fragile X messenger ribonucleoprotein (FMRP) is the major defect in FXS, leading to a plethora of
Externí odkaz:
https://doaj.org/article/b326dbbf75824151a5fca593719224e0
Publikováno v:
Epilepsia Open, Vol 8, Iss 4, Pp 1512-1522 (2023)
Abstract Objective Sex differences in epilepsy appear driven in part due to effects of gonadal steroids, with varying results in experimental models based on species, strain, and method of seizure induction. Furthermore, removing the main source of t
Externí odkaz:
https://doaj.org/article/8b0559520bac4cc4a3dd7b9d43c236b9
Autor:
Robbie J. Ingram, Leanna K. Leverton, Victoria C. Daniels, Jiang Li, Catherine A. Christian-Hinman
Publikováno v:
Neurobiology of Disease, Vol 172, Iss , Pp 105822- (2022)
Patients with epilepsy develop reproductive endocrine comorbidities at a rate higher than that of the general population. Clinical studies have identified disrupted luteinizing hormone (LH) release patterns in patients of both sexes, suggesting poten
Externí odkaz:
https://doaj.org/article/1f2fcb5d2be14f81b491c0f571d5f8da
Autor:
Jennifer M. Walters, Eung Chang Kim, Jiaren Zhang, Han Gil Jeong, Archit Bajaj, Brian C. Baculis, Gregory C. Tracy, Baher Ibrahim, Catherine A. Christian‐Hinman, Daniel A. Llano, Graham R. Huesmann, Hee Jung Chung
Publikováno v:
Epilepsia. 63:1211-1224
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a brain-specific tyrosine phosphatase. Membrane-bound STEPAdult male and female C57BL/6J mice received intraperitoneal injection of either vehicle (2.8% dimethylsulfoxide [DMSO] in saline) or T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686bdcc6a69d139fcd9c1fb5e0c53047
https://doi.org/10.1111/epi.17192
https://doi.org/10.1111/epi.17192
Lateralization of hippocampal function is indicated by varied outcomes of patients with neurological disorders that selectively affect one hemisphere of this structure, such as temporal lobe epilepsy (TLE). The intrahippocampal kainic acid (IHKA) inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5672884ee646120231e0e80267c8e6f7
https://doi.org/10.1101/2023.01.20.524965
https://doi.org/10.1101/2023.01.20.524965
Autor:
Cathryn A. Cutia, Leanna K. Leverton, Karen E. Weis, Lori T. Raetzman, Catherine A. Christian-Hinman
Gonadotropin hormone release from the anterior pituitary is critical to regulating reproductive endocrine function. Clinical evidence has documented that people with epilepsy display altered levels of gonadotropin hormones, both acutely following sei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50dacd160cd0cabf4872070f8808f7ba
https://doi.org/10.1101/2022.11.16.516789
https://doi.org/10.1101/2022.11.16.516789
Autor:
Rajasekar Nagarajan, Jinrui Lyu, Maltesh Kambali, Muxiao Wang, Connor D. Courtney, Catherine A. Christian-Hinman, Uwe Rudolph
Aging is often associated with a decline in cognitive function. A reduction in the number of somatostatin-positive (SOM+) interneurons in the dentate gyrus (DG) has been described in cognitively impaired but not in unimpaired aged rodents. However, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4112842ae20fc403f55aee748f6535aa
https://doi.org/10.1101/2022.11.01.514756
https://doi.org/10.1101/2022.11.01.514756
Autor:
Cathryn A. Cutia, Leanna K. Leverton, Karen E. Weis, Lori T. Raetzman, Catherine A. Christian-Hinman
Publikováno v:
Experimental Neurology. 364:114389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ec8f7274f6d263cfc7e0506395ef3b
https://doi.org/10.1016/j.expneurol.2023.114389
https://doi.org/10.1016/j.expneurol.2023.114389
Publikováno v:
Epilepsy research. 184
Reproductive endocrine disorders are common comorbidities of temporal lobe epilepsy (TLE). Our previous studies using the intrahippocampal kainic acid (IHKA) mouse model of TLE demonstrated that many females show prolonged estrous cycles and hypothal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dade52e72f51e845773367cd853bde44
https://pubmed.ncbi.nlm.nih.gov/35690025
https://pubmed.ncbi.nlm.nih.gov/35690025
Autor:
Eung Chang Kim, Jiaren Zhang, Andy Y. Tang, Eric C. Bolton, Justin S. Rhodes, Catherine A. Christian-Hinman, Hee Jung Chung
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Epileptic encephalopathy (EE) is a devastating neurologic disorder characterized by early-onset seizures with severe cognitive and psychomotor impairments. EE is associated with dominant mutations in the KCNQ2 gene which encodes the K v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b84a63c25b3d3bf1e0870ba57d3a31d
https://doi.org/10.1073/pnas.2021265118
https://doi.org/10.1073/pnas.2021265118