Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Catherine A. Blizzard"'
Autor:
Rosemary M. Clark, Courtney M. Clark, Katherine E.A. Lewis, Marcus S. Dyer, Jyoti A. Chuckowree, Joshua A. Hoyle, Catherine A. Blizzard, Tracey C. Dickson
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 11, Pp 1985-1999 (2023)
Abstract Objective Neuropeptide Y (NPY) is a 36 amino acid peptide widely considered to provide neuroprotection in a range of neurodegenerative diseases. In the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), recent evidence supports
Externí odkaz:
https://doaj.org/article/246d624c3fe4468296d9e6f8d246f7ba
Autor:
Marcus S. Dyer, G. Lorenzo Odierna, Rosemary M. Clark, Adele Woodhouse, Catherine A. Blizzard
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Amyotrophic Lateral Sclerosis (ALS) is an incurable disease characterized by relentlessly progressive degeneration of the corticomotor system. Cortical hyperexcitability has been identified as an early pre-symptomatic biomarker of ALS. This suggests
Externí odkaz:
https://doaj.org/article/a373b867b43d4c239e7494e29d163436
Publikováno v:
Brain Sciences, Vol 11, Iss 7, p 883 (2021)
Amyotrophic lateral sclerosis (ALS) is defined by the destruction of upper- and lower motor neurons. Post-mortem, nearly all ALS cases are positive for cytoplasmic aggregates containing the DNA/RNA binding protein TDP-43. Recent studies indicate that
Externí odkaz:
https://doaj.org/article/dc5d963691b340b8840cbb46785264f2
Autor:
Tongcui Jiang, Emily Handley, Mariana Brizuela, Edgar Dawkins, Katherine E. A. Lewis, Rosemary M. Clark, Tracey C. Dickson, Catherine A. Blizzard
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 5 (2019)
Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization
Externí odkaz:
https://doaj.org/article/8a83b675ca364f0e947dde3eff0b5c6d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Cortical interneurons play a crucial role in regulating inhibitory-excitatory balance in brain circuits, filtering synaptic information and dictating the activity of pyramidal cells through the release of GABA. In the fatal motor neuron (MN) disease,
Externí odkaz:
https://doaj.org/article/ca502a7e74c5473fa48c435db04941fe
Autor:
Jyoti A. Chuckowree, Zhendan Zhu, Mariana Brizuela, Ka M. Lee, Catherine A. Blizzard, Tracey C. Dickson
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Microtubule dynamics underpin a plethora of roles involved in the intricate development, structure, function, and maintenance of the central nervous system. Within the injured brain, microtubules are vulnerable to misalignment and dissolution in neur
Externí odkaz:
https://doaj.org/article/1ac09fb2ab064fbda24c55a121f0ab6b
Autor:
Catherine A. Blizzard, Katherine A. Southam, Edgar Dawkins, Katherine E. Lewis, Anna E. King, Jayden A. Clark, Tracey C. Dickson
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 3, Pp 215-224 (2015)
There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compa
Externí odkaz:
https://doaj.org/article/f0fdcd3ed3b842c586a30e775dcb3170
Autor:
Emily E. Handley, Laura A. Reale, Jyoti A. Chuckowree, Marcus S. Dyer, Grace L. Barnett, Courtney M. Clark, William Bennett, Tracey C. Dickson, Catherine A. Blizzard
Publikováno v:
Molecular Neurobiology. 59:2962-2976
Amyotrophic lateral sclerosis (ALS) attacks the corticomotor system, with motor cortex function affected early in disease. Younger females have a lower relative risk of succumbing to ALS than males and older females, implicating a role for female sex
Autor:
Laura A. Reale, Marcus S. Dyer, Sharn E. Perry, Kaylene M. Young, Tracey C. Dickson, Adele Woodhouse, Catherine A. Blizzard
Publikováno v:
Progress in Neurobiology. 226:102449
Autor:
Laura A Reale, Marcus S Dyer, Tracey C. Dickson, Catherine A. Blizzard, Katherine E. Lewis, Adele Woodhouse, Adam K. Walker
Publikováno v:
Journal of Neurochemistry. 157:1300-1315
Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically characterised by mislocalisation of the RNA-binding protein TAR-DNA-binding protein 43 (TDP-43) from the nucleus to the cytoplasm. Changes to neuronal excitabil