Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis

Autor: Imre Noth, Yong Huang, Aliya N Husain, Shwu-Fan Ma, Jonathan Jou, Rob Guzy, Catherine A Bonham, Jefree J Schulte, John S Kim, Andrew J Barros, Milena S Espindola, Cory M Hogaboam, Anne I Sperling

Publikováno v: BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)

Rationale Contribution of central lung tissues to pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unknown.Objective To ascertain the relationship between cell types of IPF-central and IPF-peripheral lung explants using RNA sequencing (RNA

Externí odkaz: https://doaj.org/article/8ec06459ed0948489a762ccc76c5dcd7

COVID-19 patients exhibit unique transcriptional signatures indicative of disease severity

Autor: Andrea R. Daamen, Prathyusha Bachali, Catherine A. Bonham, Lindsay Somerville, Jeffrey M. Sturek, Amrie C. Grammer, Alexandra Kadl, Peter E. Lipsky

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

COVID-19 manifests a spectrum of respiratory symptoms, with the more severe often requiring hospitalization. To identify markers for disease progression, we analyzed longitudinal gene expression data from patients with confirmed SARS-CoV-2 infection

Externí odkaz: https://doaj.org/article/ae274b8bfc5f481298507a3548f53215

Idiopathic Pulmonary Fibrosis Genetic Risk Factors, Function, and Mechanisms? The Concepts Are Starting to Gel

Autor: Catherine A. Bonham, Imre Noth

Publikováno v: American journal of respiratory and critical care medicine. 206(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92395c974b9534f706fd629313772327
https://pubmed.ncbi.nlm.nih.gov/35816432

Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline

Autor: Marc A. Judson, Shandra L Knight, Wonder P. Drake, Marjolein Drent, Michael Ghobrial, Venerino Poletti, Ron Blankstein, Alicia K. Gerke, Daniel A. Culver, Laura L. Koth, W. Ennis James, Melissa H. Tukey, Elliott D. Crouser, Liz Kellermeyer, Subha V. Raman, Lisa A. Maier, Karen C. Patterson, Edward S. Chen, Eric Abston, Nabeel Hamzeh, Richard C. Bernstein, Adam S. Morgenthau, Catherine A. Bonham, Praveen Govender, Gloria Westney, Robert P. Baughman, Kevin C. Wilson

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 201(8), E26-E51. American Thoracic Society
Crouser, E D, Maier, L A, Baughman, R P, Abston, E, Bernstein, R C, Blankstein, R, Bonham, C A, Chen, E S, Culver, D A, Drake, W, Drent, M, Gerke, A K, Ghobrial, M, Govender, P, Hamzeh, N, James, W E, Judson, M A, Kellermeyer, L, Knight, S, Koth, L L, Morgenthau, A S, Patterson, K C, Poletti, V, Raman, S V, Tukey, M H, Westney, G E & Wilson, K C 2020, ' Diagnosis and Detection of Sarcoidosis An Official American Thoracic Society Clinical Practice Guideline ', American Journal of Respiratory and Critical Care Medicine, vol. 201, no. 8, pp. E26-E51 . https://doi.org/10.1164/RCCM.202002-0251ST
American Journal of Respiratory and Critical Care Medicine

Background: The diagnosis of sarcoidosis is not standardized but is based on three major criteria: a compatible clinical presentation, finding nonnecrotizing granulomatous inflammation in one or more tissue samples, and the exclusion of alternative c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaa629e60d0fab62aa8219a5b03bbab
https://doi.org/10.1164/rccm.202002-0251st

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

Autor: Monique Hinchcliff, Monica Chi, Manu Jain, Anna P. Lam, Vince K. Morgan, Gökhan M. Mutlu, Ali Shilatifard, Luís A. Nunes Amaral, A. Christine Argento, Satoshi Watanabe, Robert D. Guzy, SeungHye Han, Ankit Bharat, Colin T. Gillespie, Stacy A. Marshall, Kishore R. Anekalla, Ching I. Chen, Kiwon Nam, Alexandra C. McQuattie-Pimentel, Alexander V. Misharin, Remzi Bag, Annette S. Flozak, Harris Perlman, Karen M. Ridge, Rohan Verma, Benjamin D. Singer, James M. Walter, Jane Dematte, Catherine A. Bonham, Stephen Chiu, Ramiro Fernandez, Ziyou Ren, Cara L. Hrusch, Saul Soberanes, Anjana Yeldandi, Francisco J. Gonzalez-Gonzalez, Nikita Joshi, Hiam Abdala-Valencia, Trevor T. Nicholson, G. R. Scott Budinger, Sangeeta Bhorade, Anne I. Sperling, Paul A. Reyfman, Mahzad Akbarpour, Jacob I. Sznajder, Deborah R. Winter, Robert B. Hamanaka, Kinola J.N. Williams, Cara J. Gottardi

Publikováno v: American Journal of Respiratory and Critical Care Medicine

Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5b08bd503f998ca7b47f22338bd3f5
https://doi.org/10.1164/rccm.201712-2410oc