Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Catherine A, Doyle"'
Autor:
Catherine A. Doyle, Gregory W. Busey, Wesley H. Iobst, Volker Kiessling, Chloe Renken, Hansa Doppalapudi, Marta E. Stremska, Mohan C. Manjegowda, Mohd Arish, Weiming Wang, Shardul Naphade, Joel Kennedy, Louis-Marie Bloyet, Cassandra E. Thompson, Paul W. Rothlauf, Eric J. Stipes, Sean P. J. Whelan, Lukas K. Tamm, Alex J. B. Kreutzberger, Jie Sun, Bimal N. Desai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The majority of viruses classified as pandemic threats are enveloped viruses which enter the cell through receptor-mediated endocytosis and take advantage of endosomal acidification to activate their fusion machinery. Here we report that the
Externí odkaz:
https://doaj.org/article/dee6605d5bdc48a684b5ee4df122fe09
Autor:
Michael S. Schappe, Marta E. Stremska, Gregory W. Busey, Taylor K. Downs, Philip V. Seegren, Suresh K. Mendu, Zachary Flegal, Catherine A. Doyle, Eric J. Stipes, Bimal N. Desai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Efficient removal of apoptotic cells by phagocytosis underlies tissue development, wound repair, host defense and organ homeostasis. Here, authors identify TRPM7 as a regulator of cargo acidification and Ca2+ signaling during apoptotic cell clearance
Externí odkaz:
https://doaj.org/article/91b4d7f5e2564ec69283f69be2f00ae0
Autor:
Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that invo
Externí odkaz:
https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a21
Autor:
Louis C, Grandizio, Daniela F, Barreto Rocha, Daniel, Hayes, Eugene P, Warnick, Catherine M, Doyle, Michael, Suk, Joel C, Klena, Daniel S, Horwitz
Publikováno v:
Orthopedics. 46:121-127
Formal patient complaints and malpractice events involving orthopedic trauma surgeons (OTSs) can have substantial career implications. Our purpose was to analyze formal patient complaints, risk events, and malpractice events against OTSs during a 10-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef0d96fd2e0d416965191ffe6680b30
https://doi.org/10.3928/01477447-20221129-05
https://doi.org/10.3928/01477447-20221129-05
Autor:
George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249591 (2021)
Traumatic spinal cord injury (SCI) is a devastating neurological condition that involves both primary and secondary tissue loss. Various cytotoxic events including hypoxia, hemorrhage and blood lysis, bioenergetic failure, oxidative stress, endoplasm
Externí odkaz:
https://doaj.org/article/afcf059cd1dc42a1bcc67fbc7242ecef
Autor:
Alex J B Kreutzberger, Volker Kiessling, Catherine A Doyle, Noah Schenk, Clint M Upchurch, Margaret Elmer-Dixon, Amanda E Ward, Julia Preobraschenski, Syed S Hussein, Weronika Tomaka, Patrick Seelheim, Iman Kattan, Megan Harris, Binyong Liang, Anne K Kenworthy, Bimal N Desai, Norbert Leitinger, Arun Anantharam, J David Castle, Lukas K Tamm
Publikováno v:
eLife, Vol 9 (2020)
Insulin secretion from β-cells is reduced at the onset of type-1 and during type-2 diabetes. Although inflammation and metabolic dysfunction of β-cells elicit secretory defects associated with type-1 or type-2 diabetes, accompanying changes to insu
Externí odkaz:
https://doaj.org/article/6a3003b24de34ef2a6a794b8fb9446e1
Publikováno v:
Frontiers in Nutrition, Vol 5 (2018)
Introduction: Temozolomide (TMZ) is part of the standard of care for treating glioblastoma multiforme (GBM), an aggressive primary brain tumor. New approaches are needed to enhance therapeutic efficacy and reduce toxicity. GBM tumor cells are depende
Externí odkaz:
https://doaj.org/article/4f19abd584fc43c4b071f5bed5a352c1
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger
Publikováno v:
bioRxiv
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff3f156726e60f7df4ce4c7d4fff23
https://doi.org/10.1073/pnas.2210990119
https://doi.org/10.1073/pnas.2210990119
Autor:
Alex J.B. Kreutzberger, Anwesha Sanyal, Anand Saminathan, Louis-Marie Bloyet, Spencer Stumpf, Zhuoming Liu, Ravi Ojha, Markku T. Patjas, Ahmed Geneid, Gustavo Scanavachi, Catherine A. Doyle, Elliott Somerville, Ricardo Bango Da Cunha Correira, Giuseppe Di Caprio, Sanna Toppila-Salmi, Antti Mäkitie, Volker Kiessling, Olli Vapalahti, Sean P.J. Whelan, Giuseppe Balistreri, Tom Kirchhausen
Publikováno v:
bioRxiv
SARS-CoV-2 cell entry starts with membrane attachment and ends with spike-protein (S) catalyzed membrane fusion depending on two cleavage steps, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c73226a732a9a061ebcfb7498b6d56
https://doi.org/10.1073/pnas.2209514119
https://doi.org/10.1073/pnas.2209514119
Autor:
Matthew N. Mills, Timothy J. Robinson, Catherine M. Doyle, Julio C. Chavez, Sungjune Kim, G. Daniel Grass, G.Q. Yang, Young-Chul Kim, Daniel E. Oliver, Nicholas B Figura
Publikováno v:
Blood Cancer Journal, Vol 9, Iss 12, Pp 1-5 (2020)
Blood Cancer Journal
Blood Cancer Journal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ea1b6eda8101b2db0a4a8875489440
http://link.springer.com/article/10.1038/s41408-019-0269-6
http://link.springer.com/article/10.1038/s41408-019-0269-6