Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Catherine, Maclachlan"'
Autor:
Patrick A. Sandoz, Robin A. Denhardt-Eriksson, Laurence Abrami, Luciano A. Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Francisco S. Mesquita, Vassily Hatzimanikatis, F. Gisou van der Goot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by
Externí odkaz:
https://doaj.org/article/e2c0d4d357a547d2987d3099985f5053
Autor:
Jamshid Asadzadeh, Evelyne Ruchti, Wei Jiao, Greta Limoni, Catherine MacLachlan, Scott A. Small, Graham Knott, Ismael Santa-Maria, Brian D. McCabe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tau and the Retromer complex are both linked to Parkinson’s and Alzheimer’s disease. Using Drosophila neurodegeneration models, this study finds that low retromer activity induces a specific increase of a highly toxic truncated form of human Tau.
Externí odkaz:
https://doaj.org/article/1e7fd4b2b8cb486fa8804798fc3523c7
Autor:
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, François Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana V. Petrova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a “just-right” level and location of VEGFA signaling on
Externí odkaz:
https://doaj.org/article/4f38232a5b4a4d508652a6e98af1cc5f
Autor:
Anja C. Schlott, Ellen Knuepfer, Judith L. Green, Philip Hobson, Aaron J. Borg, Julia Morales-Sanfrutos, Abigail J. Perrin, Catherine Maclachlan, Lucy M. Collinson, Ambrosius P. Snijders, Edward W. Tate, Anthony A. Holder
Publikováno v:
PLoS Biology, Vol 19, Iss 10 (2021)
We have combined chemical biology and genetic modification approaches to investigate the importance of protein myristoylation in the human malaria parasite, Plasmodium falciparum. Parasite treatment during schizogony in the last 10 to 15 hours of the
Externí odkaz:
https://doaj.org/article/5fbf8e9a9f734a64b495f33819b59ac8
Autor:
Charles Van der Henst, Audrey Sophie Vanhove, Natália Carolina Drebes Dörr, Sandrine Stutzmann, Candice Stoudmann, Stéphanie Clerc, Tiziana Scrignari, Catherine Maclachlan, Graham Knott, Melanie Blokesch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The causative agent of cholera, Vibrio cholerae, is commonly found in aquatic habitats, where it must defend itself against predatory protists such as amoebae. Here, Van der Henst et al. analyze the molecular mechanisms by which V. cholerae thrives w
Externí odkaz:
https://doaj.org/article/203618c726ac4870be8c03f851a0bc89
Autor:
Federica Mangione, Joshua Titlow, Catherine Maclachlan, Michel Gho, Ilan Davis, Lucy Collinson, Nicolas Tapon
The epidermis is equipped with specialized mechanosensory organs that enable the detection of tactile stimuli. Here, by examining the differentiation of the tactile bristles, mechanosensory organs decorating the Drosophila adult epidermis, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e27a4af63bc5038b2f659307bfaaf3
Publikováno v:
Frontiers in Neuroanatomy, Vol 12 (2018)
In this article, we describe the method that allows fluorescently tagged structures such as axons to be targeted for electron microscopy (EM) analysis without the need to convert their labels into electron dense stains, introduce any fiducial marks,
Externí odkaz:
https://doaj.org/article/6d897e83a2a34cf0b83ca1e29c59cec7
Autor:
Minee L. Choi, Alexandre Chappard, Bhanu P. Singh, Catherine Maclachlan, Margarida Rodrigues, Evgenia Fedotova, Alexey V. Berezhnov, Suman De, Chris Peddie, Dilan Athauda, Gurvir S. Virdi, Weijia Zhang, James R. Evans, Anna Wernick, Zeinab Shadman Zanjani, Plamena R. Angelova, Noemi Esteras, Andrey Vinikurov, Katie Morris, Kiani Jeacock, Laura Tosatto, Daniel Little, Paul Gissen, David J. Clarke, Tilo Kunath, Lucy Collinson, David Klenerman, Andrey Y. Abramov, Mathew H. Horrocks, Sonia Gandhi
Aggregation of α-Synuclein (α-Syn) drives Parkinson’s disease, although the initial stages of self-assembly and structural conversion have not been captured inside neurons. We track the intracellular conformational states of α-Syn utilizing a si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5e925b510528dfd8626efac57f596d1
https://doi.org/10.1101/2022.06.07.494932
https://doi.org/10.1101/2022.06.07.494932
Autor:
Patrick Sandoz, Robin Denhardt-Eriksson, Laurence Abrami, Luciano Abriata, Gard Spreemann, Catherine Maclachlan, Sylvia Ho, Béatrice Kunz, Kathryn Hess, Graham Knott, Francisco Mesquita, Vassily Hatzimanikatis, F. van der Goot
The complex architecture of the endoplasmic reticulum (ER) comprises distinct dynamic features, many at the nanoscale, that enable the coexistence of the nuclear envelope, regions of dense sheets and a branched tubular network that spans the cytoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee5a4253516c7703b085e3f8c5cb7ac4
https://doi.org/10.21203/rs.3.rs-1373493/v1
https://doi.org/10.21203/rs.3.rs-1373493/v1
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Spiroplasma bacteria are highly motile bacteria with no cell wall and a helical morphology. This clade includes many vertically transmitted insect endosymbionts, including Spiroplasma poulsonii, a natural endosymbiont of Drosophila melanogas
Externí odkaz:
https://doaj.org/article/18befbe0cb9c441998ef0e1c9e52870b