Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Catherine, Godson"'
Autor:
Marisa Cañadas-Garre, Blanca Baños-Jaime, Joaquín J. Maqueda, Laura J. Smyth, Ruaidhri Cappa, Ryan Skelly, Claire Hill, Eoin P. Brennan, Ross Doyle, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Background Chronic kidney disease (CKD) is a complex disorder that has become a high prevalence global health problem, with diabetes being its predominant pathophysiologic driver. Autosomal genetic variation only explains some of the predisp
Externí odkaz:
https://doaj.org/article/99d65bf485c945c2820dafe74e4345b0
Autor:
Marisa Cañadas-Garre, Joaquín J. Maqueda, Blanca Baños-Jaime, Claire Hill, Ryan Skelly, Ruaidhri Cappa, Eoin Brennan, Ross Doyle, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionCardiovascular disease (CVD) is responsible for over 30% of mortality worldwide. CVD arises from the complex influence of molecular, clinical, social, and environmental factors. Despite the growing number of autosomal genetic variants con
Externí odkaz:
https://doaj.org/article/fd396bb37ab24ba998e03f620c3cd9f9
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Autor:
Marisa Cañadas-Garre, Andrew T. Kunzmann, Kerry Anderson, Eoin P. Brennan, Ross Doyle, Christopher C. Patterson, Catherine Godson, Alexander P. Maxwell, Amy Jayne McKnight
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11209 (2023)
Increased albuminuria indicates underlying glomerular pathology and is associated with worse renal disease outcomes, especially in diabetic kidney disease. Many single nucleotide polymorphisms (SNPs), associated with albuminuria, could be potentially
Externí odkaz:
https://doaj.org/article/9c9d3867893349169657a96a25039a43
Autor:
William P. Martin, Yeong H. D. Chuah, Mahmoud Abdelaal, Anders Pedersen, Daniel Malmodin, Sanna Abrahamsson, Michaela Hutter, Catherine Godson, Eoin P. Brennan, Lars Fändriks, Carel W. le Roux, Neil G. Docherty
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
BackgroundRoux-en-Y gastric bypass surgery (RYGB) improves biochemical and histological parameters of diabetic kidney disease (DKD). Targeted adjunct medical therapy may enhance renoprotection following RYGB.MethodsThe effects of RYGB and RYGB plus f
Externí odkaz:
https://doaj.org/article/374ee5c6e6134cd7a9d1691b372b6fab
Autor:
Silvia Oggero, Monica deGaetano, Simone Marcone, Stephen Fitzsimons, Andreia L. Pinto, Dinara Ikramova, Mary Barry, David Burke, Trinidad Montero‐Melendez, Dianne Cooper, Thomas Burgoyne, Orina Belton, Lucy V. Norling, Eoin P. Brennan, Catherine Godson, Mauro Perretti
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 6, Pp n/a-n/a (2021)
Abstract Extracellular vesicles (EVs) are emerging as key players in different stages of atherosclerosis. Here we provide evidence that EVs released by mixed aggregates of monocytes and platelets in response to TNF‐α display pro‐inflammatory act
Externí odkaz:
https://doaj.org/article/e2e22bed7e5c4e41a80f8c691c19795d
Publikováno v:
Annual Review of Pharmacology and Toxicology. 63:429-448
Inflammation and its timely resolution are critical to ensure effective host defense and appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation typifies many prevalent pathologies. The key mediators that initiate an
Autor:
McKnight, Marisa Cañadas-Garre, Andrew T. Kunzmann, Kerry Anderson, Eoin P. Brennan, Ross Doyle, Christopher C. Patterson, Catherine Godson, Alexander P. Maxwell, Amy Jayne
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11209
Increased albuminuria indicates underlying glomerular pathology and is associated with worse renal disease outcomes, especially in diabetic kidney disease. Many single nucleotide polymorphisms (SNPs), associated with albuminuria, could be potentially
Autor:
Carel W le Roux, Neil G Docherty, Lars Fändriks, Meera Nair, William P Martin, Vadim Zhernovkov, Naomi Fearon, Hans Eckhardt, Janet McCormack, Catherine Godson, Eoin Patrick Brennan
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction Roux-en-Y gastric bypass surgery (RYGB) reduces albuminuria and the long-term incidence of end-stage renal disease in patients with obesity and diabetes. Preclinical modeling in experimental diabetic kidney disease demonstrates that impr
Externí odkaz:
https://doaj.org/article/77cfb63081b94a10ba87892cd973b091
Publikováno v:
Organic Letters. 24:6049-6053