A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

Autor: Jason A. Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F. Choy, Alexis J. Combes, Tristan Courau, Gabriela K. Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F. Kuhn, Matthew F. Krummel, David J. Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S. Calfee, Prescott G. Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M. Hendrickson, Monique G.P. van der Wijst, George C. Hartoularos, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M. McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O. Rosas, Aviv Regev, Sharookh B. Kapadia, Rebecca N. Bauer, Carrie M. Rosenberger, Yumiko Abe-Jones, Michael Adkisson, K. Mark Ansel, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Cathy Cai, Saharai Caldera, Maria Calvo, Sidney A. Carrillo, Suzanna Chak, Stephanie Christenson, Zachary Collins, Spyros Darmanis, Angela Detweiler, Catherine DeVoe, Walter Eckalbar, Jeremy Giberson, Ana Gonzalez, Gracie Gordon, Paula Hayakawa Serpa, Alejandra Jauregui, Chayse Jones, Serena Ke, Divya Kushnoor, Tasha Lea, Deanna Lee, Aleksandra Leligdowicz, Yale Liu, Salman Mahboob, Lenka Maliskova, Michael Matthay, Elizabeth McCarthy, Priscila Muñoz-Sandoval, Norma Neff, Viet Nguyen, Nishita Nigam, Randy Parada, Maira Phelps, Logan Pierce, Priya Prasad, Sadeed Rashid, Gabriella Reeder, Nicklaus Rodriguez, Bushra Samad, Andrew Schroeder, Cole Shaw, Alan Shen, Austin Sigman, Pratik Sinha, Matthew Spitzer, Sara Sunshine, Kevin Tang, Luz Torres Altamirano, Alexandra Tsitsiklis, Erden Tumurbaatar, Vaibhav Upadhyay, Alexander Whatley, Andrew Willmore, Michael Wilson, Juliane Winkler, Kristine Wong, Kimberly Yee, Michelle Yu, Mingyue Zhou, Wandi S. Zhu

Publikováno v: iScience, Vol 26, Iss 10, Pp 107813- (2023)

Summary: Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across

Externí odkaz: https://doaj.org/article/9fcf76e7c2d9439cbd17b0a0b7fa8d89

Real-Life Use of Ceftolozane/Tazobactam for the Treatment of Bloodstream Infection Due to Pseudomonas aeruginosa in Neutropenic Hematologic Patients: a Matched Control Study (ZENITH Study)

Autor: Alba Bergas, Adaia Albasanz-Puig, Ana Fernández-Cruz, Marina Machado, Andrés Novo, David van Duin, Carolina Garcia-Vidal, Morgan Hakki, Isabel Ruiz-Camps, José Luis del Pozo, Chiara Oltolini, Catherine DeVoe, Lubos Drgona, Oriol Gasch, Malgorzata Mikulska, Pilar Martín-Dávila, Maddalena Peghin, Lourdes Vázquez, Júlia Laporte-Amargós, Xavier Durà-Miralles, Natàlia Pallarès, Eva González-Barca, Ana Álvarez-Uría, Pedro Puerta-Alcalde, Juan Aguilar-Company, Francisco Carmona-Torre, Teresa Daniela Clerici, Sarah B. Doernberg, Lucía Petrikova, Silvia Capilla, Laura Magnasco, Jesús Fortún, Nadia Castaldo, Jordi Carratalà, Carlota Gudiol

Publikováno v: Microbiology Spectrum, Vol 10, Iss 3 (2022)

ABSTRACT We sought to assess the characteristics and outcomes of neutropenic hematologic patients with Pseudomonas aeruginosa (PA) bloodstream infection (BSI) treated with ceftolozane-tazobactam (C/T). We conducted a multicenter, international, match

Externí odkaz: https://doaj.org/article/17326f4b85844a63bc6eb78401efa68c

Maribavir for Cytomegalovirus Treatment in the Real World—Not a Silver Bullet

Autor: Monica Fung, Catherine DeVoe, Natasha Spottiswoode, Sarah B Doernberg

Publikováno v: Open Forum Infectious Diseases. 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6d75da265fa404eb87c4af62f1f9018
https://doi.org/10.1093/ofid/ofac686

Increased rates of secondary bacterial infections, including Enterococcus bacteremia, in patients hospitalized with coronavirus disease 2019 (COVID-19)

Autor: Kim Stanley, Amy Nichols, Renee Graham-Ojo, Lusha Wang, Catherine DeVoe, Rajani Ghale, Sharline Madera, Joe Fan, Priya A. Prasad, Sarah L. Patterson, Kirsten N. Kangelaris, Deborah S. Yokoe, Yumiko Abe-Jones, Jonathan Schouest, Mark R. Segal, Christina Love, Charles Langelier

Publikováno v: Infection Control and Hospital Epidemiology
Infection control and hospital epidemiology, vol 43, iss 10

Objective:We compared the rates of hospital-onset secondary bacterial infections in patients with coronavirus disease 2019 (COVID-19) with rates in patients with influenza and controls, and we investigated reports of increased incidence of Enterococc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6114e5e41ad3d09687f2d791853e3788
https://doi.org/10.1017/ice.2021.391

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS

Autor: Eran Mick, Catherine DeVoe, Marina Sirota, Pratik Sinha, David J. Erle, Norma Neff, Michelle Tan, Alejandra Jauregui, Thomas Deiss, Paula Hayakawa Serpa, Angela Oliveira Pisco, Charles Langelier, Carolyn S. Calfee, Joseph L. DeRisi, Aleksandra Leligdowicz, Emily R. Siegel, Andrew Willmore, Matthew F. Krummel, Kirsten N. Kangelaris, Beth S. Zha, Alexandra Tsitsiklis, Jennifer G. Wilson, Rajani Ghale, Angela M Detweiler, Carolyn M. Hendrickson, Ashley Byrne, K. Mark Ansel, Farzad Moazed, Michael A. Matthay, Prescott G. Woodruff, Natasha Spottiswoode, Aartik Sarma, Stephanie A. Christenson

Publikováno v: Nature Communications
Nature communications, vol 12, iss 1
Research Square
article-version (status) pre
article-version (number) 1
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results of comparative lower respiratory tract transcriptional profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dde5802b2a31824671bee1141a4210
http://europepmc.org/articles/PMC8390461