Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Catherine, Chu"'
Autor:
Bing-Ze Yang, Mei-Yin Liu, Kuan-Lin Chiu, Yuh-Ling Chien, Ching-An Cheng, Yu-Lin Chen, Li-Yu Tsui, Keng-Ru Lin, Hsueh-Ping Catherine Chu, Ching-Shyi Peter Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract RNA helicase DHX9 is essential for genome stability by resolving aberrant R-loops. However, its regulatory mechanisms remain unclear. Here we show that SUMOylation at lysine 120 (K120) is crucial for DHX9 function. Preventing SUMOylation at
Externí odkaz:
https://doaj.org/article/d20bd17269914d3baa35b3b2dd79b01d
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Chromatin organization and dynamics play important roles in governing the regulation of nuclear processes of biological cells. However, due to the constant diffusive motion of chromatin, examining chromatin nanostructures in living cells has
Externí odkaz:
https://doaj.org/article/4229172f8ec846338651783bd34cfa36
Autor:
Alexi Vasbinder, Tonimarie Catalan, Elizabeth Anderson, Catherine Chu, Megan Kotzin, Danielle Murphy, Halle Cheplowitz, Kristen Machado Diaz, Brayden Bitterman, Ian Pizzo, Yiyuan Huang, Jeffrey Xie, Christopher W. Hoeger, Rayan Kaakati, Hanna P. Berlin, Husam Shadid, Daniel Perry, Michael Pan, Radhika Takiar, Kishan Padalia, Jamie Mills, Chelsea Meloche, Alina Bardwell, Matthew Rochlen, Pennelope Blakely, Monika Leja, Mousumi Banerjee, Mary Riwes, John Magenau, Sarah Anand, Monalisa Ghosh, Attaphol Pawarode, Gregory Yanik, Sunita Nathan, John Maciejewski, Tochukwu Okwuosa, Salim S. Hayek
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 1 (2024)
Background Evidence guiding the pre‐hematopoietic stem cell transplantation (HSCT) cardiovascular evaluation is limited. We sought to derive and validate a pre‐HSCT score for the cardiovascular risk stratification of HSCT candidates. Methods and
Externí odkaz:
https://doaj.org/article/13271a62a2f74e60a59b17357cea8380
Autor:
Chia-Yu Guh, Hong-Jhih Shen, Liv WeiChien Chen, Pei-Chen Chiu, I-Hsin Liao, Chen-Chia Lo, Yunfei Chen, Yu-Hung Hsieh, Ting-Chia Chang, Chien-Ping Yen, Yi-Yun Chen, Tom Wei-Wu Chen, Liuh-Yow Chen, Ching-Shyi Wu, Jean-Marc Egly, Hsueh-Ping Catherine Chu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend
Externí odkaz:
https://doaj.org/article/a1fb0e9f73254a64ac93c3ea84dcbcc8
Publikováno v:
European Journal of Case Reports in Internal Medicine (2023)
In light chain amyloidosis, a reduction in dFLC to below 40 mg/l is a prerequisite for organ recovery as nearly half of the patients who achieve very good partial haematological responses have improvement in the function of the involved organ. We des
Externí odkaz:
https://doaj.org/article/3f35036b5776433dade7c62df9dfcf21
Autor:
Weilai Dong, Karen H.Y. Wong, Youbin Liu, Michal Levy-Sakin, Wei-Chien Hung, Mo Li, Boyang Li, Sheng Chih Jin, Jungmin Choi, Francesc Lopez-Giraldez, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Irina Movsesyan, Mary J. Malloy, Hongyu Zhao, Pui-Yan Kwok, John P. Kane, Richard P. Lifton, Clive R. Pullinger
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 6, Pp 100209- (2022)
Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this research discovery study, we used whole-exome sequencing to iden
Externí odkaz:
https://doaj.org/article/9009d5614d1843c1a294988f08875cf9
Autor:
Karen H. Y. Wong, Walfred Ma, Chun-Yu Wei, Erh-Chan Yeh, Wan-Jia Lin, Elin H. F. Wang, Jen-Ping Su, Feng-Jen Hsieh, Hsiao-Jung Kao, Hsiao-Huei Chen, Stephen K. Chow, Eleanor Young, Catherine Chu, Annie Poon, Chi-Fan Yang, Dar-Shong Lin, Yu-Feng Hu, Jer-Yuarn Wu, Ni-Chung Lee, Wuh-Liang Hwu, Dario Boffelli, David Martin, Ming Xiao, Pui-Yan Kwok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The human reference genome does not fully reflect human genetic diversity. Here, the authors analyse 338 human genome assemblies from diverse populations to identify missing sequences, define non-reference unique insertions and construct a Human Dive
Externí odkaz:
https://doaj.org/article/c8c00ea643e14a5fb06226803d1d0cb0
Autor:
Michal Levy-Sakin, Steven Pastor, Yulia Mostovoy, Le Li, Alden K. Y. Leung, Jennifer McCaffrey, Eleanor Young, Ernest T. Lam, Alex R. Hastie, Karen H. Y. Wong, Claire Y. L. Chung, Walfred Ma, Justin Sibert, Ramakrishnan Rajagopalan, Nana Jin, Eugene Y. C. Chow, Catherine Chu, Annie Poon, Chin Lin, Ahmed Naguib, Wei-Ping Wang, Han Cao, Ting-Fung Chan, Kevin Y. Yip, Ming Xiao, Pui-Yan Kwok
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Large structural variants (SV) are understudied in human genetics research because of the difficulty to detect them in the routinely generated short-read sequencing data. Here, the authors generate optical genome maps of 154 individuals from 26 popul
Externí odkaz:
https://doaj.org/article/91ad69cc6ebb4dd28ba0a08624df46fd
Publikováno v:
Korean Journal of Orthodontics. 53:67-76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed34a7adf6340141c4bb2debb436932b
https://doi.org/10.4041/kjod22.076
https://doi.org/10.4041/kjod22.076
Autor:
Karen H.Y. Wong, Michal Levy‐Sakin, Walfred Ma, Nina Gonzaludo, Angel C.Y. Mak, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Zoe Grenville, Nicolas Wong, John P. Kane, Pui‐Yan Kwok, Mary J. Malloy, Clive R. Pullinger
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 12, Pp n/a-n/a (2019)
Abstract Background Homozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low‐density lipoprotein (LDL) cholesterol in affected individuals. It is usually caused by homozygous o
Externí odkaz:
https://doaj.org/article/d6dd132b586144a49db854b61fbb6e01