Symmetrical and Unsymmetrical Dicopper Complexes Based on Bis-Oxazoline Units: Synthesis, Spectroscopic Properties and Reactivity

Autor: James A. Isaac, Gisèle Gellon, Florian Molton, Christian Philouze, Nicolas Le Poul, Catherine Belle, Aurore Thibon-Pourret

Publikováno v: Inorganics, Vol 11, Iss 8, p 332 (2023)

Copper–oxygen adducts are known for being key active species for the oxidation of C–H bonds in copper enzymes and their synthetic models. In this work, the synthesis and spectroscopic characterizations of such intermediates using dinucleating lig

Externí odkaz: https://doaj.org/article/820753359b8043ca9bcf184e6f2b89d3

Exploiting HOPNO-dicopper center interaction to development of inhibitors for human tyrosinase

Autor: Elina Buitrago, Clarisse Faure, Marcello Carotti, Elisabetta Bergantino, Renaud Hardré, Marc Maresca, Christian Philouze, Nicolas Vanthuyne, Ahcène Boumendjel, Luigi Bubacco, Amaury du Moulinet d’Hardemare, Hélène Jamet, Marius Réglier, Catherine Belle

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2023, 248, pp.115090. ⟨10.1016/j.ejmech.2023.115090⟩

International audience; In human, Tyrosinase enzyme (TyH) is involved in the key steps of protective pigments biosynthesis (in skin, eyes and hair). The use of molecules targeting its binuclear copper active site represents a relevant strategy to reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf34e56eccee78d6f218516e3cf4b55
https://doi.org/10.1016/j.ejmech.2023.115090

Phase I/II investigator-initiated study of olaparib and temozolomide in SCLC: Updated analysis and CNS outcomes

Autor: Catherine Belle Meador, Subba Digumarthy, Beow Y. Yeap, Anna F. Farago, Rebecca Suk Heist, J Paul Marcoux, Deepa Rangachari, David Allen Barbie, Zofia Piotrowska

Publikováno v: Journal of Clinical Oncology. 40:8565-8565

8565 Background: Temozolomide has activity in small-cell lung cancer (SCLC), including patients (pts) with brain metastases (mets; Pietanza M, Clin Cancer Res 2012). Inhibition of Poly (ADP-ribose) polymerase (PARP) is another therapeutic strategy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4958862ff956d2ae537b71fdf5412963
https://doi.org/10.1200/jco.2022.40.16_suppl.8565

Exploring Coumarins Reduction: NaBH 4 /MeOH versus Nickel Boride Generated In Situ

Autor: Catherine Belle, Amaury du Moulinet d'Hardemare, Clarisse Faure, Hélène Jamet

Publikováno v: ChemistrySelect
ChemistrySelect, Wiley, 2020, 5 (46), pp.14735-14740. ⟨10.1002/slct.202004038⟩

International audience; The role of reagents NaBH4/MeOH and nickel boride (Ni2B)generated in situ from NaBH4 and NiCl2, are compared in thereduction process of coumarin and a variety of 3,7-substitutedcoumarins bearing electro-donating (ED-group) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78b32e3885f1e26064b836332860e6d
https://hal.univ-grenoble-alpes.fr/hal-03260569

High-valence CuIICuIII species in action: demonstration of aliphatic C–H bond activation at room temperature

Autor: Christian Philouze, Amélie Durand, Aurore Thibon-Pourret, Nicolas Le Poul, Catherine Belle, James A. Isaac

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2019, 55 (84), pp.12711-12714. ⟨10.1039/C9CC04422A⟩
Chemical Communications, Royal Society of Chemistry, 2019, 55 (84), pp.12711-12714. ⟨10.1039/c9cc04422a⟩

International audience; The electrochemically generated CuIICuIII mixed-valence species promotes activation of strong aliphatic C–H bonds (i.e. toluene) at room temperature. The mechanistic pathway turns from stoichiometric to catalytic upon additi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e168751ded1675cc2962ae034e7ffdf0
https://doi.org/10.1039/c9cc04422a