Výsledky vyhledávání - "Catherina Scharager-Tapia"

RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease

Autor: Qin Li, Supriya Swarnkar, Marie-Laure Thiolat, Tommaso Nuzzo, George Tsaprailis, Gogce Crynen, Nicole Galli, Catherina Scharager-Tapia, Mehdi Eshraghi, Arianna De Rosa, Erwan Bezard, Neelam Shahani, Srinivasa Subramaniam, Uri Nimrod Ramírez-Jarquín, Alessandro Usiello, Oscar Rivera

Publikováno v: Science Advances

A novel molecular target that signals abnormal involuntary movement in Parkinson’s disease treatment is discovered.
The therapeutic effects of l-3,4-dihydroxyphenylalanine (l-DOPA) in patients with Parkinson’s disease (PD) severely diminishe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b7d25157fe2b87e97367ca3894ab1d
http://hdl.handle.net/11591/436794

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RasGRP1 (CalDAG-GEF-II) Mediates L-DOPA-induced Dyskinesia in a Mouse Model of Parkinson Disease

Autor: Mehdi Ishragi, Catherina Scharager-Tapia, Srinivasa Subramaniam, George Tsaprailis, Alessandro Usiello, Neelam Shahani, Oscar Rivera, Gogce Crynen, Uri Nimrod Ramirez Jarquin, Supriya Swarnkar, Nicole Galli

The therapeutic benefits of L–3,4–dihydroxyphenylalanine (L-DOPA) in Parkinson disease (PD) patients diminishes with the onset of abnormal involuntary movements (L-DOPA induced dyskinesia), a debilitating motor side effect. L-DOPA induced dyskine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fe7853bd7170c351825e785ec7fc52
https://doi.org/10.1101/739631

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Software Analysis of Uncorrelated MS1 Peaks for Discovery of Post-Translational Modifications

Autor: Anthony C. Carvalloza, Bruce D. Pascal, Pablo Martínez-Acedo, Catherina Scharager-Tapia, Patrick R. Griffin, Ricardo Flefil, Graham M. West, Tina Moroni

Publikováno v: Journal of the American Society for Mass Spectrometry. 26:2133-2140

The goal in proteomics to identify all peptides in a complex mixture has been largely addressed using various LC MS/MS approaches, such as data dependent acquisition, SRM/MRM, and data independent acquisition instrumentation. Despite these developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e71798f1fac65c0dd2e4830731c2f6
https://doi.org/10.1007/s13361-015-1229-4

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RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ('Rhesactome') in the striatum

Autor: Srinivasa Subramaniam, Laura M. Bohn, Neelam Shahani, Kshitij Khare, Vincenzo Giovinazzo, Bruce D. Pascal, Pablo Martínez-Acedo, Supriya Swarnkar, Jenny Morgenweck, Catherina Scharager-Tapia

Publikováno v: Science Signaling. 9

The striatum of the brain coordinates motor function. Dopamine-related drugs may be therapeutic to patients with striatal neurodegeneration, such as Huntington’s disease (HD) and Parkinson’s disease (PD), but these drugs have unwanted side effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df76ba459dde8022893574e03c6ecb74
https://doi.org/10.1126/scisignal.aaf6670

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SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex

Autor: Bruce D. Pascal, Ruben D. Garcia-Ordonez, Graham M. West, Yelenis Mari, Catherina Scharager-Tapia, Patrick R. Griffin

Publikováno v: Journal of proteome research. 14(11)

Liver receptor homolog-1 (LRH1) is an orphan nuclear receptor that has been shown to play a role in the transcriptional regulation of pathways involved in cancer. Elucidating the components of the LRH1 transcriptional complex to better understand end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782b32e539b0217612286dc960ff27af
https://pubmed.ncbi.nlm.nih.gov/26398198

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