Recent discovery of natural substances with cathepsin L-inhibitory activity for cancer metastasis suppression.

Autor: Park JY; Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea., Park KM; Department of Food Science and Biotechnology, Wonkwang University, Iksan, 54538, Republic of Korea. Electronic address: kmpark79@wku.ac.kr.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Nov 05; Vol. 277, pp. 116754. Date of Electronic Publication: 2024 Aug 08.

The SPRi determination of cathepsin L and S in plasma and peritoneal fluid of women with endometriosis.

Autor: Załęcka J; Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Poland., Zielińska Z; Bioanalysis Laboratory, Doctoral School of Exact and Natural Science, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, Bialystok, Poland., Ołdak Ł; Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, Bialystok, Poland., Sakowicz A; Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland., Mańka G; Angelius Hospital, Katowice, Poland., Kiecka M; Angelius Hospital, Katowice, Poland., Spaczyński R; Center for Gynecology, Obstetrics and Infertility Treatment Pastelova, Poznan, Poland; Collegium Medicum, Institute of Health Sciences, University of Zielona Gora, Poland., Piekarski P; Gynecological Obstetric Clinical Hospital of Poznan University of Medical Sciences, Minimally Invasive Gynecological Surgery, Poznan, Poland., Banaszewska B; Chair and Department of Laboratory Diagnostics Poznan University of Medical Sciences, Poland., Jakimiuk A; Department of Reproductive Health, Institute of Mother and Child in Warsaw, Warsaw, Poland; Department of Gynecology, Oncological Gynecology and Reproduction, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland., Issat T; Department of Obstetrics and Gynecology, Institute of Mother and Child in Warsaw, Warsaw, Poland., Młodawski J; Collegium Medicum Jan Kochanowski University in Kielce, Poland; Clinic of Obstetrics and Gynecology, Provincial Combined Hospital in Kielce, Kielce, Poland., Szubert M; Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland; Department of Surgical Gynecology and Oncology, Medical University of Lodz, Lodz, Poland., Sieroszewski P; Department of Gynecology and Obstetrics, Medical University of Lodz, Lodz, Poland; Department of Fetal Medicine and Gynecology, Medical University of Lodz, Lodz, Poland., Raba G; Clinic of Obstetrics and Gynecology in Przemysl, Przemysl, Poland; Department of Obstetrics and Gynecology, University of Rzeszow, Rzeszow, Poland., Szczupak K; Clinic of Obstetrics and Gynecology in Przemysl, Przemysl, Poland; Department of Obstetrics and Gynecology, University of Rzeszow, Rzeszow, Poland., Kluz T; Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland., Kluza M; Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland., Pierzyński P; OVIklinika Infertility Center, Warsaw, Poland., Ciebiera M; Second Department of Obstetrics and Gynecology, Centre of Postrgraduate Medical Education, Warsaw, Poland; Warsaw Institute of Women's Health, Warsaw, Poland., Wojtyła C; OVIklinika Infertility Center, Warsaw, Poland; Women's Health Research Institute, Calisia University, Kalisz, Poland., Lipa M; Department of Obstetrics and Perinatology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland., Warzecha D; OVIklinika Infertility Center, Warsaw, Poland; City South Hospital Warsaw, Warsaw, Poland; Faculty of Medicine, University of Warsaw, Warsaw, Poland., Wielgoś M; Department of Obstetrics and Perinatology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland; Premium Medical Clinic, Warsaw, Poland; Medical Faculty, Lazarski University, Warsaw, Poland., Cendrowski K; Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Poland., Gorodkiewicz E; Bioanalysis Laboratory, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, Bialystok, Poland., Laudański P; Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, Poland; OVIklinika Infertility Center, Warsaw, Poland; Women's Health Research Institute, Calisia University, Kalisz, Poland. Electronic address: piotr.laudanski@wum.edu.pl.

Publikováno v: Advances in medical sciences [Adv Med Sci] 2024 Sep; Vol. 69 (2), pp. 224-230. Date of Electronic Publication: 2024 Apr 18.

Cytoskeletal β-tubulin and cysteine cathepsin L deregulation by SARS-CoV-2 spike protein interaction with the neuronal model cell line SH-SY5Y.

Autor: Oliveira BR; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany., Nehlmeier I; Deutsches Primatenzentrum - Leibniz-Institut für Primatenforschung, Abteilung Infektionsbiologie, Kellnerweg 4, D-37077, Göttingen, Germany. Electronic address: INehlmeier@dpz.eu., Kempf AM; Deutsches Primatenzentrum - Leibniz-Institut für Primatenforschung, Abteilung Infektionsbiologie, Kellnerweg 4, D-37077, Göttingen, Germany; Faculty of Biology and Psychology, Georg-August University Göttingen, Wilhelmsplatz 1, D-37073, Göttingen, Germany. Electronic address: AKempf@dpz.eu., Venugopalan V; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany., Rehders M; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany. Electronic address: mrehders@constructor.university., Ceniza MEP; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany. Electronic address: mceniza@constructor.university., Cavalcanti PATPV; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany. Electronic address: pcavalcanti@constructor.university., Hoffmann M; Deutsches Primatenzentrum - Leibniz-Institut für Primatenforschung, Abteilung Infektionsbiologie, Kellnerweg 4, D-37077, Göttingen, Germany; Faculty of Biology and Psychology, Georg-August University Göttingen, Wilhelmsplatz 1, D-37073, Göttingen, Germany. Electronic address: MHoffmann@dpz.eu., Pöhlmann S; Deutsches Primatenzentrum - Leibniz-Institut für Primatenforschung, Abteilung Infektionsbiologie, Kellnerweg 4, D-37077, Göttingen, Germany; Faculty of Biology and Psychology, Georg-August University Göttingen, Wilhelmsplatz 1, D-37073, Göttingen, Germany. Electronic address: SPoehlmann@dpz.eu., Brix K; Constructor University, School of Science, Campus Ring 1, D-28759, Bremen, Germany. Electronic address: kbrix@constructor.university.

Publikováno v: Biochimie [Biochimie] 2024 Nov; Vol. 226, pp. 49-61. Date of Electronic Publication: 2024 Mar 01.

Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L.

Autor: Deng W; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, KLMDASR of Tianjin and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300353, People's Republic of China., Hu X; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, KLMDASR of Tianjin and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300353, People's Republic of China., Tian X; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, KLMDASR of Tianjin and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300353, People's Republic of China., Zhang Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, KLMDASR of Tianjin and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300353, People's Republic of China., Shang W; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, People's Republic of China., Zhang L; Key Laboratory of Special Pathogens and Biosafety, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, People's Republic of China., Shang L; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, KLMDASR of Tianjin and Drug Discovery Center for Infectious Disease, Nankai University, Tianjin 300353, People's Republic of China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17124-17143. Date of Electronic Publication: 2024 Sep 18.

Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis.

Autor: Peng Z; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Department of Pharmacology, Xiangya School of Pharmaceutical Science (Z.P., Y.W., B.P., C.Q., Xiaohui Li), Central South University, Changsha, China., Luo XY; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital (XY. L, Xinyi Li, Y. T., A.F.C.), Shanghai Jiao Tong University School of Medicine, China., Li X; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital (XY. L, Xinyi Li, Y. T., A.F.C.), Shanghai Jiao Tong University School of Medicine, China., Li Y; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Health Management Medicine Center, the Third Xiangya Hospital (Yapei Li., Ying Li.), Central South University, Changsha, China., Wu Y; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Department of Pharmacology, Xiangya School of Pharmaceutical Science (Z.P., Y.W., B.P., C.Q., Xiaohui Li), Central South University, Changsha, China., Tian Y; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital (XY. L, Xinyi Li, Y. T., A.F.C.), Shanghai Jiao Tong University School of Medicine, China., Pan B; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Department of Pharmacology, Xiangya School of Pharmaceutical Science (Z.P., Y.W., B.P., C.Q., Xiaohui Li), Central South University, Changsha, China., Petrovic A; Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Germany (A.P., R.T.S., C.R., A.G.)., Kosanovic D; Department of Pulmonology, I.M. Sechenov First Moscow State Medical University, Russia (D.K.)., Schermuly RT; Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Germany (A.P., R.T.S., C.R., A.G.)., Ruppert C; Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Germany (A.P., R.T.S., C.R., A.G.)., Günther A; Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Germany (A.P., R.T.S., C.R., A.G.)., Zhang Z; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China., Qiu C; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Department of Pharmacology, Xiangya School of Pharmaceutical Science (Z.P., Y.W., B.P., C.Q., Xiaohui Li), Central South University, Changsha, China., Li Y; Health Management Medicine Center, the Third Xiangya Hospital (Yapei Li., Ying Li.), Central South University, Changsha, China., Pu J; Department of Cardiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital (J.P.), Shanghai Jiao Tong University School of Medicine, China., Li X; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Department of Pharmacology, Xiangya School of Pharmaceutical Science (Z.P., Y.W., B.P., C.Q., Xiaohui Li), Central South University, Changsha, China., Chen AF; The Center for Vascular Disease and Translational Medicine, the Third Xiangya Hospital (Z.P., Yapei Li., Y.W., B.P., Z.Z., C.Q., Xiaohui Li, A.F.C.), Central South University, Changsha, China.; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital (XY. L, Xinyi Li, Y. T., A.F.C.), Shanghai Jiao Tong University School of Medicine, China.

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Dec; Vol. 81 (12), pp. 2430-2443. Date of Electronic Publication: 2024 Oct 15.