Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Catharine M Bosio"'
Autor:
Anne Ward, Forrest Jessop, Robert Faris, Jason Hollister, Daniel Shoup, Brent Race, Catharine M Bosio, Suzette A Priola
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298095 (2024)
The PINK1/Parkin pathway of mitophagy has been implicated in the pathogenesis of Parkinson's disease. In prion diseases, a transmissible neurodegenerative disease caused by the misfolded and infectious prion protein (PrPSc), expression of both PINK1
Externí odkaz:
https://doaj.org/article/598e0040e30a4b93b9876823043878ef
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293450 (2023)
Route of exposure to pathogens can inform divergent disease pathogenesis and mortality rates. However, the features that contribute to these differences are not well established. Host metabolism has emerged as a critical element governing susceptibil
Externí odkaz:
https://doaj.org/article/bcab7d6c734043fa8b30d677f7743992
Autor:
Simote T Foliaki, Anna Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M Bosio, Katie Williams, Christina D Orrú, Hailey Lachenauer, Bradley R Groveman, Cathryn L Haigh
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010565 (2023)
Fatal familial insomnia (FFI) is a rare neurodegenerative disease caused by a dominantly inherited single amino acid substitution (D178N) within the prion protein (PrP). No in vitro human brain tissue model for this disease has previously been availa
Externí odkaz:
https://doaj.org/article/5f44df8f953e4e0d8120b3a7928318d2
Autor:
Dan Drecktrah, Laura S Hall, Bethany Crouse, Benjamin Schwarz, Crystal Richards, Eric Bohrnsen, Michael Wulf, Bonnie Long, Jessica Bailey, Frank Gherardini, Catharine M Bosio, Meghan C Lybecker, D Scott Samuels
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010385 (2022)
We have identified GpsA, a predicted glycerol-3-phosphate dehydrogenase, as a virulence factor in the Lyme disease spirochete Borrelia (Borreliella) burgdorferi: GpsA is essential for murine infection and crucial for persistence of the spirochete in
Externí odkaz:
https://doaj.org/article/47aa20de68904d7fa81e1d4307afbf65
Autor:
Anne Ward, Forrest Jessop, Robert Faris, Daniel Shoup, Catharine M Bosio, Karin E Peterson, Suzette A Priola
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267720 (2022)
Prion diseases are a group of fatal, transmissible neurodegenerative diseases of mammals. In the brain, axonal loss and neuronal death are prominent in prion infection, but the mechanisms remain poorly understood. Sterile alpha and heat/Armadillo mot
Externí odkaz:
https://doaj.org/article/df82522c225a46529beed09fa86956c3
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82096 (2013)
Virulent Francisella tularensis ssp tularensis is an intracellular, Gram negative bacterium that causes acute lethal disease following inhalation of fewer than 15 organisms. Pathogenicity of Francisella infections is tied to its unique ability to eva
Externí odkaz:
https://doaj.org/article/240a6df3c82d472697796ca7109b6c65
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33349 (2012)
Francisella tularensis is a facultative intracellular bacterium and the causative agent of tularemia. Development of novel vaccines and therapeutics for tularemia has been hampered by the lack of understanding of which immune components are required
Externí odkaz:
https://doaj.org/article/1553e321cd88411db626d4f2b11ff2cd
Autor:
Roberto De Pascalis, Alicia Y Chou, Catharine M Bosio, Chiung-Yu Huang, Dean A Follmann, Karen L Elkins
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002494 (2012)
In contrast with common human infections for which vaccine efficacy can be evaluated directly in field studies, alternative strategies are needed to evaluate efficacy for slowly developing or sporadic diseases like tularemia. For diseases such as the
Externí odkaz:
https://doaj.org/article/8ec97ec5a78249b8855c2bfbca479214
Autor:
Dedeke Rockx-Brouwer, Audrey Chong, Tara D Wehrly, Robert Child, Deborah D Crane, Jean Celli, Catharine M Bosio
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37752 (2012)
Tularemia, caused by the gram-negative bacterium Francisella tularensis, is a severe, sometimes fatal disease. Interest in tularemia has increased over the last decade due to its history as a biological weapon. In particular, development of novel vac
Externí odkaz:
https://doaj.org/article/354bf3ef51e0422b8362ef4ce631232c
Autor:
Robin Ireland, Norma Olivares-Zavaleta, Jonathan M Warawa, Frank C Gherardini, Clayton Jarrett, B Joseph Hinnebusch, John T Belisle, Jeffery Fairman, Catharine M Bosio
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000921 (2010)
Protection against virulent pathogens that cause acute, fatal disease is often hampered by development of microbial resistance to traditional chemotherapeutics. Further, most successful pathogens possess an array of immune evasion strategies to avoid
Externí odkaz:
https://doaj.org/article/93aea17ff17e45c59cca2be8c7ad4968