Impulse Control Disorders in Parkinson’s Disease: From Bench to Bedside

Autor: Andrea Augustine, Catharine A. Winstanley, Vaishnav Krishnan

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include exces

Externí odkaz: https://doaj.org/article/9e3470fff7d64769832d6ff3e13d7571

Win-paired cues modulate the effect of dopamine neuron sensitization on decision making and cocaine self-administration: divergent effects across sex

Autor: Tristan J. Hynes, Chloe S. Chernoff, Kelly M. Hrelja, Maric T.L. Tse, Dimitrios Avramidis, Melanie R. Lysenko-Martin, Lucas Calderhead, Sukhbir Kaur, Stan B. Floresco, Catharine A. Winstanley

Psychostimulant use and engagement with probabilistic schedules of reward both sensitize the mesocorticolimbic dopamine system. Such behaviours may act synergistically to explain the high comorbidity between stimulant use and gambling disorder. The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39097b3f49f9583201941023b19842e4
https://doi.org/10.1101/2023.05.19.541413

Divergent effects of oral cannabis oil extracts marketed as C. indica or C. sativa on exertion of cognitive effort in rats

Autor: Hannah G. Brodie, Brett A. Hathaway, Andrew Li, Samantha L. Baglot, Sukhbir Kaur, Matthew N. Hill, Catharine A. Winstanley

Publikováno v: Behavioral neuroscience.

The main psychoactive compound within the cannabis plant, Δ9-tetrahydrocannabinol (THC), is thought to drive both the sensation of "high" and the cognitive impairments associated with cannabis consumption. Researchers keen to understand how cannabis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afb9cab31cbba5d54e617c14d56a52c
https://pubmed.ncbi.nlm.nih.gov/36395021

Neural Mechanisms Mediating Sex Differences in Motivation for Reward: Cognitive Bias, Food, Gambling, and Drugs of Abuse

Autor: Caitlin A. Orsini, Travis E. Brown, Travis E. Hodges, Yanaira Alonso-Caraballo, Catharine A. Winstanley, Jill B. Becker

Publikováno v: J Neurosci

Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues, drugs of abuse, and a high-fat diet can significantly impact neural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8897c628c349598945131352081ef4e1
https://pubmed.ncbi.nlm.nih.gov/36351834

Decreased risk‐taking and loss‐chasing after subthalamic nucleus lesion in rats

Autor: Emmanuel Breysse, Christelle Baunez, Catharine A. Winstanley, Julie Meffre, Yann Pelloux

Publikováno v: European Journal of Neuroscience
European Journal of Neuroscience, Wiley, 2020, 00, ⟨10.1111/ejn.14895⟩
European Journal of Neuroscience, 2020, 00, ⟨10.1111/ejn.14895⟩

International audience; The subthalamic nucleus (STN) is known to play a role in the control of impulsivity of action and in impulsivity of choice under certain conditions. In order to assess its influence on decision-making under uncertainty, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391811d5d5747ebac906470c7fe51781
https://doi.org/10.1111/ejn.14895