Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense

Autor: Eva Horáková, Laurence Lecordier, Paula Cunha, Roman Sobotka, Piya Changmai, Catharina J. M. Langedijk, Jan Van Den Abbeele, Benoit Vanhollebeke, Julius Lukeš

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Decreased functionality and expression of trypanosome haptoglobin-hemoglobin receptor (HpHbR) is one of the evolutionary modifications that have allowed Trypanosoma brucei gambiense to infect humans. Here, Horakova et al. show that hemoglobin uptake

Externí odkaz: https://doaj.org/article/d9d5e11313584e82a32aad5a820d21ac

Mucosal Dendritic Cell Subsets Control HIV-1's Viral Fitness

Autor: Teunis B. H. Geijtenbeek, Catharina J. M. Langedijk, Bernadien M. Nijmeijer

Publikováno v: Annual review of virology. 7(1)

Dendritic cell (DC) subsets are abundantly present in genital and intestinal mucosal tissue and are among the first innate immune cells that encounter human immunodeficiency virus type 1 (HIV-1) after sexual contact. Although DCs have specific charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc4cd631c4b55ca388030e5e004eead
https://pubmed.ncbi.nlm.nih.gov/32991263

Syndecan 4 Upregulation on Activated Langerhans Cells Counteracts Langerin Restriction to Facilitate Hepatitis C Virus Transmission

Autor: Carla M. S. Ribeiro, Bernadien M. Nijmeijer, Pascale Zimmermann, Julia Eder, Catharina J. M. Langedijk, Tanja M. Kaptein, Sofie Meeussen, Teunis B. H. Geijtenbeek

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2020, 11 (1), ⟨10.3389/fimmu.2020.00503⟩
Frontiers in Immunology, 2020, 11 (1), ⟨10.3389/fimmu.2020.00503⟩
Frontiers in Immunology, Vol 11 (2020)
Frontiers in immunology, 11:503. Frontiers Media S.A.

Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM. Immune activation and/or HIV-1 coinfection enhance HCV susceptibility vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e677168a719d6e81805168c1f198c4d
https://lirias.kuleuven.be/handle/123456789/654864