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of 4
pro vyhledávání: '"Catharina Combrinck"'
Autor:
Amy McCaughey-Chapman, Anne Lieke Burgers, Catharina Combrinck, Laura Marriott, David Gordon, Bronwen Connor
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Huntington’s disease (HD) is a genetic neurological disorder predominantly characterised by the progressive loss of GABAergic medium spiny neurons in the striatum resulting in motor dysfunction. One potential strategy for the tr
Externí odkaz:
https://doaj.org/article/53284fd4f2534acabd19ab512f31d9be
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionThe neurodevelopmental disorder fragile X syndrome (FXS) is the most common monogenic cause of intellectual disability associated with autism spectrum disorder. Inaccessibility to developing human brain cells is a major barrier to studyin
Externí odkaz:
https://doaj.org/article/fa816c69e196481ebf9c7a27d89ce9fe
Autor:
Amy McCaughey-Chapman, Marta Tarczyluk-Wells, Catharina Combrinck, Nicole Edwards, Kathryn Jones, Bronwen Connor
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Introduction: With the increase in aging populations around the world, the development of in vitro human cell models to study neurodegenerative disease is crucial. A major limitation in using induced pluripotent stem cell (hiPSC) technology to model
Externí odkaz:
https://doaj.org/article/2a72fea8ad2542df9d9a7d728671482b
Publikováno v:
Stem cells and development. 31(3-4)
The development of human cell-based platforms for disease modeling, drug discovery, and regenerative therapy relies on robust and practical methods to derive high yields of relevant neuronal subtypes. Direct reprogramming strategies have sought to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a99ffff4e70d6c29c9680d738c4e55e3
https://pubmed.ncbi.nlm.nih.gov/34963331
https://pubmed.ncbi.nlm.nih.gov/34963331